<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2023 Workiva-->
<!--r:8a3c349c-2543-4c58-aab3-1a46d28e7c33,g:b3ff8cf4-2b77-4318-b2a7-331d07a8003a-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.aadi.com/role/CondensedConsolidatedStatementsofOperations" xlink:type="simple" xlink:href="aadi-20230331.xsd#CondensedConsolidatedStatementsofOperations"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/CondensedConsolidatedStatementsofOperations" xlink:type="extended" id="i90be7a5b05564eed9ea7b6386c130441_CondensedConsolidatedStatementsofOperations">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_ec1aeba3-9810-4e2e-8c9c-8cf04e3d43f6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_a373a3bf-83bb-4c59-8775-bb4078acd0ec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_ec1aeba3-9810-4e2e-8c9c-8cf04e3d43f6" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_a373a3bf-83bb-4c59-8775-bb4078acd0ec" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpensesAbstract_2cf47003-64c9-49a6-be9d-ce3117fc7ec1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingExpensesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_ec1aeba3-9810-4e2e-8c9c-8cf04e3d43f6" xlink:to="loc_us-gaap_OperatingExpensesAbstract_2cf47003-64c9-49a6-be9d-ce3117fc7ec1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_536af49c-c1bc-418a-b726-8319b6f745f9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_2cf47003-64c9-49a6-be9d-ce3117fc7ec1" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_536af49c-c1bc-418a-b726-8319b6f745f9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_42aa234c-a6e0-4dff-b496-f45e62149b86" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_2cf47003-64c9-49a6-be9d-ce3117fc7ec1" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_42aa234c-a6e0-4dff-b496-f45e62149b86" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_2291a13a-30ac-4197-b0d2-b8ce22899321" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_2cf47003-64c9-49a6-be9d-ce3117fc7ec1" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_2291a13a-30ac-4197-b0d2-b8ce22899321" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_11d966c3-e9a2-4d58-aebd-45b20d0e3e87" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostsAndExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_2cf47003-64c9-49a6-be9d-ce3117fc7ec1" xlink:to="loc_us-gaap_CostsAndExpenses_11d966c3-e9a2-4d58-aebd-45b20d0e3e87" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_c573a44f-c091-4e95-baef-7a85de5967f0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_ec1aeba3-9810-4e2e-8c9c-8cf04e3d43f6" xlink:to="loc_us-gaap_OperatingIncomeLoss_c573a44f-c091-4e95-baef-7a85de5967f0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_16d1f741-045f-4389-be44-8773674ea746" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherNonoperatingIncomeExpenseAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_ec1aeba3-9810-4e2e-8c9c-8cf04e3d43f6" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_16d1f741-045f-4389-be44-8773674ea746" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_f027c05d-9790-4cce-a1d4-b4d14b9176ff" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_16d1f741-045f-4389-be44-8773674ea746" xlink:to="loc_us-gaap_InvestmentIncomeInterest_f027c05d-9790-4cce-a1d4-b4d14b9176ff" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_f82a18b8-b971-438a-9564-8b9510a35df8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_16d1f741-045f-4389-be44-8773674ea746" xlink:to="loc_us-gaap_InterestExpense_f82a18b8-b971-438a-9564-8b9510a35df8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_c7ed4875-3433-435c-a168-510702c0a523" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_16d1f741-045f-4389-be44-8773674ea746" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_c7ed4875-3433-435c-a168-510702c0a523" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_da926e84-d73f-472a-935f-7f8449037fd6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_ec1aeba3-9810-4e2e-8c9c-8cf04e3d43f6" xlink:to="loc_us-gaap_NetIncomeLoss_da926e84-d73f-472a-935f-7f8449037fd6" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_dd422d68-bc3c-4a8b-b4c3-4b55d9d228bc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_ec1aeba3-9810-4e2e-8c9c-8cf04e3d43f6" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_dd422d68-bc3c-4a8b-b4c3-4b55d9d228bc" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_331e93a7-d8aa-4003-b816-bfdcab089fbb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_dd422d68-bc3c-4a8b-b4c3-4b55d9d228bc" xlink:to="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_331e93a7-d8aa-4003-b816-bfdcab089fbb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_d03bbbce-e8fe-4239-9c71-319b6f30400d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_ec1aeba3-9810-4e2e-8c9c-8cf04e3d43f6" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTax_d03bbbce-e8fe-4239-9c71-319b6f30400d" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_787fb621-f186-4bbd-b20a-9e1fa5cb1adb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_ec1aeba3-9810-4e2e-8c9c-8cf04e3d43f6" xlink:to="loc_us-gaap_EarningsPerShareBasic_787fb621-f186-4bbd-b20a-9e1fa5cb1adb" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_bb7cbf19-1e93-41ef-937c-7b4ee7bbf88b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_ec1aeba3-9810-4e2e-8c9c-8cf04e3d43f6" xlink:to="loc_us-gaap_EarningsPerShareDiluted_bb7cbf19-1e93-41ef-937c-7b4ee7bbf88b" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_1c472616-ec3f-442a-88a9-70a591490121" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_ec1aeba3-9810-4e2e-8c9c-8cf04e3d43f6" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_1c472616-ec3f-442a-88a9-70a591490121" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_56d593ce-4a4e-4430-9702-69f60d3f6f3d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_ec1aeba3-9810-4e2e-8c9c-8cf04e3d43f6" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_56d593ce-4a4e-4430-9702-69f60d3f6f3d" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_9c84ae16-adc8-48a2-a9ab-b1b2065cdd00" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_ec1aeba3-9810-4e2e-8c9c-8cf04e3d43f6" xlink:to="loc_us-gaap_StatementTable_9c84ae16-adc8-48a2-a9ab-b1b2065cdd00" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_6406684d-74b6-436a-baf1-547e4eb984ba" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_9c84ae16-adc8-48a2-a9ab-b1b2065cdd00" xlink:to="loc_srt_ProductOrServiceAxis_6406684d-74b6-436a-baf1-547e4eb984ba" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_6406684d-74b6-436a-baf1-547e4eb984ba_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_6406684d-74b6-436a-baf1-547e4eb984ba" xlink:to="loc_srt_ProductsAndServicesDomain_6406684d-74b6-436a-baf1-547e4eb984ba_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_230907b7-aaf0-4a4b-a46f-d082bb2dd8cc" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_6406684d-74b6-436a-baf1-547e4eb984ba" xlink:to="loc_srt_ProductsAndServicesDomain_230907b7-aaf0-4a4b-a46f-d082bb2dd8cc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductMember_66cbfce8-38f0-4a7c-b35a-e863209fb2c7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProductMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_230907b7-aaf0-4a4b-a46f-d082bb2dd8cc" xlink:to="loc_us-gaap_ProductMember_66cbfce8-38f0-4a7c-b35a-e863209fb2c7" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.aadi.com/role/CondensedConsolidatedStatementsofStockholdersEquity" xlink:type="simple" xlink:href="aadi-20230331.xsd#CondensedConsolidatedStatementsofStockholdersEquity"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/CondensedConsolidatedStatementsofStockholdersEquity" xlink:type="extended" id="if42214b092b54bf09af47184e5e98a0e_CondensedConsolidatedStatementsofStockholdersEquity">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_05d9da12-dc97-4473-9a50-e7d52773ad14" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a0a20f4e-b0fd-4e67-898c-b382bacc4c70" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_05d9da12-dc97-4473-9a50-e7d52773ad14" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a0a20f4e-b0fd-4e67-898c-b382bacc4c70" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_63ee2f08-60f6-47e2-8cba-bc121af4eec5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a0a20f4e-b0fd-4e67-898c-b382bacc4c70" xlink:to="loc_us-gaap_SharesOutstanding_63ee2f08-60f6-47e2-8cba-bc121af4eec5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_419d8462-f2f7-477a-8bca-75f59d84d05b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a0a20f4e-b0fd-4e67-898c-b382bacc4c70" xlink:to="loc_us-gaap_StockholdersEquity_419d8462-f2f7-477a-8bca-75f59d84d05b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_c8336742-8204-4144-955d-63bea693ea06" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a0a20f4e-b0fd-4e67-898c-b382bacc4c70" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_c8336742-8204-4144-955d-63bea693ea06" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_StockIssuedDuringPeriodSharesWarrantExercised_8355e9a2-29df-40a9-90a7-15eb9f3d7fd9" xlink:href="aadi-20230331.xsd#aadi_StockIssuedDuringPeriodSharesWarrantExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a0a20f4e-b0fd-4e67-898c-b382bacc4c70" xlink:to="loc_aadi_StockIssuedDuringPeriodSharesWarrantExercised_8355e9a2-29df-40a9-90a7-15eb9f3d7fd9" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_StockIssuedDuringPeriodValueWarrantExercised_42f803cd-5dc5-4cb2-abd3-31f75ad98cc2" xlink:href="aadi-20230331.xsd#aadi_StockIssuedDuringPeriodValueWarrantExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a0a20f4e-b0fd-4e67-898c-b382bacc4c70" xlink:to="loc_aadi_StockIssuedDuringPeriodValueWarrantExercised_42f803cd-5dc5-4cb2-abd3-31f75ad98cc2" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_d0924338-0e3f-4589-861b-b7854dbef156" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a0a20f4e-b0fd-4e67-898c-b382bacc4c70" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_d0924338-0e3f-4589-861b-b7854dbef156" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_7593ef9e-6909-447d-babc-45270b8d42d5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a0a20f4e-b0fd-4e67-898c-b382bacc4c70" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_7593ef9e-6909-447d-babc-45270b8d42d5" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_2c911552-7f90-41c2-a553-d444d5ccf7af" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a0a20f4e-b0fd-4e67-898c-b382bacc4c70" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_2c911552-7f90-41c2-a553-d444d5ccf7af" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_1590149a-024a-4399-a577-16ee03b8413c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_a0a20f4e-b0fd-4e67-898c-b382bacc4c70" xlink:to="loc_us-gaap_NetIncomeLoss_1590149a-024a-4399-a577-16ee03b8413c" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_83d5239e-ae83-4440-b7c3-dffe3af2e3a6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_062ea25e-c080-4bd5-9938-fa04d079d1c3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_459615c6-0be6-4558-aa92-10fa03afe4aa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_05d9da12-dc97-4473-9a50-e7d52773ad14" xlink:to="loc_us-gaap_StatementTable_459615c6-0be6-4558-aa92-10fa03afe4aa" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_a0e38b04-de89-4a41-b5f7-16c6e062530e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_459615c6-0be6-4558-aa92-10fa03afe4aa" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_a0e38b04-de89-4a41-b5f7-16c6e062530e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_a0e38b04-de89-4a41-b5f7-16c6e062530e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_a0e38b04-de89-4a41-b5f7-16c6e062530e" xlink:to="loc_us-gaap_EquityComponentDomain_a0e38b04-de89-4a41-b5f7-16c6e062530e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_06caed2b-cfba-4975-9180-18025bd59bca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_a0e38b04-de89-4a41-b5f7-16c6e062530e" xlink:to="loc_us-gaap_EquityComponentDomain_06caed2b-cfba-4975-9180-18025bd59bca" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_2fe4e4f8-5142-4865-9f1a-7b40681db96a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_06caed2b-cfba-4975-9180-18025bd59bca" xlink:to="loc_us-gaap_CommonStockMember_2fe4e4f8-5142-4865-9f1a-7b40681db96a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_ede3f47b-7f37-4c19-b836-c271bb8c5c11" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_06caed2b-cfba-4975-9180-18025bd59bca" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_ede3f47b-7f37-4c19-b836-c271bb8c5c11" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_060608ea-ba7e-40cc-93da-0fe559a604ce" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_06caed2b-cfba-4975-9180-18025bd59bca" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_060608ea-ba7e-40cc-93da-0fe559a604ce" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_a2abb48c-6f2f-42ba-bf08-536bddbcb057" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_06caed2b-cfba-4975-9180-18025bd59bca" xlink:to="loc_us-gaap_RetainedEarningsMember_a2abb48c-6f2f-42ba-bf08-536bddbcb057" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.aadi.com/role/NatureofOrganizationandOperationsAdditionalInformationDetail" xlink:type="simple" xlink:href="aadi-20230331.xsd#NatureofOrganizationandOperationsAdditionalInformationDetail"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/NatureofOrganizationandOperationsAdditionalInformationDetail" xlink:type="extended" id="i70ba722d846941eabd662d92f7336278_NatureofOrganizationandOperationsAdditionalInformationDetail">
    <link:loc xlink:type="locator" xlink:label="loc_aadi_OrganizationConsolidationAndPresentationsOfFinancialStatementsLineItems_95af3e12-20d7-4c30-a38f-7ec4999098fd" xlink:href="aadi-20230331.xsd#aadi_OrganizationConsolidationAndPresentationsOfFinancialStatementsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_a73adcf8-416e-4666-be38-604677c5c63e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_OrganizationConsolidationAndPresentationsOfFinancialStatementsLineItems_95af3e12-20d7-4c30-a38f-7ec4999098fd" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_a73adcf8-416e-4666-be38-604677c5c63e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_e08236c6-3f46-49b6-8bc0-4899d60d3b32" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_OrganizationConsolidationAndPresentationsOfFinancialStatementsLineItems_95af3e12-20d7-4c30-a38f-7ec4999098fd" xlink:to="loc_us-gaap_NetIncomeLoss_e08236c6-3f46-49b6-8bc0-4899d60d3b32" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsAndShortTermInvestments_d515ce4d-f871-4f70-9daa-5f15ba7d4fe2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsAndShortTermInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_OrganizationConsolidationAndPresentationsOfFinancialStatementsLineItems_95af3e12-20d7-4c30-a38f-7ec4999098fd" xlink:to="loc_us-gaap_CashCashEquivalentsAndShortTermInvestments_d515ce4d-f871-4f70-9daa-5f15ba7d4fe2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_MaximumAggregateOfferingPrices_f6d5d543-be18-4a58-ae7e-4368f9f2a44f" xlink:href="aadi-20230331.xsd#aadi_MaximumAggregateOfferingPrices"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_OrganizationConsolidationAndPresentationsOfFinancialStatementsLineItems_95af3e12-20d7-4c30-a38f-7ec4999098fd" xlink:to="loc_aadi_MaximumAggregateOfferingPrices_f6d5d543-be18-4a58-ae7e-4368f9f2a44f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_54be9a24-6456-43e9-99dc-8045cdc7ab9e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_OrganizationConsolidationAndPresentationsOfFinancialStatementsLineItems_95af3e12-20d7-4c30-a38f-7ec4999098fd" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_54be9a24-6456-43e9-99dc-8045cdc7ab9e" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_OrganizationConsolidationAndPresentationsOfFinancialStatementsTable_43c84ad1-c74a-4fb3-a728-faa2039921e9" xlink:href="aadi-20230331.xsd#aadi_OrganizationConsolidationAndPresentationsOfFinancialStatementsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_aadi_OrganizationConsolidationAndPresentationsOfFinancialStatementsLineItems_95af3e12-20d7-4c30-a38f-7ec4999098fd" xlink:to="loc_aadi_OrganizationConsolidationAndPresentationsOfFinancialStatementsTable_43c84ad1-c74a-4fb3-a728-faa2039921e9" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_38ec530d-0c59-4dbd-bd5d-43bf5fc2c95e" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_aadi_OrganizationConsolidationAndPresentationsOfFinancialStatementsTable_43c84ad1-c74a-4fb3-a728-faa2039921e9" xlink:to="loc_srt_CounterpartyNameAxis_38ec530d-0c59-4dbd-bd5d-43bf5fc2c95e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_38ec530d-0c59-4dbd-bd5d-43bf5fc2c95e_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_38ec530d-0c59-4dbd-bd5d-43bf5fc2c95e" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_38ec530d-0c59-4dbd-bd5d-43bf5fc2c95e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_b87a5706-ed28-4f7f-a67c-cf6c4183c737" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_38ec530d-0c59-4dbd-bd5d-43bf5fc2c95e" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_b87a5706-ed28-4f7f-a67c-cf6c4183c737" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_CowenAndCompanyLLCMember_0e91cff3-7803-49e0-8fc3-159e39f6ec0a" xlink:href="aadi-20230331.xsd#aadi_CowenAndCompanyLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_b87a5706-ed28-4f7f-a67c-cf6c4183c737" xlink:to="loc_aadi_CowenAndCompanyLLCMember_0e91cff3-7803-49e0-8fc3-159e39f6ec0a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_92c99954-2d70-430c-8efa-6d067953e8b2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_aadi_OrganizationConsolidationAndPresentationsOfFinancialStatementsTable_43c84ad1-c74a-4fb3-a728-faa2039921e9" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_92c99954-2d70-430c-8efa-6d067953e8b2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_92c99954-2d70-430c-8efa-6d067953e8b2_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_92c99954-2d70-430c-8efa-6d067953e8b2" xlink:to="loc_us-gaap_EquityComponentDomain_92c99954-2d70-430c-8efa-6d067953e8b2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_6906e7ed-aa49-4052-9377-b9c415da9c26" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_92c99954-2d70-430c-8efa-6d067953e8b2" xlink:to="loc_us-gaap_EquityComponentDomain_6906e7ed-aa49-4052-9377-b9c415da9c26" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_4f754d27-72c5-499b-9d5e-3a587f0ea2f1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_6906e7ed-aa49-4052-9377-b9c415da9c26" xlink:to="loc_us-gaap_CommonStockMember_4f754d27-72c5-499b-9d5e-3a587f0ea2f1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_a80b2637-c213-4bd4-8555-8c312e5bc14f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_aadi_OrganizationConsolidationAndPresentationsOfFinancialStatementsTable_43c84ad1-c74a-4fb3-a728-faa2039921e9" xlink:to="loc_us-gaap_TypeOfArrangementAxis_a80b2637-c213-4bd4-8555-8c312e5bc14f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_a80b2637-c213-4bd4-8555-8c312e5bc14f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_a80b2637-c213-4bd4-8555-8c312e5bc14f" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_a80b2637-c213-4bd4-8555-8c312e5bc14f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_f05bc9ff-73b7-4378-aac0-4e57505983d3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_a80b2637-c213-4bd4-8555-8c312e5bc14f" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_f05bc9ff-73b7-4378-aac0-4e57505983d3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_SalesAgreementMember_c56a99f8-6434-4ce1-a85b-dd2e6c1ff25a" xlink:href="aadi-20230331.xsd#aadi_SalesAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_f05bc9ff-73b7-4378-aac0-4e57505983d3" xlink:to="loc_aadi_SalesAgreementMember_c56a99f8-6434-4ce1-a85b-dd2e6c1ff25a" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.aadi.com/role/SummaryofSignificantAccountingPoliciesAdditionalInformationDetail" xlink:type="simple" xlink:href="aadi-20230331.xsd#SummaryofSignificantAccountingPoliciesAdditionalInformationDetail"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/SummaryofSignificantAccountingPoliciesAdditionalInformationDetail" xlink:type="extended" id="ib1ed091d64a145b3bc3bb1408b9d1920_SummaryofSignificantAccountingPoliciesAdditionalInformationDetail">
    <link:loc xlink:type="locator" xlink:label="loc_aadi_SummaryOfSignificantAccountingPoliciesLineItems_f7038be9-f3d7-4e4d-b0a2-f76168f4f5a2" xlink:href="aadi-20230331.xsd#aadi_SummaryOfSignificantAccountingPoliciesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_79f11aae-078b-49db-add1-fe05aab3faf2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesLineItems_f7038be9-f3d7-4e4d-b0a2-f76168f4f5a2" xlink:to="loc_us-gaap_SharesOutstanding_79f11aae-078b-49db-add1-fe05aab3faf2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_e9b8bffd-2767-435e-b8a5-ca2e3da37c0b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesLineItems_f7038be9-f3d7-4e4d-b0a2-f76168f4f5a2" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_e9b8bffd-2767-435e-b8a5-ca2e3da37c0b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_7262a1ae-8f65-4e2c-b69d-96dd472bc428" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesLineItems_f7038be9-f3d7-4e4d-b0a2-f76168f4f5a2" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_7262a1ae-8f65-4e2c-b69d-96dd472bc428" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_d1518a7c-afe3-4d36-92a7-9f07e736b1c7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesLineItems_f7038be9-f3d7-4e4d-b0a2-f76168f4f5a2" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_d1518a7c-afe3-4d36-92a7-9f07e736b1c7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfOperatingSegments_0e66df83-5101-4784-84b5-8ad6516a5abb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NumberOfOperatingSegments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesLineItems_f7038be9-f3d7-4e4d-b0a2-f76168f4f5a2" xlink:to="loc_us-gaap_NumberOfOperatingSegments_0e66df83-5101-4784-84b5-8ad6516a5abb" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_028e43ce-f03a-4fea-a20f-1ea160d7d4f0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskPercentage1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesLineItems_f7038be9-f3d7-4e4d-b0a2-f76168f4f5a2" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_028e43ce-f03a-4fea-a20f-1ea160d7d4f0" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_f81d4c16-c9bd-41cb-869d-e407d2848564" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesLineItems_f7038be9-f3d7-4e4d-b0a2-f76168f4f5a2" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_f81d4c16-c9bd-41cb-869d-e407d2848564" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsPremiumsAndOtherReceivables_140b7496-6627-4924-b25a-8896dee752bb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AllowanceForDoubtfulAccountsPremiumsAndOtherReceivables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesLineItems_f7038be9-f3d7-4e4d-b0a2-f76168f4f5a2" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsPremiumsAndOtherReceivables_140b7496-6627-4924-b25a-8896dee752bb" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivable_41502955-a528-4ade-9600-dbd8b1f9a89d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesLineItems_f7038be9-f3d7-4e4d-b0a2-f76168f4f5a2" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivable_41502955-a528-4ade-9600-dbd8b1f9a89d" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableWriteOffs_4cd4aa14-1603-4e47-af31-a9b07770ebda" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableWriteOffs"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesLineItems_f7038be9-f3d7-4e4d-b0a2-f76168f4f5a2" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableWriteOffs_4cd4aa14-1603-4e47-af31-a9b07770ebda" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_190fc930-bb9a-467a-a9cd-85bb1e42c458" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesLineItems_f7038be9-f3d7-4e4d-b0a2-f76168f4f5a2" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_190fc930-bb9a-467a-a9cd-85bb1e42c458" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesChargedToCostAndExpense_72ca350b-8cad-4b22-90f4-2add019e1585" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowancesAndReservesChargedToCostAndExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesLineItems_f7038be9-f3d7-4e4d-b0a2-f76168f4f5a2" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesChargedToCostAndExpense_72ca350b-8cad-4b22-90f4-2add019e1585" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_406d6125-5d77-4c2d-9682-1dec6bc1a4a1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesLineItems_f7038be9-f3d7-4e4d-b0a2-f76168f4f5a2" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_406d6125-5d77-4c2d-9682-1dec6bc1a4a1" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_ShareBasedCompensationArrangementByShareBasedPaymentAwardStockPlanOfferingPeriod_771baacd-ff27-4b52-9090-9dfe710bf041" xlink:href="aadi-20230331.xsd#aadi_ShareBasedCompensationArrangementByShareBasedPaymentAwardStockPlanOfferingPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesLineItems_f7038be9-f3d7-4e4d-b0a2-f76168f4f5a2" xlink:to="loc_aadi_ShareBasedCompensationArrangementByShareBasedPaymentAwardStockPlanOfferingPeriod_771baacd-ff27-4b52-9090-9dfe710bf041" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_8c3269ed-7e72-42f8-bc26-edfa0caa0f1f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesLineItems_f7038be9-f3d7-4e4d-b0a2-f76168f4f5a2" xlink:to="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_8c3269ed-7e72-42f8-bc26-edfa0caa0f1f" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_8722195f-688b-42bd-b283-b2ce86dc709d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesLineItems_f7038be9-f3d7-4e4d-b0a2-f76168f4f5a2" xlink:to="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_8722195f-688b-42bd-b283-b2ce86dc709d" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_SummaryOfSignificantAccountingPoliciesTable_a7d8a251-c808-4e35-bdf7-d1186858a794" xlink:href="aadi-20230331.xsd#aadi_SummaryOfSignificantAccountingPoliciesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesLineItems_f7038be9-f3d7-4e4d-b0a2-f76168f4f5a2" xlink:to="loc_aadi_SummaryOfSignificantAccountingPoliciesTable_a7d8a251-c808-4e35-bdf7-d1186858a794" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MajorCustomersAxis_9cc51696-6571-45f9-a16e-d6ed19d298e4" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MajorCustomersAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesTable_a7d8a251-c808-4e35-bdf7-d1186858a794" xlink:to="loc_srt_MajorCustomersAxis_9cc51696-6571-45f9-a16e-d6ed19d298e4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NameOfMajorCustomerDomain_9cc51696-6571-45f9-a16e-d6ed19d298e4_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_NameOfMajorCustomerDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_MajorCustomersAxis_9cc51696-6571-45f9-a16e-d6ed19d298e4" xlink:to="loc_srt_NameOfMajorCustomerDomain_9cc51696-6571-45f9-a16e-d6ed19d298e4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NameOfMajorCustomerDomain_999686a7-1209-4edc-a9b5-6796683f45cb" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_NameOfMajorCustomerDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_MajorCustomersAxis_9cc51696-6571-45f9-a16e-d6ed19d298e4" xlink:to="loc_srt_NameOfMajorCustomerDomain_999686a7-1209-4edc-a9b5-6796683f45cb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_CompanyOneMember_faf2d278-d057-4ab3-87c5-98a49fec656e" xlink:href="aadi-20230331.xsd#aadi_CompanyOneMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_999686a7-1209-4edc-a9b5-6796683f45cb" xlink:to="loc_aadi_CompanyOneMember_faf2d278-d057-4ab3-87c5-98a49fec656e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_CompanyTwoMember_7a4cdd6d-39a4-4546-99c5-52af3eb42c81" xlink:href="aadi-20230331.xsd#aadi_CompanyTwoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_999686a7-1209-4edc-a9b5-6796683f45cb" xlink:to="loc_aadi_CompanyTwoMember_7a4cdd6d-39a4-4546-99c5-52af3eb42c81" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_CustomerOneMember_259a410e-6728-4001-acba-c5e0a410399c" xlink:href="aadi-20230331.xsd#aadi_CustomerOneMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_999686a7-1209-4edc-a9b5-6796683f45cb" xlink:to="loc_aadi_CustomerOneMember_259a410e-6728-4001-acba-c5e0a410399c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_CustomerTwoMember_362eee0d-86cd-4675-bb28-b8837f1703d5" xlink:href="aadi-20230331.xsd#aadi_CustomerTwoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_999686a7-1209-4edc-a9b5-6796683f45cb" xlink:to="loc_aadi_CustomerTwoMember_362eee0d-86cd-4675-bb28-b8837f1703d5" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_eee32bbd-9840-4a12-a45a-92497d051671" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesTable_a7d8a251-c808-4e35-bdf7-d1186858a794" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_eee32bbd-9840-4a12-a45a-92497d051671" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_eee32bbd-9840-4a12-a45a-92497d051671_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_eee32bbd-9840-4a12-a45a-92497d051671" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_eee32bbd-9840-4a12-a45a-92497d051671_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_25d61af8-a0fa-4833-b797-1dc153e820d1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_eee32bbd-9840-4a12-a45a-92497d051671" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_25d61af8-a0fa-4833-b797-1dc153e820d1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesRevenueNetMember_7c3bd47e-a061-4825-b7dd-b7e0c72dded0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SalesRevenueNetMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_25d61af8-a0fa-4833-b797-1dc153e820d1" xlink:to="loc_us-gaap_SalesRevenueNetMember_7c3bd47e-a061-4825-b7dd-b7e0c72dded0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableMember_b8ababb6-15d8-4ff8-86a9-f5a45c3bcac6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsReceivableMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_25d61af8-a0fa-4833-b797-1dc153e820d1" xlink:to="loc_us-gaap_AccountsReceivableMember_b8ababb6-15d8-4ff8-86a9-f5a45c3bcac6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_5fcb9221-1477-4ecc-8ea6-4ef51fff9b93" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesTable_a7d8a251-c808-4e35-bdf7-d1186858a794" xlink:to="loc_us-gaap_ConcentrationRiskByTypeAxis_5fcb9221-1477-4ecc-8ea6-4ef51fff9b93" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_5fcb9221-1477-4ecc-8ea6-4ef51fff9b93_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_5fcb9221-1477-4ecc-8ea6-4ef51fff9b93" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_5fcb9221-1477-4ecc-8ea6-4ef51fff9b93_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_231b87d4-474c-4716-9623-247072c392ee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_5fcb9221-1477-4ecc-8ea6-4ef51fff9b93" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_231b87d4-474c-4716-9623-247072c392ee" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CustomerConcentrationRiskMember_ed255e4f-15d0-4eb0-bc5a-283563e9aa68" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CustomerConcentrationRiskMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_231b87d4-474c-4716-9623-247072c392ee" xlink:to="loc_us-gaap_CustomerConcentrationRiskMember_ed255e4f-15d0-4eb0-bc5a-283563e9aa68" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAxis_ad160009-9808-4e5d-b112-b7a103e2b70b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesTable_a7d8a251-c808-4e35-bdf7-d1186858a794" xlink:to="loc_us-gaap_CashAndCashEquivalentsAxis_ad160009-9808-4e5d-b112-b7a103e2b70b" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_ad160009-9808-4e5d-b112-b7a103e2b70b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_ad160009-9808-4e5d-b112-b7a103e2b70b" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_ad160009-9808-4e5d-b112-b7a103e2b70b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_26c68ee3-7fdd-4609-8665-e2613dffa0f0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_ad160009-9808-4e5d-b112-b7a103e2b70b" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_26c68ee3-7fdd-4609-8665-e2613dffa0f0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_5e8030d3-6377-474a-a308-2a6baa65836f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_26c68ee3-7fdd-4609-8665-e2613dffa0f0" xlink:to="loc_us-gaap_MoneyMarketFundsMember_5e8030d3-6377-474a-a308-2a6baa65836f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_a72a4e3a-be4d-4a29-83f0-0e776b4b3549" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesTable_a7d8a251-c808-4e35-bdf7-d1186858a794" xlink:to="loc_srt_RangeAxis_a72a4e3a-be4d-4a29-83f0-0e776b4b3549" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_a72a4e3a-be4d-4a29-83f0-0e776b4b3549_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_a72a4e3a-be4d-4a29-83f0-0e776b4b3549" xlink:to="loc_srt_RangeMember_a72a4e3a-be4d-4a29-83f0-0e776b4b3549_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_6ac0acc6-661b-48c1-9689-61410ed5152a" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_a72a4e3a-be4d-4a29-83f0-0e776b4b3549" xlink:to="loc_srt_RangeMember_6ac0acc6-661b-48c1-9689-61410ed5152a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_fb224df0-d512-4b72-8be4-e1e030553fb0" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_6ac0acc6-661b-48c1-9689-61410ed5152a" xlink:to="loc_srt_MinimumMember_fb224df0-d512-4b72-8be4-e1e030553fb0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_a669f1a3-ac71-4ee7-9fbb-7c1cdaff389b" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_6ac0acc6-661b-48c1-9689-61410ed5152a" xlink:to="loc_srt_MaximumMember_a669f1a3-ac71-4ee7-9fbb-7c1cdaff389b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_38344874-63c7-401d-a600-3224746447d4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowancesAndReservesTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesTable_a7d8a251-c808-4e35-bdf7-d1186858a794" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_38344874-63c7-401d-a600-3224746447d4" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesDomain_38344874-63c7-401d-a600-3224746447d4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowancesAndReservesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_38344874-63c7-401d-a600-3224746447d4" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesDomain_38344874-63c7-401d-a600-3224746447d4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesDomain_23c35e92-904b-44dc-ad9c-4b67a3999d5c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowancesAndReservesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_38344874-63c7-401d-a600-3224746447d4" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesDomain_23c35e92-904b-44dc-ad9c-4b67a3999d5c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_ProductSalesAllowanceMember_1264cacc-248f-465e-8e83-45c314e24419" xlink:href="aadi-20230331.xsd#aadi_ProductSalesAllowanceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesDomain_23c35e92-904b-44dc-ad9c-4b67a3999d5c" xlink:to="loc_aadi_ProductSalesAllowanceMember_1264cacc-248f-465e-8e83-45c314e24419" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_af037fda-e4a6-403b-bf2c-4f764477ec30" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesTable_a7d8a251-c808-4e35-bdf7-d1186858a794" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_af037fda-e4a6-403b-bf2c-4f764477ec30" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_af037fda-e4a6-403b-bf2c-4f764477ec30_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_af037fda-e4a6-403b-bf2c-4f764477ec30" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_af037fda-e4a6-403b-bf2c-4f764477ec30_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_5e1eea97-e927-4a77-a230-c0d10bdbcae2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_af037fda-e4a6-403b-bf2c-4f764477ec30" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_5e1eea97-e927-4a77-a230-c0d10bdbcae2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_PrivatePlacementFinancingMember_6478343c-ff43-4d8e-b6b3-dd61e00f2a0a" xlink:href="aadi-20230331.xsd#aadi_PrivatePlacementFinancingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_5e1eea97-e927-4a77-a230-c0d10bdbcae2" xlink:to="loc_aadi_PrivatePlacementFinancingMember_6478343c-ff43-4d8e-b6b3-dd61e00f2a0a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_4e1e1baf-e427-494c-96dd-ccaf8d51f6c1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesTable_a7d8a251-c808-4e35-bdf7-d1186858a794" xlink:to="loc_us-gaap_TypeOfArrangementAxis_4e1e1baf-e427-494c-96dd-ccaf8d51f6c1" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_4e1e1baf-e427-494c-96dd-ccaf8d51f6c1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_4e1e1baf-e427-494c-96dd-ccaf8d51f6c1" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_4e1e1baf-e427-494c-96dd-ccaf8d51f6c1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_10167916-ba23-49de-bdba-fc6637f0d3e3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_4e1e1baf-e427-494c-96dd-ccaf8d51f6c1" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_10167916-ba23-49de-bdba-fc6637f0d3e3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_PurchaseAgreementMember_d783efa3-8982-4db2-ac6a-f062295009be" xlink:href="aadi-20230331.xsd#aadi_PurchaseAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_10167916-ba23-49de-bdba-fc6637f0d3e3" xlink:to="loc_aadi_PurchaseAgreementMember_d783efa3-8982-4db2-ac6a-f062295009be" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_77672215-e08a-417f-bc39-07d1889bc025" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesTable_a7d8a251-c808-4e35-bdf7-d1186858a794" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_77672215-e08a-417f-bc39-07d1889bc025" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_77672215-e08a-417f-bc39-07d1889bc025_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_77672215-e08a-417f-bc39-07d1889bc025" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_77672215-e08a-417f-bc39-07d1889bc025_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_43afdfa9-968f-40ca-92d7-e23f0a19819d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_77672215-e08a-417f-bc39-07d1889bc025" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_43afdfa9-968f-40ca-92d7-e23f0a19819d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_PreFundedWarrantMember_b92057d6-0597-4d90-b672-0144a19126ab" xlink:href="aadi-20230331.xsd#aadi_PreFundedWarrantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_43afdfa9-968f-40ca-92d7-e23f0a19819d" xlink:to="loc_aadi_PreFundedWarrantMember_b92057d6-0597-4d90-b672-0144a19126ab" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.aadi.com/role/SummaryofSignificantAccountingPoliciesPropertyandEquipmentDetails" xlink:type="simple" xlink:href="aadi-20230331.xsd#SummaryofSignificantAccountingPoliciesPropertyandEquipmentDetails"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/SummaryofSignificantAccountingPoliciesPropertyandEquipmentDetails" xlink:type="extended" id="i0ef75439d2e54fa4a1c80cb9a26ee5f3_SummaryofSignificantAccountingPoliciesPropertyandEquipmentDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_31e0164f-b429-4f4e-b9d2-a81be3a33e7d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_abe066da-1e87-4142-a238-66cd6c24382d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_31e0164f-b429-4f4e-b9d2-a81be3a33e7d" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_abe066da-1e87-4142-a238-66cd6c24382d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_14af3649-0283-4f03-a250-5a8f76a9321d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_31e0164f-b429-4f4e-b9d2-a81be3a33e7d" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_14af3649-0283-4f03-a250-5a8f76a9321d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_82871f9d-7da6-4ba4-acfc-140b7c757501" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_31e0164f-b429-4f4e-b9d2-a81be3a33e7d" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_82871f9d-7da6-4ba4-acfc-140b7c757501" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_8f76f4db-1756-4c52-a176-0d26feb9f8ee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_31e0164f-b429-4f4e-b9d2-a81be3a33e7d" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_8f76f4db-1756-4c52-a176-0d26feb9f8ee" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_40b13bdf-2643-46fe-8593-3beb4c3c1590" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_8f76f4db-1756-4c52-a176-0d26feb9f8ee" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_40b13bdf-2643-46fe-8593-3beb4c3c1590" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_40b13bdf-2643-46fe-8593-3beb4c3c1590_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_40b13bdf-2643-46fe-8593-3beb4c3c1590" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_40b13bdf-2643-46fe-8593-3beb4c3c1590_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_8b86af9f-b18a-4985-821f-caf7f822fc4c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_40b13bdf-2643-46fe-8593-3beb4c3c1590" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_8b86af9f-b18a-4985-821f-caf7f822fc4c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_ComputerEquipmentAndSoftwareMember_046e6b5b-f1ed-490a-89ec-6f807be2f63d" xlink:href="aadi-20230331.xsd#aadi_ComputerEquipmentAndSoftwareMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_8b86af9f-b18a-4985-821f-caf7f822fc4c" xlink:to="loc_aadi_ComputerEquipmentAndSoftwareMember_046e6b5b-f1ed-490a-89ec-6f807be2f63d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConstructionInProgressMember_d2a2cc8e-c08b-40ee-b366-68c40eefaef8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConstructionInProgressMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_8b86af9f-b18a-4985-821f-caf7f822fc4c" xlink:to="loc_us-gaap_ConstructionInProgressMember_d2a2cc8e-c08b-40ee-b366-68c40eefaef8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FurnitureAndFixturesMember_13ee25fa-250d-4360-94f4-5c64799e8683" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FurnitureAndFixturesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_8b86af9f-b18a-4985-821f-caf7f822fc4c" xlink:to="loc_us-gaap_FurnitureAndFixturesMember_13ee25fa-250d-4360-94f4-5c64799e8683" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseholdImprovementsMember_77625213-150b-4b53-a913-c842f70e5338" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeaseholdImprovementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_8b86af9f-b18a-4985-821f-caf7f822fc4c" xlink:to="loc_us-gaap_LeaseholdImprovementsMember_77625213-150b-4b53-a913-c842f70e5338" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.aadi.com/role/SummaryofSignificantAccountingPoliciesGrosstoNetSalesAdjustmentsDetails" xlink:type="simple" xlink:href="aadi-20230331.xsd#SummaryofSignificantAccountingPoliciesGrosstoNetSalesAdjustmentsDetails"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/SummaryofSignificantAccountingPoliciesGrosstoNetSalesAdjustmentsDetails" xlink:type="extended" id="i3fa821245c364bc89ac8a0392f864994_SummaryofSignificantAccountingPoliciesGrosstoNetSalesAdjustmentsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_srt_ValuationAndQualifyingAccountsDisclosureLineItems_b3d7e797-8d03-4fe1-9c97-db305199c796" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ValuationAndQualifyingAccountsDisclosureLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_4bac935c-e77b-47fe-8e94-ba2978e15744" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MovementInValuationAllowancesAndReservesRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureLineItems_b3d7e797-8d03-4fe1-9c97-db305199c796" xlink:to="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_4bac935c-e77b-47fe-8e94-ba2978e15744" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesBalance_028ebefd-8110-4268-94db-bf62cb3e9845" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowancesAndReservesBalance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_4bac935c-e77b-47fe-8e94-ba2978e15744" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesBalance_028ebefd-8110-4268-94db-bf62cb3e9845" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesChargedToCostAndExpense_998d4102-b96a-4159-b883-58c4a2693434" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowancesAndReservesChargedToCostAndExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_4bac935c-e77b-47fe-8e94-ba2978e15744" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesChargedToCostAndExpense_998d4102-b96a-4159-b883-58c4a2693434" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_SECSchedule1209ValuationAllowancesAndReservesPayments_3fce30d2-f47a-4751-b183-0ab84dd3f524" xlink:href="aadi-20230331.xsd#aadi_SECSchedule1209ValuationAllowancesAndReservesPayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_4bac935c-e77b-47fe-8e94-ba2978e15744" xlink:to="loc_aadi_SECSchedule1209ValuationAllowancesAndReservesPayments_3fce30d2-f47a-4751-b183-0ab84dd3f524" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesBalance_6e2b2b0f-68d7-43cb-8bfe-cbb3dcb4894b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowancesAndReservesBalance"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ValuationAndQualifyingAccountsDisclosureTable_2afd476b-18fb-4e33-a94f-758d1118c925" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ValuationAndQualifyingAccountsDisclosureTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureLineItems_b3d7e797-8d03-4fe1-9c97-db305199c796" xlink:to="loc_srt_ValuationAndQualifyingAccountsDisclosureTable_2afd476b-18fb-4e33-a94f-758d1118c925" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_9d127ab9-f82a-40e7-aea5-54f94a850369" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowancesAndReservesTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureTable_2afd476b-18fb-4e33-a94f-758d1118c925" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_9d127ab9-f82a-40e7-aea5-54f94a850369" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesDomain_9d127ab9-f82a-40e7-aea5-54f94a850369_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowancesAndReservesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_9d127ab9-f82a-40e7-aea5-54f94a850369" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesDomain_9d127ab9-f82a-40e7-aea5-54f94a850369_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesDomain_528e8179-8892-4d7e-b196-b43015d83c74" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowancesAndReservesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_9d127ab9-f82a-40e7-aea5-54f94a850369" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesDomain_528e8179-8892-4d7e-b196-b43015d83c74" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_ProductSalesAllowanceMember_35a55b2b-32f5-4251-ab85-ae91e6098380" xlink:href="aadi-20230331.xsd#aadi_ProductSalesAllowanceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesDomain_528e8179-8892-4d7e-b196-b43015d83c74" xlink:to="loc_aadi_ProductSalesAllowanceMember_35a55b2b-32f5-4251-ab85-ae91e6098380" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.aadi.com/role/SummaryofSignificantAccountingPoliciesScheduleofOutstandingPotentiallyDilutiveSecuritiesExcludedinCalculationofDilutedNetLossperShareDetail" xlink:type="simple" xlink:href="aadi-20230331.xsd#SummaryofSignificantAccountingPoliciesScheduleofOutstandingPotentiallyDilutiveSecuritiesExcludedinCalculationofDilutedNetLossperShareDetail"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/SummaryofSignificantAccountingPoliciesScheduleofOutstandingPotentiallyDilutiveSecuritiesExcludedinCalculationofDilutedNetLossperShareDetail" xlink:type="extended" id="i665a6b80791e4eed9b0d2c8d2cdccda0_SummaryofSignificantAccountingPoliciesScheduleofOutstandingPotentiallyDilutiveSecuritiesExcludedinCalculationofDilutedNetLossperShareDetail">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_fd97c9ce-9ba4-4098-8090-fd462f81ae43" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_03d7c298-f6f2-4c73-ac0e-967ae1afbc36" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_fd97c9ce-9ba4-4098-8090-fd462f81ae43" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_03d7c298-f6f2-4c73-ac0e-967ae1afbc36" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_40a67fc0-99bb-4c76-876b-6e79bc77df88" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_fd97c9ce-9ba4-4098-8090-fd462f81ae43" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_40a67fc0-99bb-4c76-876b-6e79bc77df88" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_ae260f45-706c-466b-bc35-ed9ed48cc3c8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_40a67fc0-99bb-4c76-876b-6e79bc77df88" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_ae260f45-706c-466b-bc35-ed9ed48cc3c8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_ae260f45-706c-466b-bc35-ed9ed48cc3c8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_ae260f45-706c-466b-bc35-ed9ed48cc3c8" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_ae260f45-706c-466b-bc35-ed9ed48cc3c8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_50981448-4994-4c6c-8a98-e75a954a0d24" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_ae260f45-706c-466b-bc35-ed9ed48cc3c8" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_50981448-4994-4c6c-8a98-e75a954a0d24" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_ca724939-2e39-4fc3-8e74-e3a1600636e9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_50981448-4994-4c6c-8a98-e75a954a0d24" xlink:to="loc_us-gaap_EmployeeStockOptionMember_ca724939-2e39-4fc3-8e74-e3a1600636e9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantMember_4acb65ba-2b0d-4d27-8b2e-b7d0fdee3338" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WarrantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_50981448-4994-4c6c-8a98-e75a954a0d24" xlink:to="loc_us-gaap_WarrantMember_4acb65ba-2b0d-4d27-8b2e-b7d0fdee3338" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.aadi.com/role/FairValueMeasurementDetails" xlink:type="simple" xlink:href="aadi-20230331.xsd#FairValueMeasurementDetails"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/FairValueMeasurementDetails" xlink:type="extended" id="i194d8ce1e34844538d501bcdf18b2a3d_FairValueMeasurementDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_7a0b4ce7-39da-40d5-9d44-8bc8be9bc0c2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_45e905b1-ca86-45bb-8567-bb14746056ef" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_7a0b4ce7-39da-40d5-9d44-8bc8be9bc0c2" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_45e905b1-ca86-45bb-8567-bb14746056ef" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_0e3a8190-ea02-4a16-b26d-69c97595e3f7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_7a0b4ce7-39da-40d5-9d44-8bc8be9bc0c2" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_0e3a8190-ea02-4a16-b26d-69c97595e3f7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedGainLossBeforeTax_77ea86f2-f90c-4eba-8fcf-dee133793422" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedGainLossBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_7a0b4ce7-39da-40d5-9d44-8bc8be9bc0c2" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedGainLossBeforeTax_77ea86f2-f90c-4eba-8fcf-dee133793422" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_feea20b0-8bfb-4816-a560-5ff8c16ac3b5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_7a0b4ce7-39da-40d5-9d44-8bc8be9bc0c2" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_feea20b0-8bfb-4816-a560-5ff8c16ac3b5" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_aec64773-928d-483a-8f99-9edc97b2a07d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByMeasurementFrequencyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_feea20b0-8bfb-4816-a560-5ff8c16ac3b5" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_aec64773-928d-483a-8f99-9edc97b2a07d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_aec64773-928d-483a-8f99-9edc97b2a07d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_aec64773-928d-483a-8f99-9edc97b2a07d" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_aec64773-928d-483a-8f99-9edc97b2a07d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_c9ec3895-90b0-4837-8a2f-3f6b86f148b0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_aec64773-928d-483a-8f99-9edc97b2a07d" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_c9ec3895-90b0-4837-8a2f-3f6b86f148b0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_e085ab6e-e3c5-434b-b740-b167acd99031" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsRecurringMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_c9ec3895-90b0-4837-8a2f-3f6b86f148b0" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_e085ab6e-e3c5-434b-b740-b167acd99031" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_60519456-59e9-45fb-98ea-f8876850ea0e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_feea20b0-8bfb-4816-a560-5ff8c16ac3b5" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_60519456-59e9-45fb-98ea-f8876850ea0e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_60519456-59e9-45fb-98ea-f8876850ea0e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_60519456-59e9-45fb-98ea-f8876850ea0e" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_60519456-59e9-45fb-98ea-f8876850ea0e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_de70da92-0e0c-41fe-a62a-1ff651ad0514" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_60519456-59e9-45fb-98ea-f8876850ea0e" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_de70da92-0e0c-41fe-a62a-1ff651ad0514" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_186a5fad-0b05-4c12-a2d1-ace973c09a6a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_de70da92-0e0c-41fe-a62a-1ff651ad0514" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_186a5fad-0b05-4c12-a2d1-ace973c09a6a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_9a433090-65a8-451c-bba0-5d439619c233" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_de70da92-0e0c-41fe-a62a-1ff651ad0514" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_9a433090-65a8-451c-bba0-5d439619c233" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_01f3ae76-1c07-412d-b018-bd36cabcdd81" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_de70da92-0e0c-41fe-a62a-1ff651ad0514" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_01f3ae76-1c07-412d-b018-bd36cabcdd81" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_77ebc195-f3bd-481a-86d0-c23f5ccdf68a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_feea20b0-8bfb-4816-a560-5ff8c16ac3b5" xlink:to="loc_us-gaap_FinancialInstrumentAxis_77ebc195-f3bd-481a-86d0-c23f5ccdf68a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_77ebc195-f3bd-481a-86d0-c23f5ccdf68a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_77ebc195-f3bd-481a-86d0-c23f5ccdf68a" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_77ebc195-f3bd-481a-86d0-c23f5ccdf68a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_f01cb33c-0258-4e01-9062-57781d72121e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_77ebc195-f3bd-481a-86d0-c23f5ccdf68a" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_f01cb33c-0258-4e01-9062-57781d72121e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_7b602137-7637-4ae1-8afa-6b7363f5902f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_f01cb33c-0258-4e01-9062-57781d72121e" xlink:to="loc_us-gaap_MoneyMarketFundsMember_7b602137-7637-4ae1-8afa-6b7363f5902f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_84313f94-a700-402b-bd39-40176456bf98" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_f01cb33c-0258-4e01-9062-57781d72121e" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_84313f94-a700-402b-bd39-40176456bf98" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperMember_f3872a1d-c5b7-4b8c-947a-6b23b92a62ab" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommercialPaperMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_f01cb33c-0258-4e01-9062-57781d72121e" xlink:to="loc_us-gaap_CommercialPaperMember_f3872a1d-c5b7-4b8c-947a-6b23b92a62ab" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_e067c5cf-e3b0-4b24-8900-0a9dd8a6e9e8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CorporateDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_f01cb33c-0258-4e01-9062-57781d72121e" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_e067c5cf-e3b0-4b24-8900-0a9dd8a6e9e8" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_6776db99-06d2-4736-976e-c498d12d6398" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_f01cb33c-0258-4e01-9062-57781d72121e" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_6776db99-06d2-4736-976e-c498d12d6398" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.aadi.com/role/ShortTermInvestmentsandCashEquivalentsDetails" xlink:type="simple" xlink:href="aadi-20230331.xsd#ShortTermInvestmentsandCashEquivalentsDetails"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/ShortTermInvestmentsandCashEquivalentsDetails" xlink:type="extended" id="i59b212fd20b34176a516e04d8a509ec2_ShortTermInvestmentsandCashEquivalentsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_4b4fab1c-e347-4c65-8828-1415e5662481" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_dca5b43e-44e6-4cdd-bf2a-2ad728ee8680" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_4b4fab1c-e347-4c65-8828-1415e5662481" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_dca5b43e-44e6-4cdd-bf2a-2ad728ee8680" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_2d79c3c5-979d-4189-aa8f-0faccee7cf2e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_4b4fab1c-e347-4c65-8828-1415e5662481" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_2d79c3c5-979d-4189-aa8f-0faccee7cf2e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_24613985-d63c-47a6-baf9-df41d4abd7b9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_4b4fab1c-e347-4c65-8828-1415e5662481" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_24613985-d63c-47a6-baf9-df41d4abd7b9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_aae9ff24-3656-4cb3-a596-ff7583923a6b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_4b4fab1c-e347-4c65-8828-1415e5662481" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_aae9ff24-3656-4cb3-a596-ff7583923a6b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_b33e0c55-1d45-4d4f-8f3b-bbf80828e264" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_4b4fab1c-e347-4c65-8828-1415e5662481" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_b33e0c55-1d45-4d4f-8f3b-bbf80828e264" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_9a1e637a-2e31-4fd5-b15d-444bf1cb7f3a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_b33e0c55-1d45-4d4f-8f3b-bbf80828e264" xlink:to="loc_us-gaap_FinancialInstrumentAxis_9a1e637a-2e31-4fd5-b15d-444bf1cb7f3a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_9a1e637a-2e31-4fd5-b15d-444bf1cb7f3a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_9a1e637a-2e31-4fd5-b15d-444bf1cb7f3a" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_9a1e637a-2e31-4fd5-b15d-444bf1cb7f3a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_af9a46ee-b949-45c3-8e88-0b54f9ab219c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_9a1e637a-2e31-4fd5-b15d-444bf1cb7f3a" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_af9a46ee-b949-45c3-8e88-0b54f9ab219c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_f4c804f6-43ec-468f-88ac-01d66cca147d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_af9a46ee-b949-45c3-8e88-0b54f9ab219c" xlink:to="loc_us-gaap_MoneyMarketFundsMember_f4c804f6-43ec-468f-88ac-01d66cca147d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_5509f25b-057f-4962-9834-c90514e6176d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_af9a46ee-b949-45c3-8e88-0b54f9ab219c" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_5509f25b-057f-4962-9834-c90514e6176d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperMember_626e02f5-e2e1-4407-84dc-35793118797f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommercialPaperMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_af9a46ee-b949-45c3-8e88-0b54f9ab219c" xlink:to="loc_us-gaap_CommercialPaperMember_626e02f5-e2e1-4407-84dc-35793118797f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_2fa0e222-f385-4efc-87a7-835eae94bfb7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CorporateDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_af9a46ee-b949-45c3-8e88-0b54f9ab219c" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_2fa0e222-f385-4efc-87a7-835eae94bfb7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_338bf6d6-a57a-46eb-84fc-e51b484402c3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_af9a46ee-b949-45c3-8e88-0b54f9ab219c" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_338bf6d6-a57a-46eb-84fc-e51b484402c3" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.aadi.com/role/OperatingLeaseAdditionalInformationDetail" xlink:type="simple" xlink:href="aadi-20230331.xsd#OperatingLeaseAdditionalInformationDetail"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/OperatingLeaseAdditionalInformationDetail" xlink:type="extended" id="i0b88dda0ebeb4e4295793b0632b8c251_OperatingLeaseAdditionalInformationDetail">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionLineItems_99e55bdf-fcd0-4f50-bf91-42efa568073a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeLeaseDescriptionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseTermOfContract_1465b432-faf1-4ea6-9032-95436efbbe1e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseTermOfContract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_99e55bdf-fcd0-4f50-bf91-42efa568073a" xlink:to="loc_us-gaap_LesseeOperatingLeaseTermOfContract_1465b432-faf1-4ea6-9032-95436efbbe1e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_OperatingLeaseRentAbatementPeriod_d2c7ab4c-687b-4fbe-90be-075910e4c85b" xlink:href="aadi-20230331.xsd#aadi_OperatingLeaseRentAbatementPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_99e55bdf-fcd0-4f50-bf91-42efa568073a" xlink:to="loc_aadi_OperatingLeaseRentAbatementPeriod_d2c7ab4c-687b-4fbe-90be-075910e4c85b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseRenewalTerm_c0f84171-58a6-45b9-977b-280f4d0f4586" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseRenewalTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_99e55bdf-fcd0-4f50-bf91-42efa568073a" xlink:to="loc_us-gaap_LesseeOperatingLeaseRenewalTerm_c0f84171-58a6-45b9-977b-280f4d0f4586" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_LesseeOperatingLeaseExtendTermForAdditionalPeriod_addab4e8-9f06-42a3-b64d-b58b56448acb" xlink:href="aadi-20230331.xsd#aadi_LesseeOperatingLeaseExtendTermForAdditionalPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_99e55bdf-fcd0-4f50-bf91-42efa568073a" xlink:to="loc_aadi_LesseeOperatingLeaseExtendTermForAdditionalPeriod_addab4e8-9f06-42a3-b64d-b58b56448acb" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_LesseeOperatingLeaseRentEscalationPercentage_e47ee7c7-7056-413b-bc45-f02e8628593a" xlink:href="aadi-20230331.xsd#aadi_LesseeOperatingLeaseRentEscalationPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_99e55bdf-fcd0-4f50-bf91-42efa568073a" xlink:to="loc_aadi_LesseeOperatingLeaseRentEscalationPercentage_e47ee7c7-7056-413b-bc45-f02e8628593a" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionTable_678d16a8-c2f6-4dca-bac6-4a445fedd849" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeLeaseDescriptionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_99e55bdf-fcd0-4f50-bf91-42efa568073a" xlink:to="loc_us-gaap_LesseeLeaseDescriptionTable_678d16a8-c2f6-4dca-bac6-4a445fedd849" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_98463e34-0770-42ff-9989-0f824047eba5" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_678d16a8-c2f6-4dca-bac6-4a445fedd849" xlink:to="loc_srt_StatementGeographicalAxis_98463e34-0770-42ff-9989-0f824047eba5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_98463e34-0770-42ff-9989-0f824047eba5_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_98463e34-0770-42ff-9989-0f824047eba5" xlink:to="loc_srt_SegmentGeographicalDomain_98463e34-0770-42ff-9989-0f824047eba5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_60a8bdcd-5b31-4c18-a0d4-ee267f1b91b4" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_98463e34-0770-42ff-9989-0f824047eba5" xlink:to="loc_srt_SegmentGeographicalDomain_60a8bdcd-5b31-4c18-a0d4-ee267f1b91b4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_stpr_CA_683eba53-7926-485f-ac28-b08f37893863" xlink:href="https://xbrl.sec.gov/stpr/2022/stpr-2022.xsd#stpr_CA"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_60a8bdcd-5b31-4c18-a0d4-ee267f1b91b4" xlink:to="loc_stpr_CA_683eba53-7926-485f-ac28-b08f37893863" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_stpr_NJ_dfc66de7-a8a7-4ffe-a165-f823ee7bc35c" xlink:href="https://xbrl.sec.gov/stpr/2022/stpr-2022.xsd#stpr_NJ"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_60a8bdcd-5b31-4c18-a0d4-ee267f1b91b4" xlink:to="loc_stpr_NJ_dfc66de7-a8a7-4ffe-a165-f823ee7bc35c" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.aadi.com/role/LicenseAgreementsAdditionalInformationDetail" xlink:type="simple" xlink:href="aadi-20230331.xsd#LicenseAgreementsAdditionalInformationDetail"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/LicenseAgreementsAdditionalInformationDetail" xlink:type="extended" id="ice145677bd0c4647b0ce4ab8dfe5a95f_LicenseAgreementsAdditionalInformationDetail">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CapitalizedContractCostLineItems_30c367fb-14a8-4326-9d22-c74d09ab219f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CapitalizedContractCostLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_RoyaltiesWereAccruedOnProductSales_7a34a488-9541-40b7-a493-f3393c8a5e72" xlink:href="aadi-20230331.xsd#aadi_RoyaltiesWereAccruedOnProductSales"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CapitalizedContractCostLineItems_30c367fb-14a8-4326-9d22-c74d09ab219f" xlink:to="loc_aadi_RoyaltiesWereAccruedOnProductSales_7a34a488-9541-40b7-a493-f3393c8a5e72" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_PaymentsRelatedToMilestone_4757f433-9927-4ffb-af10-84255d857beb" xlink:href="aadi-20230331.xsd#aadi_PaymentsRelatedToMilestone"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CapitalizedContractCostLineItems_30c367fb-14a8-4326-9d22-c74d09ab219f" xlink:to="loc_aadi_PaymentsRelatedToMilestone_4757f433-9927-4ffb-af10-84255d857beb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_PaymentOfLicenseFees_1fe9a912-d17e-4810-aad3-c70270afd751" xlink:href="aadi-20230331.xsd#aadi_PaymentOfLicenseFees"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CapitalizedContractCostLineItems_30c367fb-14a8-4326-9d22-c74d09ab219f" xlink:to="loc_aadi_PaymentOfLicenseFees_1fe9a912-d17e-4810-aad3-c70270afd751" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_LicenseFeesIncludingPercentageOfOutstandingPaymentObligation_e38ec9af-9f01-4dae-9666-2bbe08961a16" xlink:href="aadi-20230331.xsd#aadi_LicenseFeesIncludingPercentageOfOutstandingPaymentObligation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CapitalizedContractCostLineItems_30c367fb-14a8-4326-9d22-c74d09ab219f" xlink:to="loc_aadi_LicenseFeesIncludingPercentageOfOutstandingPaymentObligation_e38ec9af-9f01-4dae-9666-2bbe08961a16" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_DueToLicensor_0b7af7a7-cdb2-4b4e-83d1-2c6058500987" xlink:href="aadi-20230331.xsd#aadi_DueToLicensor"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CapitalizedContractCostLineItems_30c367fb-14a8-4326-9d22-c74d09ab219f" xlink:to="loc_aadi_DueToLicensor_0b7af7a7-cdb2-4b4e-83d1-2c6058500987" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_RelatedPartyTransactionBalloonPaymentInterestRatePerAnnum_4f5d58c6-4e19-4b3e-a9bf-d903867799fd" xlink:href="aadi-20230331.xsd#aadi_RelatedPartyTransactionBalloonPaymentInterestRatePerAnnum"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CapitalizedContractCostLineItems_30c367fb-14a8-4326-9d22-c74d09ab219f" xlink:to="loc_aadi_RelatedPartyTransactionBalloonPaymentInterestRatePerAnnum_4f5d58c6-4e19-4b3e-a9bf-d903867799fd" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromLicenseFeesReceived_16e3b891-698a-41eb-aed2-6097a11d4ae1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromLicenseFeesReceived"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CapitalizedContractCostLineItems_30c367fb-14a8-4326-9d22-c74d09ab219f" xlink:to="loc_us-gaap_ProceedsFromLicenseFeesReceived_16e3b891-698a-41eb-aed2-6097a11d4ae1" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_SublicenseFeesPercentage_9b62b4a3-7720-4474-b9ec-34eb3eaad022" xlink:href="aadi-20230331.xsd#aadi_SublicenseFeesPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CapitalizedContractCostLineItems_30c367fb-14a8-4326-9d22-c74d09ab219f" xlink:to="loc_aadi_SublicenseFeesPercentage_9b62b4a3-7720-4474-b9ec-34eb3eaad022" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_RightToTerminateLicenseAgreement_b9ebbefe-273e-45a7-9e95-843cc3bede1b" xlink:href="aadi-20230331.xsd#aadi_RightToTerminateLicenseAgreement"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CapitalizedContractCostLineItems_30c367fb-14a8-4326-9d22-c74d09ab219f" xlink:to="loc_aadi_RightToTerminateLicenseAgreement_b9ebbefe-273e-45a7-9e95-843cc3bede1b" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_UpfrontPaymentForLicenseAgreement_5845808b-ff07-4d2c-81bb-0e2ff33caf17" xlink:href="aadi-20230331.xsd#aadi_UpfrontPaymentForLicenseAgreement"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CapitalizedContractCostLineItems_30c367fb-14a8-4326-9d22-c74d09ab219f" xlink:to="loc_aadi_UpfrontPaymentForLicenseAgreement_5845808b-ff07-4d2c-81bb-0e2ff33caf17" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_0a7ed8f1-8f01-4fb5-93f5-140fe8b163d0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CapitalizedContractCostLineItems_30c367fb-14a8-4326-9d22-c74d09ab219f" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_0a7ed8f1-8f01-4fb5-93f5-140fe8b163d0" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_AmountOfCertainDevelopmentRegulatoryAndSalesMilestonesPaymentsEligibleToReceiveUnderLicenseAgreement_5cba26e8-8180-4c36-941e-66643fd07a8a" xlink:href="aadi-20230331.xsd#aadi_AmountOfCertainDevelopmentRegulatoryAndSalesMilestonesPaymentsEligibleToReceiveUnderLicenseAgreement"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CapitalizedContractCostLineItems_30c367fb-14a8-4326-9d22-c74d09ab219f" xlink:to="loc_aadi_AmountOfCertainDevelopmentRegulatoryAndSalesMilestonesPaymentsEligibleToReceiveUnderLicenseAgreement_5cba26e8-8180-4c36-941e-66643fd07a8a" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CapitalizedContractCostTable_5a31593e-1b74-4d76-8340-a72f144ad8d6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CapitalizedContractCostTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_CapitalizedContractCostLineItems_30c367fb-14a8-4326-9d22-c74d09ab219f" xlink:to="loc_us-gaap_CapitalizedContractCostTable_5a31593e-1b74-4d76-8340-a72f144ad8d6" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_62b1ace6-bba0-4c3d-a120-9a361e1550be" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_CapitalizedContractCostTable_5a31593e-1b74-4d76-8340-a72f144ad8d6" xlink:to="loc_us-gaap_TypeOfArrangementAxis_62b1ace6-bba0-4c3d-a120-9a361e1550be" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_62b1ace6-bba0-4c3d-a120-9a361e1550be_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_62b1ace6-bba0-4c3d-a120-9a361e1550be" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_62b1ace6-bba0-4c3d-a120-9a361e1550be_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_6f80b2c8-27b4-417a-a290-59d05962be02" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_62b1ace6-bba0-4c3d-a120-9a361e1550be" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_6f80b2c8-27b4-417a-a290-59d05962be02" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_CelgeneLicenseAgreementMember_addd674b-e979-4858-be58-e842b475afd7" xlink:href="aadi-20230331.xsd#aadi_CelgeneLicenseAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_6f80b2c8-27b4-417a-a290-59d05962be02" xlink:to="loc_aadi_CelgeneLicenseAgreementMember_addd674b-e979-4858-be58-e842b475afd7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_eaccb080-3fd0-4a6d-ba83-16c9b15faae1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_CapitalizedContractCostTable_5a31593e-1b74-4d76-8340-a72f144ad8d6" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_eaccb080-3fd0-4a6d-ba83-16c9b15faae1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_eaccb080-3fd0-4a6d-ba83-16c9b15faae1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_eaccb080-3fd0-4a6d-ba83-16c9b15faae1" xlink:to="loc_us-gaap_RelatedPartyDomain_eaccb080-3fd0-4a6d-ba83-16c9b15faae1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_4f87a7a1-efbe-4502-ade1-aa4aa0a488c3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_eaccb080-3fd0-4a6d-ba83-16c9b15faae1" xlink:to="loc_us-gaap_RelatedPartyDomain_4f87a7a1-efbe-4502-ade1-aa4aa0a488c3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_CelgeneLicenseAgreementMember_bc1599f9-d64d-47fe-baea-4d44b22b617d" xlink:href="aadi-20230331.xsd#aadi_CelgeneLicenseAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_4f87a7a1-efbe-4502-ade1-aa4aa0a488c3" xlink:to="loc_aadi_CelgeneLicenseAgreementMember_bc1599f9-d64d-47fe-baea-4d44b22b617d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_89349ed4-d868-457c-ab11-99f58a12a4c1" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_CapitalizedContractCostTable_5a31593e-1b74-4d76-8340-a72f144ad8d6" xlink:to="loc_dei_LegalEntityAxis_89349ed4-d868-457c-ab11-99f58a12a4c1" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_89349ed4-d868-457c-ab11-99f58a12a4c1_default" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_89349ed4-d868-457c-ab11-99f58a12a4c1" xlink:to="loc_dei_EntityDomain_89349ed4-d868-457c-ab11-99f58a12a4c1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_9f123699-a10b-420f-b893-520154bd50db" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_89349ed4-d868-457c-ab11-99f58a12a4c1" xlink:to="loc_dei_EntityDomain_9f123699-a10b-420f-b893-520154bd50db" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_EOCPharmaHongKongLimitedMember_e92ef5ac-4128-4a58-b0f3-d20346d570fd" xlink:href="aadi-20230331.xsd#aadi_EOCPharmaHongKongLimitedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_9f123699-a10b-420f-b893-520154bd50db" xlink:to="loc_aadi_EOCPharmaHongKongLimitedMember_e92ef5ac-4128-4a58-b0f3-d20346d570fd" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.aadi.com/role/StockholdersEquityDeficitAdditionalInformationDetail" xlink:type="simple" xlink:href="aadi-20230331.xsd#StockholdersEquityDeficitAdditionalInformationDetail"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/StockholdersEquityDeficitAdditionalInformationDetail" xlink:type="extended" id="i8b1a3c14a0d540b890388de830712e9e_StockholdersEquityDeficitAdditionalInformationDetail">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_d0020d6e-3a4d-4524-868e-f375db0131cf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_3fdfc305-cf74-49fb-a947-2f9c898ffaac" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_d0020d6e-3a4d-4524-868e-f375db0131cf" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_3fdfc305-cf74-49fb-a947-2f9c898ffaac" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockParOrStatedValuePerShare_650dc340-c4ca-4c61-a8a3-313670e36080" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockParOrStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_d0020d6e-3a4d-4524-868e-f375db0131cf" xlink:to="loc_us-gaap_PreferredStockParOrStatedValuePerShare_650dc340-c4ca-4c61-a8a3-313670e36080" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesOutstanding_6d62114e-b215-43b6-8341-81e2d614f86e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_d0020d6e-3a4d-4524-868e-f375db0131cf" xlink:to="loc_us-gaap_PreferredStockSharesOutstanding_6d62114e-b215-43b6-8341-81e2d614f86e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_83693f1a-6d0e-4b5e-8ff4-3ccedcb61aaf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_d0020d6e-3a4d-4524-868e-f375db0131cf" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_83693f1a-6d0e-4b5e-8ff4-3ccedcb61aaf" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_500849ea-c710-4210-8bd7-a3ead16c5e0a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_d0020d6e-3a4d-4524-868e-f375db0131cf" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_500849ea-c710-4210-8bd7-a3ead16c5e0a" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_cb0ef66e-3a08-4e62-ba75-c4e3d975f505" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_d0020d6e-3a4d-4524-868e-f375db0131cf" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_cb0ef66e-3a08-4e62-ba75-c4e3d975f505" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_ATMOfferingPrice_857b0b48-0f63-4845-907d-b408dc09cbae" xlink:href="aadi-20230331.xsd#aadi_ATMOfferingPrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_d0020d6e-3a4d-4524-868e-f375db0131cf" xlink:to="loc_aadi_ATMOfferingPrice_857b0b48-0f63-4845-907d-b408dc09cbae" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_ATMOfferingGrossProceedsPaidPercentage_8286f1d4-4b3b-434a-8fa7-852f204503f7" xlink:href="aadi-20230331.xsd#aadi_ATMOfferingGrossProceedsPaidPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_d0020d6e-3a4d-4524-868e-f375db0131cf" xlink:to="loc_aadi_ATMOfferingGrossProceedsPaidPercentage_8286f1d4-4b3b-434a-8fa7-852f204503f7" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_1404d7ed-61d9-4488-97e8-3e9ce24e0861" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_d0020d6e-3a4d-4524-868e-f375db0131cf" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_1404d7ed-61d9-4488-97e8-3e9ce24e0861" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_61845d6a-e31d-4521-9370-ec69fedb3f2f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockPricePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_d0020d6e-3a4d-4524-868e-f375db0131cf" xlink:to="loc_us-gaap_SaleOfStockPricePerShare_61845d6a-e31d-4521-9370-ec69fedb3f2f" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_ab051398-6889-4000-aeb3-54720c631716" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_d0020d6e-3a4d-4524-868e-f375db0131cf" xlink:to="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_ab051398-6889-4000-aeb3-54720c631716" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_11cf0dd9-b45b-4170-baad-02fe2a329cda" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_d0020d6e-3a4d-4524-868e-f375db0131cf" xlink:to="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_11cf0dd9-b45b-4170-baad-02fe2a329cda" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfStockIssuanceCosts_de904d7a-74df-4e91-bbf1-3c4333405b62" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsOfStockIssuanceCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_d0020d6e-3a4d-4524-868e-f375db0131cf" xlink:to="loc_us-gaap_PaymentsOfStockIssuanceCosts_de904d7a-74df-4e91-bbf1-3c4333405b62" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_845aaeb7-b317-4deb-b863-6bcadc38c211" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_d0020d6e-3a4d-4524-868e-f375db0131cf" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_845aaeb7-b317-4deb-b863-6bcadc38c211" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsCommonStockCash_be5facf4-b97b-4d1f-b0e0-653ae92892f9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DividendsCommonStockCash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_d0020d6e-3a4d-4524-868e-f375db0131cf" xlink:to="loc_us-gaap_DividendsCommonStockCash_be5facf4-b97b-4d1f-b0e0-653ae92892f9" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_CommonStockNumberOfVotesPerShare_6ef676da-dfc2-4f8f-8514-92d7a49d5595" xlink:href="aadi-20230331.xsd#aadi_CommonStockNumberOfVotesPerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_d0020d6e-3a4d-4524-868e-f375db0131cf" xlink:to="loc_aadi_CommonStockNumberOfVotesPerShare_6ef676da-dfc2-4f8f-8514-92d7a49d5595" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_e573dca7-e479-4ee7-a4af-0209f7afd0fc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfStockByClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_d0020d6e-3a4d-4524-868e-f375db0131cf" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_e573dca7-e479-4ee7-a4af-0209f7afd0fc" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_8739b4fe-e8ba-4dd9-abe3-fb66d83bc32b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_e573dca7-e479-4ee7-a4af-0209f7afd0fc" xlink:to="loc_us-gaap_TypeOfArrangementAxis_8739b4fe-e8ba-4dd9-abe3-fb66d83bc32b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_8739b4fe-e8ba-4dd9-abe3-fb66d83bc32b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_8739b4fe-e8ba-4dd9-abe3-fb66d83bc32b" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_8739b4fe-e8ba-4dd9-abe3-fb66d83bc32b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_df28e28e-f7fe-4f5d-bbbb-0229a17d3c05" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_8739b4fe-e8ba-4dd9-abe3-fb66d83bc32b" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_df28e28e-f7fe-4f5d-bbbb-0229a17d3c05" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_SalesAgreementMember_8bdcb749-c448-49da-8b15-f70bceef8d61" xlink:href="aadi-20230331.xsd#aadi_SalesAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_df28e28e-f7fe-4f5d-bbbb-0229a17d3c05" xlink:to="loc_aadi_SalesAgreementMember_8bdcb749-c448-49da-8b15-f70bceef8d61" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_PurchaseAgreementMember_9dc0e28f-9bf2-4961-a450-669910bc3880" xlink:href="aadi-20230331.xsd#aadi_PurchaseAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_df28e28e-f7fe-4f5d-bbbb-0229a17d3c05" xlink:to="loc_aadi_PurchaseAgreementMember_9dc0e28f-9bf2-4961-a450-669910bc3880" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_3becf40b-31f6-4886-8b21-6681c11bd6c9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_e573dca7-e479-4ee7-a4af-0209f7afd0fc" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_3becf40b-31f6-4886-8b21-6681c11bd6c9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_3becf40b-31f6-4886-8b21-6681c11bd6c9_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_3becf40b-31f6-4886-8b21-6681c11bd6c9" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_3becf40b-31f6-4886-8b21-6681c11bd6c9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_810e7825-79f7-4596-a491-fd612d9aeccd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_3becf40b-31f6-4886-8b21-6681c11bd6c9" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_810e7825-79f7-4596-a491-fd612d9aeccd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_PrivatePlacementFinancingMember_19fd8437-8758-4fdb-b8cc-ac9584e61fc7" xlink:href="aadi-20230331.xsd#aadi_PrivatePlacementFinancingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_810e7825-79f7-4596-a491-fd612d9aeccd" xlink:to="loc_aadi_PrivatePlacementFinancingMember_19fd8437-8758-4fdb-b8cc-ac9584e61fc7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_63e40b8b-eda9-4119-aa56-3b3524b4593d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_e573dca7-e479-4ee7-a4af-0209f7afd0fc" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_63e40b8b-eda9-4119-aa56-3b3524b4593d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_63e40b8b-eda9-4119-aa56-3b3524b4593d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_63e40b8b-eda9-4119-aa56-3b3524b4593d" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_63e40b8b-eda9-4119-aa56-3b3524b4593d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_c553b5a1-f818-416c-a7a3-edc17041dcbe" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_63e40b8b-eda9-4119-aa56-3b3524b4593d" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_c553b5a1-f818-416c-a7a3-edc17041dcbe" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_PreFundedWarrantMember_f7801220-773f-4a1e-9c1c-ab36fd7ca37f" xlink:href="aadi-20230331.xsd#aadi_PreFundedWarrantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_c553b5a1-f818-416c-a7a3-edc17041dcbe" xlink:to="loc_aadi_PreFundedWarrantMember_f7801220-773f-4a1e-9c1c-ab36fd7ca37f" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.aadi.com/role/ShareBasedCompensationAdditionalInformationDetail" xlink:type="simple" xlink:href="aadi-20230331.xsd#ShareBasedCompensationAdditionalInformationDetail"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/ShareBasedCompensationAdditionalInformationDetail" xlink:type="extended" id="i4b94a99ed0b34510bf0b45918e0e61b8_ShareBasedCompensationAdditionalInformationDetail">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_96e73ecb-961a-492f-884a-fc6d458248e3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_da74b9f3-1043-4e46-a33f-61892647eada" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockCapitalSharesReservedForFutureIssuance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_96e73ecb-961a-492f-884a-fc6d458248e3" xlink:to="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_da74b9f3-1043-4e46-a33f-61892647eada" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_6a5e86c9-6081-4338-acb5-bda5e709da1a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_96e73ecb-961a-492f-884a-fc6d458248e3" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_6a5e86c9-6081-4338-acb5-bda5e709da1a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_9d632dc4-4852-4b82-bf29-838e6496bb36" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_96e73ecb-961a-492f-884a-fc6d458248e3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_9d632dc4-4852-4b82-bf29-838e6496bb36" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantedInPeriodAssumedThroughMerger_5c66770a-c529-4309-a3b4-78cb510b148d" xlink:href="aadi-20230331.xsd#aadi_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantedInPeriodAssumedThroughMerger"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_96e73ecb-961a-492f-884a-fc6d458248e3" xlink:to="loc_aadi_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantedInPeriodAssumedThroughMerger_5c66770a-c529-4309-a3b4-78cb510b148d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorizedAnnualPercentage_bd9f8342-be0b-45ce-b0f0-ceb1a1f61eae" xlink:href="aadi-20230331.xsd#aadi_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorizedAnnualPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_96e73ecb-961a-492f-884a-fc6d458248e3" xlink:to="loc_aadi_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorizedAnnualPercentage_bd9f8342-be0b-45ce-b0f0-ceb1a1f61eae" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_ac1c6da6-b2d4-4df8-bbd2-582acbd25878" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_96e73ecb-961a-492f-884a-fc6d458248e3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_ac1c6da6-b2d4-4df8-bbd2-582acbd25878" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_f505d466-37da-4a45-9232-9abd81e6474a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_96e73ecb-961a-492f-884a-fc6d458248e3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_f505d466-37da-4a45-9232-9abd81e6474a" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_ec712dab-e6db-4eb1-9023-84c9aaa222ca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_96e73ecb-961a-492f-884a-fc6d458248e3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_ec712dab-e6db-4eb1-9023-84c9aaa222ca" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_7dd4a256-b05a-4392-856a-51dc4cd1d6e6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_96e73ecb-961a-492f-884a-fc6d458248e3" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_7dd4a256-b05a-4392-856a-51dc4cd1d6e6" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_a46c8db0-86fe-431a-8d38-cd02fc4fcf38" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_96e73ecb-961a-492f-884a-fc6d458248e3" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_a46c8db0-86fe-431a-8d38-cd02fc4fcf38" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_a377362c-35db-4c6a-a727-a2726963839e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_96e73ecb-961a-492f-884a-fc6d458248e3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_a377362c-35db-4c6a-a727-a2726963839e" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightOutstanding_9ebd7c0a-9a64-48de-b8fe-3a49d3ab838f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_96e73ecb-961a-492f-884a-fc6d458248e3" xlink:to="loc_us-gaap_ClassOfWarrantOrRightOutstanding_9ebd7c0a-9a64-48de-b8fe-3a49d3ab838f" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_2031b132-9ef8-40d1-8697-ca8576bf8af6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_96e73ecb-961a-492f-884a-fc6d458248e3" xlink:to="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_2031b132-9ef8-40d1-8697-ca8576bf8af6" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityNoteStockSplitConversionRatio1_415c1237-fc4c-419f-be2b-ea2ea547bbf4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityNoteStockSplitConversionRatio1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_96e73ecb-961a-492f-884a-fc6d458248e3" xlink:to="loc_us-gaap_StockholdersEquityNoteStockSplitConversionRatio1_415c1237-fc4c-419f-be2b-ea2ea547bbf4" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_24f99773-b07b-4b28-893f-58a607183a94" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_96e73ecb-961a-492f-884a-fc6d458248e3" xlink:to="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_24f99773-b07b-4b28-893f-58a607183a94" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_NumberOfClassOfWarrantsExercised_26d9892f-0fcd-4394-be53-03518770ddbd" xlink:href="aadi-20230331.xsd#aadi_NumberOfClassOfWarrantsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_96e73ecb-961a-492f-884a-fc6d458248e3" xlink:to="loc_aadi_NumberOfClassOfWarrantsExercised_26d9892f-0fcd-4394-be53-03518770ddbd" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_1dff7b80-c343-4b16-98bf-1ea54dd61687" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_96e73ecb-961a-492f-884a-fc6d458248e3" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_1dff7b80-c343-4b16-98bf-1ea54dd61687" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_100d6b85-0d7c-4d4b-8106-137ac0441a21" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_1dff7b80-c343-4b16-98bf-1ea54dd61687" xlink:to="loc_us-gaap_PlanNameAxis_100d6b85-0d7c-4d4b-8106-137ac0441a21" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_100d6b85-0d7c-4d4b-8106-137ac0441a21_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_100d6b85-0d7c-4d4b-8106-137ac0441a21" xlink:to="loc_us-gaap_PlanNameDomain_100d6b85-0d7c-4d4b-8106-137ac0441a21_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_e96ffa45-781b-48f1-88fb-473565b4ceaa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_100d6b85-0d7c-4d4b-8106-137ac0441a21" xlink:to="loc_us-gaap_PlanNameDomain_e96ffa45-781b-48f1-88fb-473565b4ceaa" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_PrivateAadiPlanMember_7da44f90-8134-4368-9c2d-82a0061eb038" xlink:href="aadi-20230331.xsd#aadi_PrivateAadiPlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_e96ffa45-781b-48f1-88fb-473565b4ceaa" xlink:to="loc_aadi_PrivateAadiPlanMember_7da44f90-8134-4368-9c2d-82a0061eb038" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_TwoThousandElevenPlanAndTwoThousandSeventeenPlanMember_f7e5a2ed-1af3-4052-9778-9bccf55bcb8a" xlink:href="aadi-20230331.xsd#aadi_TwoThousandElevenPlanAndTwoThousandSeventeenPlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_e96ffa45-781b-48f1-88fb-473565b4ceaa" xlink:to="loc_aadi_TwoThousandElevenPlanAndTwoThousandSeventeenPlanMember_f7e5a2ed-1af3-4052-9778-9bccf55bcb8a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_TwoThousandTwentyOneEquityIncentivePlanMember_c0a3e811-68b8-4e60-b11b-d3593b068f31" xlink:href="aadi-20230331.xsd#aadi_TwoThousandTwentyOneEquityIncentivePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_e96ffa45-781b-48f1-88fb-473565b4ceaa" xlink:to="loc_aadi_TwoThousandTwentyOneEquityIncentivePlanMember_c0a3e811-68b8-4e60-b11b-d3593b068f31" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_AerpioTwoThousandElevenEquityIncentivePlanMember_3886a948-b475-443b-af81-ad55b95573a6" xlink:href="aadi-20230331.xsd#aadi_AerpioTwoThousandElevenEquityIncentivePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_e96ffa45-781b-48f1-88fb-473565b4ceaa" xlink:to="loc_aadi_AerpioTwoThousandElevenEquityIncentivePlanMember_3886a948-b475-443b-af81-ad55b95573a6" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_AerpioTwoThousandSeventeenStockOptionAndIncentivePlanMember_dcc6b77e-8fed-4c87-9e41-5d70076886c9" xlink:href="aadi-20230331.xsd#aadi_AerpioTwoThousandSeventeenStockOptionAndIncentivePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_e96ffa45-781b-48f1-88fb-473565b4ceaa" xlink:to="loc_aadi_AerpioTwoThousandSeventeenStockOptionAndIncentivePlanMember_dcc6b77e-8fed-4c87-9e41-5d70076886c9" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_e008d66b-d1f0-41d1-aaca-bf33ebffd13f" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_1dff7b80-c343-4b16-98bf-1ea54dd61687" xlink:to="loc_srt_RangeAxis_e008d66b-d1f0-41d1-aaca-bf33ebffd13f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_e008d66b-d1f0-41d1-aaca-bf33ebffd13f_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_e008d66b-d1f0-41d1-aaca-bf33ebffd13f" xlink:to="loc_srt_RangeMember_e008d66b-d1f0-41d1-aaca-bf33ebffd13f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_54445328-7994-4f67-bdc5-edbd3b7082cc" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_e008d66b-d1f0-41d1-aaca-bf33ebffd13f" xlink:to="loc_srt_RangeMember_54445328-7994-4f67-bdc5-edbd3b7082cc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_99b97ac2-fca0-4a02-bfe0-fcf742f50c3e" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_54445328-7994-4f67-bdc5-edbd3b7082cc" xlink:to="loc_srt_MaximumMember_99b97ac2-fca0-4a02-bfe0-fcf742f50c3e" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.aadi.com/role/ShareBasedCompensationSummaryofRecognizedCompensationCostRelatedtoEmployeeandNonemployeeStockBasedCompensationActivityDetail" xlink:type="simple" xlink:href="aadi-20230331.xsd#ShareBasedCompensationSummaryofRecognizedCompensationCostRelatedtoEmployeeandNonemployeeStockBasedCompensationActivityDetail"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/ShareBasedCompensationSummaryofRecognizedCompensationCostRelatedtoEmployeeandNonemployeeStockBasedCompensationActivityDetail" xlink:type="extended" id="iaf7212a3279e4e06bd04d26cf295442d_ShareBasedCompensationSummaryofRecognizedCompensationCostRelatedtoEmployeeandNonemployeeStockBasedCompensationActivityDetail">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_2a71caae-129a-4850-b1cf-e8b39947651c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_b1747634-d559-4ab9-bd57-0815bb8feb04" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_2a71caae-129a-4850-b1cf-e8b39947651c" xlink:to="loc_us-gaap_ShareBasedCompensation_b1747634-d559-4ab9-bd57-0815bb8feb04" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_b6578476-069b-47a9-a24c-fb41d555999d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_2a71caae-129a-4850-b1cf-e8b39947651c" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_b6578476-069b-47a9-a24c-fb41d555999d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_a9376d12-0e23-4b55-8785-bf304b1bd67b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_b6578476-069b-47a9-a24c-fb41d555999d" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_a9376d12-0e23-4b55-8785-bf304b1bd67b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_a9376d12-0e23-4b55-8785-bf304b1bd67b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_a9376d12-0e23-4b55-8785-bf304b1bd67b" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_a9376d12-0e23-4b55-8785-bf304b1bd67b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_4d363062-73ee-486f-a9ad-3d8de7ac0071" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_a9376d12-0e23-4b55-8785-bf304b1bd67b" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_4d363062-73ee-486f-a9ad-3d8de7ac0071" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpenseMember_9d3d951d-1a3e-4c8e-8795-7fcb21e6d052" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GeneralAndAdministrativeExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_4d363062-73ee-486f-a9ad-3d8de7ac0071" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpenseMember_9d3d951d-1a3e-4c8e-8795-7fcb21e6d052" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_a84f242f-a016-4127-91f8-591d4c453801" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_4d363062-73ee-486f-a9ad-3d8de7ac0071" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_a84f242f-a016-4127-91f8-591d4c453801" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.aadi.com/role/ShareBasedCompensationStockOptionsValuationAssumptionsDetail" xlink:type="simple" xlink:href="aadi-20230331.xsd#ShareBasedCompensationStockOptionsValuationAssumptionsDetail"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/ShareBasedCompensationStockOptionsValuationAssumptionsDetail" xlink:type="extended" id="ifbff136a5dfd49d0b99eeb3cf090ce97_ShareBasedCompensationStockOptionsValuationAssumptionsDetail">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1e2c0467-7ef4-491c-9727-6ee6b4f9d8a3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_7552268b-1dda-423e-af52-15bb9c95fa6f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1e2c0467-7ef4-491c-9727-6ee6b4f9d8a3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_7552268b-1dda-423e-af52-15bb9c95fa6f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_2d9dda33-cf16-465a-b858-0ed742e6bf77" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1e2c0467-7ef4-491c-9727-6ee6b4f9d8a3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_2d9dda33-cf16-465a-b858-0ed742e6bf77" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_911b45d0-8e3f-49c1-ba7e-bc07e8f6aade" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1e2c0467-7ef4-491c-9727-6ee6b4f9d8a3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_911b45d0-8e3f-49c1-ba7e-bc07e8f6aade" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_b4fc0787-9a23-4a4b-bd8b-e6b1919fa3a3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1e2c0467-7ef4-491c-9727-6ee6b4f9d8a3" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_b4fc0787-9a23-4a4b-bd8b-e6b1919fa3a3" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_7509c497-9aba-450f-8659-87dfe8a7e7e3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1e2c0467-7ef4-491c-9727-6ee6b4f9d8a3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_7509c497-9aba-450f-8659-87dfe8a7e7e3" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_6cb539c3-7048-4778-940e-9af2e7fbb6c0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_1e2c0467-7ef4-491c-9727-6ee6b4f9d8a3" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_6cb539c3-7048-4778-940e-9af2e7fbb6c0" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_be8c1f76-bfe0-4c0b-8a5b-da4feb3b9ff4" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_6cb539c3-7048-4778-940e-9af2e7fbb6c0" xlink:to="loc_srt_RangeAxis_be8c1f76-bfe0-4c0b-8a5b-da4feb3b9ff4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_be8c1f76-bfe0-4c0b-8a5b-da4feb3b9ff4_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_be8c1f76-bfe0-4c0b-8a5b-da4feb3b9ff4" xlink:to="loc_srt_RangeMember_be8c1f76-bfe0-4c0b-8a5b-da4feb3b9ff4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_d4b0ce04-8320-48fc-a9d5-9a9228d8d4fe" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_be8c1f76-bfe0-4c0b-8a5b-da4feb3b9ff4" xlink:to="loc_srt_RangeMember_d4b0ce04-8320-48fc-a9d5-9a9228d8d4fe" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_90e1bbe5-5177-4976-8b41-1cb80d1dc14a" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_d4b0ce04-8320-48fc-a9d5-9a9228d8d4fe" xlink:to="loc_srt_MinimumMember_90e1bbe5-5177-4976-8b41-1cb80d1dc14a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_fd8cd181-753b-45bf-9c8d-c51c917d65b1" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_d4b0ce04-8320-48fc-a9d5-9a9228d8d4fe" xlink:to="loc_srt_MaximumMember_fd8cd181-753b-45bf-9c8d-c51c917d65b1" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.aadi.com/role/EmployeeStockPurchasePlanAdditionalInformationDetail" xlink:type="simple" xlink:href="aadi-20230331.xsd#EmployeeStockPurchasePlanAdditionalInformationDetail"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/EmployeeStockPurchasePlanAdditionalInformationDetail" xlink:type="extended" id="ia0688d44ba1f4e7fab94931b2ddf394f_EmployeeStockPurchasePlanAdditionalInformationDetail">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_522848cd-0188-46d0-a526-420c2a92adb4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumEmployeeSubscriptionRate_5a314cd1-4337-4b16-aca2-1f9264671aa0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumEmployeeSubscriptionRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_522848cd-0188-46d0-a526-420c2a92adb4" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumEmployeeSubscriptionRate_5a314cd1-4337-4b16-aca2-1f9264671aa0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardOfferingPeriod_792c24de-ba84-4e23-b7b0-d80d6846b828" xlink:href="aadi-20230331.xsd#aadi_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardOfferingPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_522848cd-0188-46d0-a526-420c2a92adb4" xlink:to="loc_aadi_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardOfferingPeriod_792c24de-ba84-4e23-b7b0-d80d6846b828" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent_a8782f32-83c3-4ba7-873e-e7432397ff4c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_522848cd-0188-46d0-a526-420c2a92adb4" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent_a8782f32-83c3-4ba7-873e-e7432397ff4c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_9636d646-aa89-48d7-8566-b0b1b575734c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockCapitalSharesReservedForFutureIssuance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_522848cd-0188-46d0-a526-420c2a92adb4" xlink:to="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_9636d646-aa89-48d7-8566-b0b1b575734c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_94e46bc8-def4-4ed0-9868-30226b2eb18a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_522848cd-0188-46d0-a526-420c2a92adb4" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_94e46bc8-def4-4ed0-9868-30226b2eb18a" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_NumberOfSharesReservedForIssuanceAnnualIncreasedPercentage_1402eb6f-c577-4be2-9266-90d31c2060a9" xlink:href="aadi-20230331.xsd#aadi_NumberOfSharesReservedForIssuanceAnnualIncreasedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_522848cd-0188-46d0-a526-420c2a92adb4" xlink:to="loc_aadi_NumberOfSharesReservedForIssuanceAnnualIncreasedPercentage_1402eb6f-c577-4be2-9266-90d31c2060a9" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_95f3a8c3-afe5-4513-8cb5-0b1dff4fae45" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_522848cd-0188-46d0-a526-420c2a92adb4" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_95f3a8c3-afe5-4513-8cb5-0b1dff4fae45" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_ShareBasePaymentArrangementEmployeeStockPurchasePlanLiability_396d0a89-6709-483b-9a12-b29b249df28a" xlink:href="aadi-20230331.xsd#aadi_ShareBasePaymentArrangementEmployeeStockPurchasePlanLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_522848cd-0188-46d0-a526-420c2a92adb4" xlink:to="loc_aadi_ShareBasePaymentArrangementEmployeeStockPurchasePlanLiability_396d0a89-6709-483b-9a12-b29b249df28a" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_ShareBasedCompensationArrangementByShareBasedPaymentAwardStockPlanOfferingPeriod_19e0e0ea-d935-4a21-a486-d5c3078dde41" xlink:href="aadi-20230331.xsd#aadi_ShareBasedCompensationArrangementByShareBasedPaymentAwardStockPlanOfferingPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_522848cd-0188-46d0-a526-420c2a92adb4" xlink:to="loc_aadi_ShareBasedCompensationArrangementByShareBasedPaymentAwardStockPlanOfferingPeriod_19e0e0ea-d935-4a21-a486-d5c3078dde41" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_2848c6bd-0750-4bc8-90ee-a4b224983c8b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_522848cd-0188-46d0-a526-420c2a92adb4" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_2848c6bd-0750-4bc8-90ee-a4b224983c8b" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_1c2d2291-a83f-4e43-b4d6-c7257dbd213e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_522848cd-0188-46d0-a526-420c2a92adb4" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_1c2d2291-a83f-4e43-b4d6-c7257dbd213e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_8b410040-03a1-4171-88a3-2fa541d56670" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_1c2d2291-a83f-4e43-b4d6-c7257dbd213e" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_8b410040-03a1-4171-88a3-2fa541d56670" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_8b410040-03a1-4171-88a3-2fa541d56670_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_8b410040-03a1-4171-88a3-2fa541d56670" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_8b410040-03a1-4171-88a3-2fa541d56670_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_31547251-9fa8-479e-8c2e-ab7225bf9a84" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_8b410040-03a1-4171-88a3-2fa541d56670" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_31547251-9fa8-479e-8c2e-ab7225bf9a84" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockMember_5a3e04e5-0c8c-479c-beca-a6e0b09e4eae" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_31547251-9fa8-479e-8c2e-ab7225bf9a84" xlink:to="loc_us-gaap_EmployeeStockMember_5a3e04e5-0c8c-479c-beca-a6e0b09e4eae" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_53c0f220-0b32-4137-8fae-b90e9e87b58c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_1c2d2291-a83f-4e43-b4d6-c7257dbd213e" xlink:to="loc_us-gaap_AwardTypeAxis_53c0f220-0b32-4137-8fae-b90e9e87b58c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_53c0f220-0b32-4137-8fae-b90e9e87b58c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_53c0f220-0b32-4137-8fae-b90e9e87b58c" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_53c0f220-0b32-4137-8fae-b90e9e87b58c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_28ebb53f-f515-4357-a22c-0444b8223ddf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_53c0f220-0b32-4137-8fae-b90e9e87b58c" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_28ebb53f-f515-4357-a22c-0444b8223ddf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockMember_7a1dd92b-9264-4b90-b320-eff474496ca5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_28ebb53f-f515-4357-a22c-0444b8223ddf" xlink:to="loc_us-gaap_EmployeeStockMember_7a1dd92b-9264-4b90-b320-eff474496ca5" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.aadi.com/role/EmployeeStockPurchasePlanCalculationAssumptionsDetails" xlink:type="simple" xlink:href="aadi-20230331.xsd#EmployeeStockPurchasePlanCalculationAssumptionsDetails"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/EmployeeStockPurchasePlanCalculationAssumptionsDetails" xlink:type="extended" id="if84fb80c614e489d8cc57b3b246eb613_EmployeeStockPurchasePlanCalculationAssumptionsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c562a076-05a1-4d67-a48d-10db3ce677c2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExercisePrice_97160910-b39d-4dfb-a113-76a4ea8c7e27" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c562a076-05a1-4d67-a48d-10db3ce677c2" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExercisePrice_97160910-b39d-4dfb-a113-76a4ea8c7e27" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum_3e182435-b658-424a-840b-241af746eaca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c562a076-05a1-4d67-a48d-10db3ce677c2" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum_3e182435-b658-424a-840b-241af746eaca" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum_5d51f6cb-14ff-4d70-a9b4-ad13b26e1c19" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c562a076-05a1-4d67-a48d-10db3ce677c2" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum_5d51f6cb-14ff-4d70-a9b4-ad13b26e1c19" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum_2c10abd3-945a-461c-bd6d-e62e9e14379f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c562a076-05a1-4d67-a48d-10db3ce677c2" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum_2c10abd3-945a-461c-bd6d-e62e9e14379f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum_5b062472-937a-4659-87f2-63c4c5d56fad" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c562a076-05a1-4d67-a48d-10db3ce677c2" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum_5b062472-937a-4659-87f2-63c4c5d56fad" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_d57b87bc-9e11-48a6-a58d-51edb2e1f845" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c562a076-05a1-4d67-a48d-10db3ce677c2" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_d57b87bc-9e11-48a6-a58d-51edb2e1f845" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_c6808bce-7a89-4838-971e-bf131155ee2b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c562a076-05a1-4d67-a48d-10db3ce677c2" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_c6808bce-7a89-4838-971e-bf131155ee2b" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_04e74835-2957-4991-8665-beeb1839487f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_c562a076-05a1-4d67-a48d-10db3ce677c2" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_04e74835-2957-4991-8665-beeb1839487f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_2c459009-bfda-443e-b1a3-a52a38275a38" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_04e74835-2957-4991-8665-beeb1839487f" xlink:to="loc_us-gaap_AwardTypeAxis_2c459009-bfda-443e-b1a3-a52a38275a38" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_2c459009-bfda-443e-b1a3-a52a38275a38_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_2c459009-bfda-443e-b1a3-a52a38275a38" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_2c459009-bfda-443e-b1a3-a52a38275a38_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_e4c27c42-aa55-450b-b15a-813cbe942e7d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_2c459009-bfda-443e-b1a3-a52a38275a38" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_e4c27c42-aa55-450b-b15a-813cbe942e7d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockMember_71ab578b-4fcd-470f-91a7-6557d2de2cf1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_e4c27c42-aa55-450b-b15a-813cbe942e7d" xlink:to="loc_us-gaap_EmployeeStockMember_71ab578b-4fcd-470f-91a7-6557d2de2cf1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_f0fe89d7-4035-49fc-a7d6-df8f7b863a89" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_04e74835-2957-4991-8665-beeb1839487f" xlink:to="loc_srt_RangeAxis_f0fe89d7-4035-49fc-a7d6-df8f7b863a89" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_f0fe89d7-4035-49fc-a7d6-df8f7b863a89_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_f0fe89d7-4035-49fc-a7d6-df8f7b863a89" xlink:to="loc_srt_RangeMember_f0fe89d7-4035-49fc-a7d6-df8f7b863a89_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_3e611150-3b01-4129-8cbd-2f6c73896768" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_f0fe89d7-4035-49fc-a7d6-df8f7b863a89" xlink:to="loc_srt_RangeMember_3e611150-3b01-4129-8cbd-2f6c73896768" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_d9fa5e9d-5b81-49a0-a9ff-591c3dac4af5" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_3e611150-3b01-4129-8cbd-2f6c73896768" xlink:to="loc_srt_MinimumMember_d9fa5e9d-5b81-49a0-a9ff-591c3dac4af5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_d488d2ec-ed57-4d97-9a21-feaeb5e36705" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_3e611150-3b01-4129-8cbd-2f6c73896768" xlink:to="loc_srt_MaximumMember_d488d2ec-ed57-4d97-9a21-feaeb5e36705" xlink:type="arc" order="1"/>
  </link:definitionLink>
</link:linkbase>
