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        <link:definition>0000050 - Disclosure - Stockholders' Equity (Deficit) - Additional Information (Detail)</link:definition>
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        <link:definition>0000051 - Disclosure - Stock-Based Compensation - Additional Information (Detail)</link:definition>
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        <link:definition>0000052 - Disclosure - Stock-Based Compensation - Summary of Stock Option Activity (Detail)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType id="StockBasedCompensationSummaryofRecognizedCompensationCostRelatedtoEmployeeandNonemployeeStockBasedCompensationActivityDetail" roleURI="http://www.aadi.com/role/StockBasedCompensationSummaryofRecognizedCompensationCostRelatedtoEmployeeandNonemployeeStockBasedCompensationActivityDetail">
        <link:definition>0000053 - Disclosure - Stock-Based Compensation - Summary of Recognized Compensation Cost Related to Employee and Non-employee Stock-Based Compensation Activity (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType id="StockBasedCompensationStockOptionsValuationAssumptionsDetail" roleURI="http://www.aadi.com/role/StockBasedCompensationStockOptionsValuationAssumptionsDetail">
        <link:definition>0000054 - Disclosure - Stock-Based Compensation - Stock Options Valuation Assumptions (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType id="EmployeeStockPurchasePlanAdditionalInformationDetail" roleURI="http://www.aadi.com/role/EmployeeStockPurchasePlanAdditionalInformationDetail">
        <link:definition>0000055 - Disclosure - Employee Stock Purchase Plan - Additional Information (Detail)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType id="IncomeTaxesAdditionalInformationDetail" roleURI="http://www.aadi.com/role/IncomeTaxesAdditionalInformationDetail">
        <link:definition>0000056 - Disclosure - Income Taxes - Additional Information (Detail)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CommitmentsandContingenciesDetails" roleURI="http://www.aadi.com/role/CommitmentsandContingenciesDetails">
        <link:definition>0000057 - Disclosure - Commitments and Contingencies (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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  <xs:element id="aadi_LiabilitiesLesseeAbstract" abstract="true" name="LiabilitiesLesseeAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="aadi_StockIssuanceCostsIncurredIncludedInAccountsPayable" abstract="false" name="StockIssuanceCostsIncurredIncludedInAccountsPayable" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aadi_PrivatePlacementFinancingMember" abstract="true" name="PrivatePlacementFinancingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aadi_FiniteLivedIntangibleAssetsImpairedAccumulatedImpairmentLoss" abstract="false" name="FiniteLivedIntangibleAssetsImpairedAccumulatedImpairmentLoss" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aadi_PurchaseAgreementMember" abstract="true" name="PurchaseAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aadi_CommonStockNumberOfVotesPerShare" abstract="false" name="CommonStockNumberOfVotesPerShare" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="aadi_ConvertiblePreferredStockSharesIssuedUponConversionPercentage" abstract="false" name="ConvertiblePreferredStockSharesIssuedUponConversionPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="aadi_ClassOfWarrantOrRightNoticePeriod" abstract="false" name="ClassOfWarrantOrRightNoticePeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="aadi_SummaryOfSignificantAccountingPoliciesLineItems" abstract="true" name="SummaryOfSignificantAccountingPoliciesLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="aadi_PreFundedWarrantMember" abstract="true" name="PreFundedWarrantMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aadi_AssetsLesseeAbstract" abstract="true" name="AssetsLesseeAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="aadi_MaximumAggregateOfferingPrices" abstract="false" name="MaximumAggregateOfferingPrices" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aadi_AnniversaryPeriodOfClosingOfMergerAgreement" abstract="false" name="AnniversaryPeriodOfClosingOfMergerAgreement" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="aadi_AdvancedCustomerPaymentsCurrent" abstract="false" name="AdvancedCustomerPaymentsCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aadi_UpfrontPaymentForLicenseAgreement" abstract="false" name="UpfrontPaymentForLicenseAgreement" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aadi_DisclosureOfShareBasedCompensationArrangementsByShareBasedPaymentAwardAbstract" abstract="true" name="DisclosureOfShareBasedCompensationArrangementsByShareBasedPaymentAwardAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
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  <xs:element id="aadi_AccruedClinicalAndContractManufacturingExpense" abstract="false" name="AccruedClinicalAndContractManufacturingExpense" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aadi_OrganizationConsolidationAndPresentationsOfFinancialStatementsTable" abstract="true" name="OrganizationConsolidationAndPresentationsOfFinancialStatementsTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="aadi_CumulativeDividendsPaidOnSeriesAPreferredStock" abstract="false" name="CumulativeDividendsPaidOnSeriesAPreferredStock" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aadi_OutstandingOwnershipPercentageOnCommonStock" abstract="false" name="OutstandingOwnershipPercentageOnCommonStock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="aadi_PaymentsRelatedToMilestone" abstract="false" name="PaymentsRelatedToMilestone" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
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  <xs:element id="aadi_IssuanceOfCommonStockUponMerger" abstract="false" name="IssuanceOfCommonStockUponMerger" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aadi_CelgeneLicenseAgreementMember" abstract="true" name="CelgeneLicenseAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aadi_AccruedLiabilitiesOtherSalesRelatedExpensesCurrent" abstract="false" name="AccruedLiabilitiesOtherSalesRelatedExpensesCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="aadi_ConvertibleNotesInterestRateForRemainingSixthMonthsTermUntilMaturityAtTwelveMonths" abstract="false" name="ConvertibleNotesInterestRateForRemainingSixthMonthsTermUntilMaturityAtTwelveMonths" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="aadi_PeriodAfterWhichDebtInstrumentForgiven" abstract="false" name="PeriodAfterWhichDebtInstrumentForgiven" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="aadi_AerpioTwoThousandElevenEquityIncentivePlanMember" abstract="true" name="AerpioTwoThousandElevenEquityIncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aadi_MergerAgreementMember" abstract="true" name="MergerAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aadi_RightToTerminateLicenseAgreement" abstract="false" name="RightToTerminateLicenseAgreement" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="aadi_PrivateAadiPlanMember" abstract="true" name="PrivateAadiPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aadi_ShareholdersImmediatelyPriorToClosingOfMergerMember" abstract="true" name="ShareholdersImmediatelyPriorToClosingOfMergerMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="aadi_AccruedContractManufacturingCurrent" abstract="false" name="AccruedContractManufacturingCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
