<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2023 Workiva-->
<!--r:b68974ec-1081-492f-ac74-1e4565f6a55b,g:ef2aacb6-6d15-4a68-a10e-134d49e54197-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.aadi.com/role/CondensedConsolidatedBalanceSheets" xlink:type="simple" xlink:href="aadi-20230930.xsd#CondensedConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://www.aadi.com/role/CondensedConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_661c7b1b-7bef-4155-b3c2-abe60ba2aebd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_d6bab09c-8d53-44a8-a94e-08bd9798381c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_661c7b1b-7bef-4155-b3c2-abe60ba2aebd" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_d6bab09c-8d53-44a8-a94e-08bd9798381c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_DueToLicensor_75c3c802-4fc1-4b7e-b50f-400a4fb9f034" xlink:href="aadi-20230930.xsd#aadi_DueToLicensor"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_661c7b1b-7bef-4155-b3c2-abe60ba2aebd" xlink:to="loc_aadi_DueToLicensor_75c3c802-4fc1-4b7e-b50f-400a4fb9f034" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_d6db1e84-512f-4ed4-98bc-61f499cf1526" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_661c7b1b-7bef-4155-b3c2-abe60ba2aebd" xlink:to="loc_us-gaap_LiabilitiesCurrent_d6db1e84-512f-4ed4-98bc-61f499cf1526" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_afeea2e0-0c20-4ace-ac7d-c2fc6415331b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_2790e80f-8e19-4a36-96ab-8577785f0691" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_afeea2e0-0c20-4ace-ac7d-c2fc6415331b" xlink:to="loc_us-gaap_Liabilities_2790e80f-8e19-4a36-96ab-8577785f0691" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_139ba362-e7bc-43da-8aaf-7ba455cf9856" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_afeea2e0-0c20-4ace-ac7d-c2fc6415331b" xlink:to="loc_us-gaap_CommitmentsAndContingencies_139ba362-e7bc-43da-8aaf-7ba455cf9856" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_2b3ee50c-6b89-4e3f-b057-2c63ae8ec759" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_afeea2e0-0c20-4ace-ac7d-c2fc6415331b" xlink:to="loc_us-gaap_StockholdersEquity_2b3ee50c-6b89-4e3f-b057-2c63ae8ec759" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_40db9e17-de76-4957-9e4b-d3f59db40b3a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestments_50cda32c-418c-4015-a2e4-dba4faf9d53f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShortTermInvestments"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_40db9e17-de76-4957-9e4b-d3f59db40b3a" xlink:to="loc_us-gaap_ShortTermInvestments_50cda32c-418c-4015-a2e4-dba4faf9d53f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_0dfb7445-9699-4660-903f-ff56d87a918e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_40db9e17-de76-4957-9e4b-d3f59db40b3a" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_0dfb7445-9699-4660-903f-ff56d87a918e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_30d14a66-5d3d-4fbe-b506-7aba049cea7c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_40db9e17-de76-4957-9e4b-d3f59db40b3a" xlink:to="loc_us-gaap_InventoryNet_30d14a66-5d3d-4fbe-b506-7aba049cea7c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_c642a6cc-ad2f-48cf-bc67-16c9e9e61de6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_40db9e17-de76-4957-9e4b-d3f59db40b3a" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_c642a6cc-ad2f-48cf-bc67-16c9e9e61de6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_40f7a71e-9815-4042-a321-3b4570e0ffaa" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_40db9e17-de76-4957-9e4b-d3f59db40b3a" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_40f7a71e-9815-4042-a321-3b4570e0ffaa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_8f1b46ed-465f-45b1-aeed-47f38b553b53" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_f02883dd-0696-496c-8571-54e5525e87c5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_8f1b46ed-465f-45b1-aeed-47f38b553b53" xlink:to="loc_us-gaap_AssetsCurrent_f02883dd-0696-496c-8571-54e5525e87c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_f49adac5-1ab0-493e-b206-a5550181cca8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_8f1b46ed-465f-45b1-aeed-47f38b553b53" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_f49adac5-1ab0-493e-b206-a5550181cca8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_75bdb84b-7c97-4fd2-80a9-90a4e8aacb37" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_8f1b46ed-465f-45b1-aeed-47f38b553b53" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_75bdb84b-7c97-4fd2-80a9-90a4e8aacb37" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_ecb667cd-cc0c-4509-b372-879c62974bd7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_8f1b46ed-465f-45b1-aeed-47f38b553b53" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_ecb667cd-cc0c-4509-b372-879c62974bd7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_593ea987-ede8-48ce-89ea-9c87c82a7299" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_959565c1-2fa8-4d96-a6c8-f1fb72b91bf1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_593ea987-ede8-48ce-89ea-9c87c82a7299" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_959565c1-2fa8-4d96-a6c8-f1fb72b91bf1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_fe106348-fc03-4be2-aab9-e6b44e2d8bd1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_593ea987-ede8-48ce-89ea-9c87c82a7299" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_fe106348-fc03-4be2-aab9-e6b44e2d8bd1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_c981b6ca-9f28-41ee-a924-b64b134fb9e3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_593ea987-ede8-48ce-89ea-9c87c82a7299" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_c981b6ca-9f28-41ee-a924-b64b134fb9e3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_1ad76b2e-15b7-425f-b13f-ffbcb55ed920" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_593ea987-ede8-48ce-89ea-9c87c82a7299" xlink:to="loc_us-gaap_CommonStockValue_1ad76b2e-15b7-425f-b13f-ffbcb55ed920" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_080ed0b5-6f52-4ad7-ae42-8a0dbca02678" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_593ea987-ede8-48ce-89ea-9c87c82a7299" xlink:to="loc_us-gaap_PreferredStockValue_080ed0b5-6f52-4ad7-ae42-8a0dbca02678" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_88195233-3953-4846-9d09-425a97092896" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_DueToLicensorPayable_d161410c-cb5a-45e3-88c6-89c2260ab5e4" xlink:href="aadi-20230930.xsd#aadi_DueToLicensorPayable"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_88195233-3953-4846-9d09-425a97092896" xlink:to="loc_aadi_DueToLicensorPayable_d161410c-cb5a-45e3-88c6-89c2260ab5e4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_48a5a676-5a93-46a1-9a6e-37210f7dcda2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_88195233-3953-4846-9d09-425a97092896" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_48a5a676-5a93-46a1-9a6e-37210f7dcda2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_591f5153-0b47-491c-a7df-7e10c4fda3bf" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_88195233-3953-4846-9d09-425a97092896" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_591f5153-0b47-491c-a7df-7e10c4fda3bf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_3cb93368-8ebd-4edb-81a2-529899dbfc6c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_88195233-3953-4846-9d09-425a97092896" xlink:to="loc_us-gaap_AccountsPayableCurrent_3cb93368-8ebd-4edb-81a2-529899dbfc6c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aadi.com/role/CondensedConsolidatedStatementsofOperationsandComprehensiveLoss" xlink:type="simple" xlink:href="aadi-20230930.xsd#CondensedConsolidatedStatementsofOperationsandComprehensiveLoss"/>
  <link:calculationLink xlink:role="http://www.aadi.com/role/CondensedConsolidatedStatementsofOperationsandComprehensiveLoss" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_d1034329-9f0e-475c-986a-eb531e6dc972" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_a4796fea-8cb4-4729-93ad-d9e520a1a576" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpense_d1034329-9f0e-475c-986a-eb531e6dc972" xlink:to="loc_us-gaap_InvestmentIncomeInterest_a4796fea-8cb4-4729-93ad-d9e520a1a576" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_c5a3b919-d5de-4c60-a711-9daacae43a04" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestExpense"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpense_d1034329-9f0e-475c-986a-eb531e6dc972" xlink:to="loc_us-gaap_InterestExpense_c5a3b919-d5de-4c60-a711-9daacae43a04" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_9d036afa-e6b5-412c-902f-a6868458db83" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ForeignCurrencyTransactionGainLossBeforeTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpense_d1034329-9f0e-475c-986a-eb531e6dc972" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_9d036afa-e6b5-412c-902f-a6868458db83" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_34a0da93-56b7-4efd-9212-e72276958cc9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_a70753bd-4d22-47e7-a397-98a403054dc4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_34a0da93-56b7-4efd-9212-e72276958cc9" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_a70753bd-4d22-47e7-a397-98a403054dc4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_ae0f594a-5319-4ddd-89da-74ad09bb18f2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_34a0da93-56b7-4efd-9212-e72276958cc9" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_ae0f594a-5319-4ddd-89da-74ad09bb18f2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_e119dfcc-3229-473e-90aa-07d3d36495a9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_02dff036-ce20-4329-b61a-71339af34014" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_e119dfcc-3229-473e-90aa-07d3d36495a9" xlink:to="loc_us-gaap_NetIncomeLoss_02dff036-ce20-4329-b61a-71339af34014" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_a98cfa9e-e533-4552-b4d1-99ccb370c272" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_e119dfcc-3229-473e-90aa-07d3d36495a9" xlink:to="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_a98cfa9e-e533-4552-b4d1-99ccb370c272" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_b5f92a2b-a2ba-4d6d-9f6d-47fae4368975" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_1508da38-1161-44cc-8e25-53881602c607" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CostsAndExpenses"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_b5f92a2b-a2ba-4d6d-9f6d-47fae4368975" xlink:to="loc_us-gaap_CostsAndExpenses_1508da38-1161-44cc-8e25-53881602c607" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_ad2a567b-53c3-4ac9-91c3-fe4fee91f632" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_b5f92a2b-a2ba-4d6d-9f6d-47fae4368975" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_ad2a567b-53c3-4ac9-91c3-fe4fee91f632" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_88e9c2ee-6230-420f-a58b-b8be62743a9d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CostsAndExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_fff5b15b-a451-4c75-98ae-9dbb873057da" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_88e9c2ee-6230-420f-a58b-b8be62743a9d" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_fff5b15b-a451-4c75-98ae-9dbb873057da" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_30ff808e-68eb-4b19-8ba4-9aa5c8b42105" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_88e9c2ee-6230-420f-a58b-b8be62743a9d" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_30ff808e-68eb-4b19-8ba4-9aa5c8b42105" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_f4ffa027-1347-49b5-a2c8-659d7a6efc15" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_88e9c2ee-6230-420f-a58b-b8be62743a9d" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_f4ffa027-1347-49b5-a2c8-659d7a6efc15" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_7040070d-2bf0-44dd-8387-78ac40a0d2e9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_88e9c2ee-6230-420f-a58b-b8be62743a9d" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_7040070d-2bf0-44dd-8387-78ac40a0d2e9" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aadi.com/role/CondensedConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="aadi-20230930.xsd#CondensedConsolidatedStatementsofCashFlows"/>
  <link:calculationLink xlink:role="http://www.aadi.com/role/CondensedConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_7799f527-c78f-41d8-99cd-f87f963dcd18" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromWarrantExercises_f0c96970-04cf-4ab0-b86c-c680c87b7c70" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromWarrantExercises"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_7799f527-c78f-41d8-99cd-f87f963dcd18" xlink:to="loc_us-gaap_ProceedsFromWarrantExercises_f0c96970-04cf-4ab0-b86c-c680c87b7c70" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_ProceedsFromIssuanceOfCommonStockAndWarrants_5f4a85f4-09dc-4261-9abf-ab48c50878ef" xlink:href="aadi-20230930.xsd#aadi_ProceedsFromIssuanceOfCommonStockAndWarrants"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_7799f527-c78f-41d8-99cd-f87f963dcd18" xlink:to="loc_aadi_ProceedsFromIssuanceOfCommonStockAndWarrants_5f4a85f4-09dc-4261-9abf-ab48c50878ef" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_1b390a4c-40fd-4d5b-a20e-1f6e13afe0da" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_7799f527-c78f-41d8-99cd-f87f963dcd18" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_1b390a4c-40fd-4d5b-a20e-1f6e13afe0da" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockPlans_8a7db0df-807a-4efd-8b6a-d999102e768b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromStockPlans"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_7799f527-c78f-41d8-99cd-f87f963dcd18" xlink:to="loc_us-gaap_ProceedsFromStockPlans_8a7db0df-807a-4efd-8b6a-d999102e768b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfFinancingCosts_005d9e9b-a2b4-45ba-86e3-e660a39851bd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsOfFinancingCosts"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_7799f527-c78f-41d8-99cd-f87f963dcd18" xlink:to="loc_us-gaap_PaymentsOfFinancingCosts_005d9e9b-a2b4-45ba-86e3-e660a39851bd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_e473e36c-5352-4aa5-a96b-388745eea69b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_80fa937a-f5cf-446f-a8c8-eac12e20fcd4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_e473e36c-5352-4aa5-a96b-388745eea69b" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_80fa937a-f5cf-446f-a8c8-eac12e20fcd4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_eacce530-b4dc-42bb-9b95-43fd50f3639a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_e473e36c-5352-4aa5-a96b-388745eea69b" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_eacce530-b4dc-42bb-9b95-43fd50f3639a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_c491900c-857d-4e36-ab6f-68787bea3c00" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_e473e36c-5352-4aa5-a96b-388745eea69b" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_c491900c-857d-4e36-ab6f-68787bea3c00" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b180cec2-f1dd-4819-bad9-015e8ff1eca0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_cb10cb43-efc4-4fe8-8911-0cc6687652c9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b180cec2-f1dd-4819-bad9-015e8ff1eca0" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_cb10cb43-efc4-4fe8-8911-0cc6687652c9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_0ae00dc2-ee46-4ff6-b727-6d4666ff385f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b180cec2-f1dd-4819-bad9-015e8ff1eca0" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_0ae00dc2-ee46-4ff6-b727-6d4666ff385f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments_7bd75313-0155-4f29-aefa-12d62b0a4594" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_b180cec2-f1dd-4819-bad9-015e8ff1eca0" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments_7bd75313-0155-4f29-aefa-12d62b0a4594" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_eb26fa49-afdb-4e52-9e69-5b9e87cb80c8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_OperatingLeaseExpenseNonCash_484b6708-de56-4594-ae82-4a0adf6fb4bd" xlink:href="aadi-20230930.xsd#aadi_OperatingLeaseExpenseNonCash"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_eb26fa49-afdb-4e52-9e69-5b9e87cb80c8" xlink:to="loc_aadi_OperatingLeaseExpenseNonCash_484b6708-de56-4594-ae82-4a0adf6fb4bd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_5fa76bb4-2f83-4b4e-848a-b13a8649e782" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_eb26fa49-afdb-4e52-9e69-5b9e87cb80c8" xlink:to="loc_us-gaap_NetIncomeLoss_5fa76bb4-2f83-4b4e-848a-b13a8649e782" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_38813298-2d2d-4445-b03e-4fdfc966376b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_eb26fa49-afdb-4e52-9e69-5b9e87cb80c8" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_38813298-2d2d-4445-b03e-4fdfc966376b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_e3a996af-666d-4107-bbee-4895ba081b86" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AmortizationOfFinancingCostsAndDiscounts"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_eb26fa49-afdb-4e52-9e69-5b9e87cb80c8" xlink:to="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_e3a996af-666d-4107-bbee-4895ba081b86" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_5dad477d-8cbf-4363-a478-90f15ca9d7e4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentAssets"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_eb26fa49-afdb-4e52-9e69-5b9e87cb80c8" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_5dad477d-8cbf-4363-a478-90f15ca9d7e4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_ImpairmentOfAcquiredContractIntangibleAsset_b90c2a4f-0e25-48c4-b865-23873047c5d4" xlink:href="aadi-20230930.xsd#aadi_ImpairmentOfAcquiredContractIntangibleAsset"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_eb26fa49-afdb-4e52-9e69-5b9e87cb80c8" xlink:to="loc_aadi_ImpairmentOfAcquiredContractIntangibleAsset_b90c2a4f-0e25-48c4-b865-23873047c5d4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_NonCashInterestExpense_f93329ee-dea2-44c9-bfc5-09df2987c213" xlink:href="aadi-20230930.xsd#aadi_NonCashInterestExpense"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_eb26fa49-afdb-4e52-9e69-5b9e87cb80c8" xlink:to="loc_aadi_NonCashInterestExpense_f93329ee-dea2-44c9-bfc5-09df2987c213" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_d2fd48d9-d6e6-414e-a4ef-d57d44854961" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_eb26fa49-afdb-4e52-9e69-5b9e87cb80c8" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_d2fd48d9-d6e6-414e-a4ef-d57d44854961" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_ce31d1e1-b5d1-4490-aa2d-e2ffaa2ce893" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_eb26fa49-afdb-4e52-9e69-5b9e87cb80c8" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_ce31d1e1-b5d1-4490-aa2d-e2ffaa2ce893" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_a663315a-e257-4c2b-bb8f-30a43e00fd6e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_eb26fa49-afdb-4e52-9e69-5b9e87cb80c8" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_a663315a-e257-4c2b-bb8f-30a43e00fd6e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_04fd6c20-ff40-4827-b3ec-551a99d45904" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_eb26fa49-afdb-4e52-9e69-5b9e87cb80c8" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_04fd6c20-ff40-4827-b3ec-551a99d45904" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_58bf6be8-4477-4ea4-90c8-74ae5bbc5488" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInOperatingLeaseLiability"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_eb26fa49-afdb-4e52-9e69-5b9e87cb80c8" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_58bf6be8-4477-4ea4-90c8-74ae5bbc5488" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_39ba4631-0b30-46cf-85e2-382aa4300d91" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_eb26fa49-afdb-4e52-9e69-5b9e87cb80c8" xlink:to="loc_us-gaap_ShareBasedCompensation_39ba4631-0b30-46cf-85e2-382aa4300d91" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aadi.com/role/SummaryofSignificantAccountingPoliciesScheduleofCashCashEquivalentsandRestrictedCashDetails" xlink:type="simple" xlink:href="aadi-20230930.xsd#SummaryofSignificantAccountingPoliciesScheduleofCashCashEquivalentsandRestrictedCashDetails"/>
  <link:calculationLink xlink:role="http://www.aadi.com/role/SummaryofSignificantAccountingPoliciesScheduleofCashCashEquivalentsandRestrictedCashDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations_cd4e1e91-d100-47f4-ae17-e1470ca510b4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsNoncurrent_39a04d71-5648-45bf-87c7-bea4734b7441" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RestrictedCashAndCashEquivalentsNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations_cd4e1e91-d100-47f4-ae17-e1470ca510b4" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsNoncurrent_39a04d71-5648-45bf-87c7-bea4734b7441" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_7fae89e7-6d3c-4b40-8bd7-f8b0a99f7ead" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations_cd4e1e91-d100-47f4-ae17-e1470ca510b4" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_7fae89e7-6d3c-4b40-8bd7-f8b0a99f7ead" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aadi.com/role/SummaryofSignificantAccountingPoliciesScheduleofInventoryDetails" xlink:type="simple" xlink:href="aadi-20230930.xsd#SummaryofSignificantAccountingPoliciesScheduleofInventoryDetails"/>
  <link:calculationLink xlink:role="http://www.aadi.com/role/SummaryofSignificantAccountingPoliciesScheduleofInventoryDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_ad286ce7-bc90-40dc-8b24-eb5a45122527" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsAndSupplies_f463e2d9-f3c9-4a13-8046-faf2e3003883" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryRawMaterialsAndSupplies"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_ad286ce7-bc90-40dc-8b24-eb5a45122527" xlink:to="loc_us-gaap_InventoryRawMaterialsAndSupplies_f463e2d9-f3c9-4a13-8046-faf2e3003883" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcess_9c0d4cb9-52d4-425c-babe-5e20a59919bb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryWorkInProcess"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_ad286ce7-bc90-40dc-8b24-eb5a45122527" xlink:to="loc_us-gaap_InventoryWorkInProcess_9c0d4cb9-52d4-425c-babe-5e20a59919bb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoods_ae173f4c-a9bd-4dff-96b0-94cc1057b77e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryFinishedGoods"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_ad286ce7-bc90-40dc-8b24-eb5a45122527" xlink:to="loc_us-gaap_InventoryFinishedGoods_ae173f4c-a9bd-4dff-96b0-94cc1057b77e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aadi.com/role/SummaryofSignificantAccountingPoliciesPropertyandEquipmentDetails" xlink:type="simple" xlink:href="aadi-20230930.xsd#SummaryofSignificantAccountingPoliciesPropertyandEquipmentDetails"/>
  <link:calculationLink xlink:role="http://www.aadi.com/role/SummaryofSignificantAccountingPoliciesPropertyandEquipmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_4e8654c2-c124-4206-90da-a07775b23fa9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_64c82f62-b622-411e-8dac-c85603332b9b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_4e8654c2-c124-4206-90da-a07775b23fa9" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_64c82f62-b622-411e-8dac-c85603332b9b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_7f5ba639-60a1-486b-9e4a-3ebafdd3d48a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_4e8654c2-c124-4206-90da-a07775b23fa9" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_7f5ba639-60a1-486b-9e4a-3ebafdd3d48a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aadi.com/role/ShortTermInvestmentsandCashEquivalentsScheduleofShortTermInvestmentsDetails" xlink:type="simple" xlink:href="aadi-20230930.xsd#ShortTermInvestmentsandCashEquivalentsScheduleofShortTermInvestmentsDetails"/>
  <link:calculationLink xlink:role="http://www.aadi.com/role/ShortTermInvestmentsandCashEquivalentsScheduleofShortTermInvestmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_f5bd0eed-fcdb-4a0f-b1c9-3672acc1caba" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_4fb18314-9b21-45a8-9b3d-575672b0f972" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_f5bd0eed-fcdb-4a0f-b1c9-3672acc1caba" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_4fb18314-9b21-45a8-9b3d-575672b0f972" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_9c7fec22-7c50-4987-8204-65ba2da6d0dc" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_f5bd0eed-fcdb-4a0f-b1c9-3672acc1caba" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_9c7fec22-7c50-4987-8204-65ba2da6d0dc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_48b0175d-6dc6-46be-b85f-3a47158aa809" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_f5bd0eed-fcdb-4a0f-b1c9-3672acc1caba" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_48b0175d-6dc6-46be-b85f-3a47158aa809" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aadi.com/role/AccruedLiabilitiesScheduleofAccruedLiabilitiesDetail" xlink:type="simple" xlink:href="aadi-20230930.xsd#AccruedLiabilitiesScheduleofAccruedLiabilitiesDetail"/>
  <link:calculationLink xlink:role="http://www.aadi.com/role/AccruedLiabilitiesScheduleofAccruedLiabilitiesDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_0ada362e-c6e7-4f9c-926d-7260a833f99b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_AccruedClinicalCurrent_99592fa9-cc6e-4eb3-bf8a-5904ef3879d4" xlink:href="aadi-20230930.xsd#aadi_AccruedClinicalCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_0ada362e-c6e7-4f9c-926d-7260a833f99b" xlink:to="loc_aadi_AccruedClinicalCurrent_99592fa9-cc6e-4eb3-bf8a-5904ef3879d4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_AdvancedCustomerPaymentsCurrent_8390ff0a-f11e-4473-9821-60c1da1251ac" xlink:href="aadi-20230930.xsd#aadi_AdvancedCustomerPaymentsCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_0ada362e-c6e7-4f9c-926d-7260a833f99b" xlink:to="loc_aadi_AdvancedCustomerPaymentsCurrent_8390ff0a-f11e-4473-9821-60c1da1251ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_AccruedContractManufacturingCurrent_a376270f-53b2-444b-8361-b8f2b668c4ac" xlink:href="aadi-20230930.xsd#aadi_AccruedContractManufacturingCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_0ada362e-c6e7-4f9c-926d-7260a833f99b" xlink:to="loc_aadi_AccruedContractManufacturingCurrent_a376270f-53b2-444b-8361-b8f2b668c4ac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_AccruedLiabilitiesOtherSalesRelatedExpensesCurrent_7f96f3a1-6319-4d7e-ab27-17b5e6a64ca3" xlink:href="aadi-20230930.xsd#aadi_AccruedLiabilitiesOtherSalesRelatedExpensesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_0ada362e-c6e7-4f9c-926d-7260a833f99b" xlink:to="loc_aadi_AccruedLiabilitiesOtherSalesRelatedExpensesCurrent_7f96f3a1-6319-4d7e-ab27-17b5e6a64ca3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedSalariesCurrent_e10d0ebc-4954-4839-bb11-16a041a38e19" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccruedSalariesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_0ada362e-c6e7-4f9c-926d-7260a833f99b" xlink:to="loc_us-gaap_AccruedSalariesCurrent_e10d0ebc-4954-4839-bb11-16a041a38e19" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_0079bd9e-2e9b-4667-ac5e-a7d421769059" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_0ada362e-c6e7-4f9c-926d-7260a833f99b" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_0079bd9e-2e9b-4667-ac5e-a7d421769059" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedBonusesCurrent_6f50942b-eb45-4a4e-bcb9-52077df6194b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccruedBonusesCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_0ada362e-c6e7-4f9c-926d-7260a833f99b" xlink:to="loc_us-gaap_AccruedBonusesCurrent_6f50942b-eb45-4a4e-bcb9-52077df6194b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_8a88973e-ddee-4e93-bf21-420b61bcf2b2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccruedProfessionalFeesCurrent"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_0ada362e-c6e7-4f9c-926d-7260a833f99b" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrent_8a88973e-ddee-4e93-bf21-420b61bcf2b2" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aadi.com/role/OperatingLeasesScheduleofInformationRelatedtoLeasesDetail" xlink:type="simple" xlink:href="aadi-20230930.xsd#OperatingLeasesScheduleofInformationRelatedtoLeasesDetail"/>
  <link:calculationLink xlink:role="http://www.aadi.com/role/OperatingLeasesScheduleofInformationRelatedtoLeasesDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_ce3b11ba-e0ee-448d-853a-1a7fdb239f68" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_19dd3381-9e20-40c7-b7cc-23798ca16fed" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeaseLiability_ce3b11ba-e0ee-448d-853a-1a7fdb239f68" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_19dd3381-9e20-40c7-b7cc-23798ca16fed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_4eed272d-a8f1-454a-bebf-0a29407bc125" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeaseLiability_ce3b11ba-e0ee-448d-853a-1a7fdb239f68" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_4eed272d-a8f1-454a-bebf-0a29407bc125" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aadi.com/role/OperatingLeasesScheduleofFutureMinimumLeasePaymentsRequiredunderOperatingLeasesDetail" xlink:type="simple" xlink:href="aadi-20230930.xsd#OperatingLeasesScheduleofFutureMinimumLeasePaymentsRequiredunderOperatingLeasesDetail"/>
  <link:calculationLink xlink:role="http://www.aadi.com/role/OperatingLeasesScheduleofFutureMinimumLeasePaymentsRequiredunderOperatingLeasesDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_abebab3c-b97c-4fa4-a56b-13e744abdd31" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_0f75410e-1f5a-41a7-99e2-89088b01f608" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_abebab3c-b97c-4fa4-a56b-13e744abdd31" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_0f75410e-1f5a-41a7-99e2-89088b01f608" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_f23ca038-0357-4a2c-b8a7-c8063420f893" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_abebab3c-b97c-4fa4-a56b-13e744abdd31" xlink:to="loc_us-gaap_OperatingLeaseLiability_f23ca038-0357-4a2c-b8a7-c8063420f893" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.aadi.com/role/OperatingLeasesScheduleofFutureMinimumLeasePaymentsRequiredunderOperatingLeasesDetail_1" xlink:type="simple" xlink:href="aadi-20230930.xsd#OperatingLeasesScheduleofFutureMinimumLeasePaymentsRequiredunderOperatingLeasesDetail_1"/>
  <link:calculationLink xlink:role="http://www.aadi.com/role/OperatingLeasesScheduleofFutureMinimumLeasePaymentsRequiredunderOperatingLeasesDetail_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_71908788-5650-44f6-ab0e-4ded3ab5b9e8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_d7f03eae-0050-4c5d-b61c-56f8829e8364" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_71908788-5650-44f6-ab0e-4ded3ab5b9e8" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_d7f03eae-0050-4c5d-b61c-56f8829e8364" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_93bdabfc-2c97-4b0d-979e-bf3b441e4adf" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_71908788-5650-44f6-ab0e-4ded3ab5b9e8" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_93bdabfc-2c97-4b0d-979e-bf3b441e4adf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_942c2755-8363-47a3-8b19-f1956cc36d51" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_71908788-5650-44f6-ab0e-4ded3ab5b9e8" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_942c2755-8363-47a3-8b19-f1956cc36d51" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_622dfafa-da92-4d6f-ab80-de0b6aa5478d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_71908788-5650-44f6-ab0e-4ded3ab5b9e8" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_622dfafa-da92-4d6f-ab80-de0b6aa5478d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_dad73655-1853-4dfe-b32b-35ec31e4be3b" xlink:href="aadi-20230930.xsd#aadi_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_71908788-5650-44f6-ab0e-4ded3ab5b9e8" xlink:to="loc_aadi_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_dad73655-1853-4dfe-b32b-35ec31e4be3b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_0e18de49-2c41-4d6b-b795-23e25438855d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_71908788-5650-44f6-ab0e-4ded3ab5b9e8" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_0e18de49-2c41-4d6b-b795-23e25438855d" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
