<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2023 Workiva-->
<!--r:a3fe34af-b62f-4165-a6c8-229ae8f09698,g:02df9ea5-48b7-4f7a-9ce6-f68e25f2a554-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.aadi.com/role/CondensedConsolidatedStatementsofOperations" xlink:type="simple" xlink:href="aadi-20230630.xsd#CondensedConsolidatedStatementsofOperations"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/CondensedConsolidatedStatementsofOperations" xlink:type="extended" id="i09bbbc88095142e7a3901a079619e495_CondensedConsolidatedStatementsofOperations">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_5aed8881-ab0a-42ca-801c-de45457ad9ce" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_9e518723-0312-4866-9d70-d6471774fd06" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_5aed8881-ab0a-42ca-801c-de45457ad9ce" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_9e518723-0312-4866-9d70-d6471774fd06" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpensesAbstract_75165e88-3c26-46d6-b9cb-9a1c357ac676" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingExpensesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_5aed8881-ab0a-42ca-801c-de45457ad9ce" xlink:to="loc_us-gaap_OperatingExpensesAbstract_75165e88-3c26-46d6-b9cb-9a1c357ac676" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_3d6f0b65-99c0-4215-8d3a-594aaf7435e5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_75165e88-3c26-46d6-b9cb-9a1c357ac676" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_3d6f0b65-99c0-4215-8d3a-594aaf7435e5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_0b643ba4-33f2-47da-902a-ea55ee782e2a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_75165e88-3c26-46d6-b9cb-9a1c357ac676" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_0b643ba4-33f2-47da-902a-ea55ee782e2a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_17ededd3-e47d-4104-8cf4-6805c07065d9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_75165e88-3c26-46d6-b9cb-9a1c357ac676" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_17ededd3-e47d-4104-8cf4-6805c07065d9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_ca432cc9-a8d8-47cf-901a-ca6614b1a49c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_75165e88-3c26-46d6-b9cb-9a1c357ac676" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsExcludingGoodwill_ca432cc9-a8d8-47cf-901a-ca6614b1a49c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_c96f5d6b-6934-4624-8d93-49f7a60c1963" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CostsAndExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_75165e88-3c26-46d6-b9cb-9a1c357ac676" xlink:to="loc_us-gaap_CostsAndExpenses_c96f5d6b-6934-4624-8d93-49f7a60c1963" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_8ef41a35-1805-488a-8e98-40d4a186b6de" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_5aed8881-ab0a-42ca-801c-de45457ad9ce" xlink:to="loc_us-gaap_OperatingIncomeLoss_8ef41a35-1805-488a-8e98-40d4a186b6de" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_eb5c59e1-e419-45c4-ae18-d4d6f7e0f62b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherNonoperatingIncomeExpenseAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_5aed8881-ab0a-42ca-801c-de45457ad9ce" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_eb5c59e1-e419-45c4-ae18-d4d6f7e0f62b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_2c5eed7b-b434-4349-86cd-02ce4061b2b5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ForeignCurrencyTransactionGainLossBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_eb5c59e1-e419-45c4-ae18-d4d6f7e0f62b" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_2c5eed7b-b434-4349-86cd-02ce4061b2b5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_6f0286b1-be70-43e4-bef3-ba173838ccf6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_eb5c59e1-e419-45c4-ae18-d4d6f7e0f62b" xlink:to="loc_us-gaap_InvestmentIncomeInterest_6f0286b1-be70-43e4-bef3-ba173838ccf6" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_f462fceb-57a8-4de4-bcfb-d5ed9aa0f5ff" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_eb5c59e1-e419-45c4-ae18-d4d6f7e0f62b" xlink:to="loc_us-gaap_InterestExpense_f462fceb-57a8-4de4-bcfb-d5ed9aa0f5ff" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_29ff4eaa-1170-471e-b287-7ac18cf1803d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_eb5c59e1-e419-45c4-ae18-d4d6f7e0f62b" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_29ff4eaa-1170-471e-b287-7ac18cf1803d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_e428bb80-2018-429b-b01b-df9717d3fb01" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_eb5c59e1-e419-45c4-ae18-d4d6f7e0f62b" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_e428bb80-2018-429b-b01b-df9717d3fb01" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_cd38e15e-cc78-4a87-8981-fe88bdea210f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_5aed8881-ab0a-42ca-801c-de45457ad9ce" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_cd38e15e-cc78-4a87-8981-fe88bdea210f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_29970e1a-ad5a-4b0f-b4ac-e35d7d3c31f0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_5aed8881-ab0a-42ca-801c-de45457ad9ce" xlink:to="loc_us-gaap_NetIncomeLoss_29970e1a-ad5a-4b0f-b4ac-e35d7d3c31f0" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_0cfea3fb-4905-4e28-b75b-425f1a3f6045" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_5aed8881-ab0a-42ca-801c-de45457ad9ce" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_0cfea3fb-4905-4e28-b75b-425f1a3f6045" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_283888e6-b06b-47c1-b5da-1f206afdb923" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_0cfea3fb-4905-4e28-b75b-425f1a3f6045" xlink:to="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_283888e6-b06b-47c1-b5da-1f206afdb923" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_218fe0f2-dcdb-481c-9267-a3e1b2c36678" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_5aed8881-ab0a-42ca-801c-de45457ad9ce" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTax_218fe0f2-dcdb-481c-9267-a3e1b2c36678" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_4def9441-182f-4c97-a344-565fb8b00ed0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_5aed8881-ab0a-42ca-801c-de45457ad9ce" xlink:to="loc_us-gaap_EarningsPerShareBasic_4def9441-182f-4c97-a344-565fb8b00ed0" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_e2ef2365-db28-472d-a37c-d70a7e5e4969" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_5aed8881-ab0a-42ca-801c-de45457ad9ce" xlink:to="loc_us-gaap_EarningsPerShareDiluted_e2ef2365-db28-472d-a37c-d70a7e5e4969" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_8d803d4b-c1ad-4415-b7cc-fcb3b1529983" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_5aed8881-ab0a-42ca-801c-de45457ad9ce" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_8d803d4b-c1ad-4415-b7cc-fcb3b1529983" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_dbc3e909-627d-4afe-9fce-acb0e0fc186d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_5aed8881-ab0a-42ca-801c-de45457ad9ce" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_dbc3e909-627d-4afe-9fce-acb0e0fc186d" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_446d28ec-7877-43de-a577-7b41faac751f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_5aed8881-ab0a-42ca-801c-de45457ad9ce" xlink:to="loc_us-gaap_StatementTable_446d28ec-7877-43de-a577-7b41faac751f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_b68a904b-b968-4ac5-a764-67e717831150" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_446d28ec-7877-43de-a577-7b41faac751f" xlink:to="loc_srt_ProductOrServiceAxis_b68a904b-b968-4ac5-a764-67e717831150" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_b68a904b-b968-4ac5-a764-67e717831150_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_b68a904b-b968-4ac5-a764-67e717831150" xlink:to="loc_srt_ProductsAndServicesDomain_b68a904b-b968-4ac5-a764-67e717831150_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_57b61a6a-d585-4157-9168-acbd4532bc65" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_b68a904b-b968-4ac5-a764-67e717831150" xlink:to="loc_srt_ProductsAndServicesDomain_57b61a6a-d585-4157-9168-acbd4532bc65" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductMember_3a9e354a-149b-4ac3-b689-d48a657be0a9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProductMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_57b61a6a-d585-4157-9168-acbd4532bc65" xlink:to="loc_us-gaap_ProductMember_3a9e354a-149b-4ac3-b689-d48a657be0a9" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.aadi.com/role/CondensedConsolidatedStatementsofStockholdersEquity" xlink:type="simple" xlink:href="aadi-20230630.xsd#CondensedConsolidatedStatementsofStockholdersEquity"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/CondensedConsolidatedStatementsofStockholdersEquity" xlink:type="extended" id="i6660c57ba7cc4ddc81863f87c83af7d1_CondensedConsolidatedStatementsofStockholdersEquity">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_f339bc97-aee3-4c23-92b6-aed41b364610" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_18968c2c-e514-4d9e-bb99-354485d775e8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_f339bc97-aee3-4c23-92b6-aed41b364610" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_18968c2c-e514-4d9e-bb99-354485d775e8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_41b58b01-f8b7-44e1-92d0-aab1fbef62e0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_18968c2c-e514-4d9e-bb99-354485d775e8" xlink:to="loc_us-gaap_SharesOutstanding_41b58b01-f8b7-44e1-92d0-aab1fbef62e0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_bca0775b-9dc8-4109-b318-e79c1e24d54c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_18968c2c-e514-4d9e-bb99-354485d775e8" xlink:to="loc_us-gaap_StockholdersEquity_bca0775b-9dc8-4109-b318-e79c1e24d54c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_a0f4f6c8-762b-40cd-8d53-773448a587a7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_18968c2c-e514-4d9e-bb99-354485d775e8" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_a0f4f6c8-762b-40cd-8d53-773448a587a7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_StockIssuedDuringPeriodSharesWarrantExercised_122d8f83-d0ef-487e-9738-a997179b08c9" xlink:href="aadi-20230630.xsd#aadi_StockIssuedDuringPeriodSharesWarrantExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_18968c2c-e514-4d9e-bb99-354485d775e8" xlink:to="loc_aadi_StockIssuedDuringPeriodSharesWarrantExercised_122d8f83-d0ef-487e-9738-a997179b08c9" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_StockIssuedDuringPeriodValueWarrantExercised_ca170a05-8f55-49a5-ba6c-f4f5253b7b49" xlink:href="aadi-20230630.xsd#aadi_StockIssuedDuringPeriodValueWarrantExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_18968c2c-e514-4d9e-bb99-354485d775e8" xlink:to="loc_aadi_StockIssuedDuringPeriodValueWarrantExercised_ca170a05-8f55-49a5-ba6c-f4f5253b7b49" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_9cc7d913-f605-4429-b29f-3ceb09666f21" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_18968c2c-e514-4d9e-bb99-354485d775e8" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_9cc7d913-f605-4429-b29f-3ceb09666f21" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_1aafd6ce-1bf2-457c-9e04-a224cd64408a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_18968c2c-e514-4d9e-bb99-354485d775e8" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_1aafd6ce-1bf2-457c-9e04-a224cd64408a" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_63a0b27f-69b1-445a-a494-657ed6a74819" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_18968c2c-e514-4d9e-bb99-354485d775e8" xlink:to="loc_us-gaap_OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent_63a0b27f-69b1-445a-a494-657ed6a74819" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_cbffad01-9e4b-4910-a578-1f5c5df660ce" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_18968c2c-e514-4d9e-bb99-354485d775e8" xlink:to="loc_us-gaap_NetIncomeLoss_cbffad01-9e4b-4910-a578-1f5c5df660ce" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_2fac4829-028c-454c-bfab-cd2ef2046a7f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_3a8acc35-b0de-405a-88e4-b27dccb1b283" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_13894470-bae8-47c8-b1b6-2278832cbbfe" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_f339bc97-aee3-4c23-92b6-aed41b364610" xlink:to="loc_us-gaap_StatementTable_13894470-bae8-47c8-b1b6-2278832cbbfe" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_234972b0-5aff-4ed6-a4d5-f5aac2d4b15f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_13894470-bae8-47c8-b1b6-2278832cbbfe" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_234972b0-5aff-4ed6-a4d5-f5aac2d4b15f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_234972b0-5aff-4ed6-a4d5-f5aac2d4b15f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_234972b0-5aff-4ed6-a4d5-f5aac2d4b15f" xlink:to="loc_us-gaap_EquityComponentDomain_234972b0-5aff-4ed6-a4d5-f5aac2d4b15f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_790e1833-c148-422a-bd5c-1f366d065dcf" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_234972b0-5aff-4ed6-a4d5-f5aac2d4b15f" xlink:to="loc_us-gaap_EquityComponentDomain_790e1833-c148-422a-bd5c-1f366d065dcf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_a53e3d8d-f10d-404f-8711-249415862b34" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_790e1833-c148-422a-bd5c-1f366d065dcf" xlink:to="loc_us-gaap_CommonStockMember_a53e3d8d-f10d-404f-8711-249415862b34" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_fe9bd16c-6c87-448d-b646-bd0eb73d5a50" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_790e1833-c148-422a-bd5c-1f366d065dcf" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_fe9bd16c-6c87-448d-b646-bd0eb73d5a50" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_03e47da1-278f-4a8a-b702-9f20863ab4d0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_790e1833-c148-422a-bd5c-1f366d065dcf" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_03e47da1-278f-4a8a-b702-9f20863ab4d0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_ef89007a-c158-4b05-ba77-693cc505d0cf" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_790e1833-c148-422a-bd5c-1f366d065dcf" xlink:to="loc_us-gaap_RetainedEarningsMember_ef89007a-c158-4b05-ba77-693cc505d0cf" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.aadi.com/role/NatureofOrganizationandOperationsAdditionalInformationDetail" xlink:type="simple" xlink:href="aadi-20230630.xsd#NatureofOrganizationandOperationsAdditionalInformationDetail"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/NatureofOrganizationandOperationsAdditionalInformationDetail" xlink:type="extended" id="ia3ea44a4625f475c84d0429d441e6fd1_NatureofOrganizationandOperationsAdditionalInformationDetail">
    <link:loc xlink:type="locator" xlink:label="loc_aadi_OrganizationConsolidationAndPresentationsOfFinancialStatementsLineItems_c17550bd-8440-44ea-b12f-f64f46a877af" xlink:href="aadi-20230630.xsd#aadi_OrganizationConsolidationAndPresentationsOfFinancialStatementsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_73224f9c-e517-4905-9f84-722ab2f763ec" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_OrganizationConsolidationAndPresentationsOfFinancialStatementsLineItems_c17550bd-8440-44ea-b12f-f64f46a877af" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_73224f9c-e517-4905-9f84-722ab2f763ec" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_0b046092-9ea9-448c-85d9-def4440b5559" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_OrganizationConsolidationAndPresentationsOfFinancialStatementsLineItems_c17550bd-8440-44ea-b12f-f64f46a877af" xlink:to="loc_us-gaap_NetIncomeLoss_0b046092-9ea9-448c-85d9-def4440b5559" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsAndShortTermInvestments_738415e8-8233-40a4-9f3f-d0f663c385db" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashCashEquivalentsAndShortTermInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_OrganizationConsolidationAndPresentationsOfFinancialStatementsLineItems_c17550bd-8440-44ea-b12f-f64f46a877af" xlink:to="loc_us-gaap_CashCashEquivalentsAndShortTermInvestments_738415e8-8233-40a4-9f3f-d0f663c385db" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_MaximumAggregateOfferingPrices_4e43832e-8f8d-4f07-97f8-c74bca5ed9e7" xlink:href="aadi-20230630.xsd#aadi_MaximumAggregateOfferingPrices"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_OrganizationConsolidationAndPresentationsOfFinancialStatementsLineItems_c17550bd-8440-44ea-b12f-f64f46a877af" xlink:to="loc_aadi_MaximumAggregateOfferingPrices_4e43832e-8f8d-4f07-97f8-c74bca5ed9e7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_70239f54-8501-4dce-8b99-80ee547ac88c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_OrganizationConsolidationAndPresentationsOfFinancialStatementsLineItems_c17550bd-8440-44ea-b12f-f64f46a877af" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_70239f54-8501-4dce-8b99-80ee547ac88c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_OrganizationConsolidationAndPresentationsOfFinancialStatementsTable_0b4a18df-c580-4f3a-b070-b26e042045af" xlink:href="aadi-20230630.xsd#aadi_OrganizationConsolidationAndPresentationsOfFinancialStatementsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_aadi_OrganizationConsolidationAndPresentationsOfFinancialStatementsLineItems_c17550bd-8440-44ea-b12f-f64f46a877af" xlink:to="loc_aadi_OrganizationConsolidationAndPresentationsOfFinancialStatementsTable_0b4a18df-c580-4f3a-b070-b26e042045af" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_112022b2-a0e1-4435-b210-8447f4e4545a" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_aadi_OrganizationConsolidationAndPresentationsOfFinancialStatementsTable_0b4a18df-c580-4f3a-b070-b26e042045af" xlink:to="loc_srt_CounterpartyNameAxis_112022b2-a0e1-4435-b210-8447f4e4545a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_112022b2-a0e1-4435-b210-8447f4e4545a_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_112022b2-a0e1-4435-b210-8447f4e4545a" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_112022b2-a0e1-4435-b210-8447f4e4545a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_3172a9df-f1a4-45a6-af12-ab9dd8577341" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_112022b2-a0e1-4435-b210-8447f4e4545a" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_3172a9df-f1a4-45a6-af12-ab9dd8577341" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_CowenAndCompanyLLCMember_c87c71b0-f2f7-494c-9bf9-7d44bd37d683" xlink:href="aadi-20230630.xsd#aadi_CowenAndCompanyLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_3172a9df-f1a4-45a6-af12-ab9dd8577341" xlink:to="loc_aadi_CowenAndCompanyLLCMember_c87c71b0-f2f7-494c-9bf9-7d44bd37d683" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_090153d7-55bc-4db8-bf2a-7ef6c972cc74" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_aadi_OrganizationConsolidationAndPresentationsOfFinancialStatementsTable_0b4a18df-c580-4f3a-b070-b26e042045af" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_090153d7-55bc-4db8-bf2a-7ef6c972cc74" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_090153d7-55bc-4db8-bf2a-7ef6c972cc74_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_090153d7-55bc-4db8-bf2a-7ef6c972cc74" xlink:to="loc_us-gaap_EquityComponentDomain_090153d7-55bc-4db8-bf2a-7ef6c972cc74_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_6a3f8db7-a385-49e7-ba5c-270d5a2c02ab" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_090153d7-55bc-4db8-bf2a-7ef6c972cc74" xlink:to="loc_us-gaap_EquityComponentDomain_6a3f8db7-a385-49e7-ba5c-270d5a2c02ab" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_37ce99fc-e789-4a3f-85d7-0326539a6dd2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_6a3f8db7-a385-49e7-ba5c-270d5a2c02ab" xlink:to="loc_us-gaap_CommonStockMember_37ce99fc-e789-4a3f-85d7-0326539a6dd2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_2cc723e7-8e20-4fe4-8bcc-eb7aa58ab18c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_aadi_OrganizationConsolidationAndPresentationsOfFinancialStatementsTable_0b4a18df-c580-4f3a-b070-b26e042045af" xlink:to="loc_us-gaap_TypeOfArrangementAxis_2cc723e7-8e20-4fe4-8bcc-eb7aa58ab18c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_2cc723e7-8e20-4fe4-8bcc-eb7aa58ab18c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_2cc723e7-8e20-4fe4-8bcc-eb7aa58ab18c" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_2cc723e7-8e20-4fe4-8bcc-eb7aa58ab18c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_0f442f26-c229-4da8-a6f7-5462d552fef1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_2cc723e7-8e20-4fe4-8bcc-eb7aa58ab18c" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_0f442f26-c229-4da8-a6f7-5462d552fef1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_SalesAgreementMember_a7f123df-da17-41a7-bce7-e14ba7653ca4" xlink:href="aadi-20230630.xsd#aadi_SalesAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_0f442f26-c229-4da8-a6f7-5462d552fef1" xlink:to="loc_aadi_SalesAgreementMember_a7f123df-da17-41a7-bce7-e14ba7653ca4" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.aadi.com/role/SummaryofSignificantAccountingPoliciesAdditionalInformationDetail" xlink:type="simple" xlink:href="aadi-20230630.xsd#SummaryofSignificantAccountingPoliciesAdditionalInformationDetail"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/SummaryofSignificantAccountingPoliciesAdditionalInformationDetail" xlink:type="extended" id="i4f69199f5e614da4b72d93f3b5f20a60_SummaryofSignificantAccountingPoliciesAdditionalInformationDetail">
    <link:loc xlink:type="locator" xlink:label="loc_aadi_SummaryOfSignificantAccountingPoliciesLineItems_5fe3b43c-913b-4e80-8748-ff14b051a709" xlink:href="aadi-20230630.xsd#aadi_SummaryOfSignificantAccountingPoliciesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfOperatingSegments_a2c39170-2ae9-4393-951d-79583444d56c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NumberOfOperatingSegments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesLineItems_5fe3b43c-913b-4e80-8748-ff14b051a709" xlink:to="loc_us-gaap_NumberOfOperatingSegments_a2c39170-2ae9-4393-951d-79583444d56c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_f7456860-657e-4b37-8eef-76ed0788689b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskPercentage1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesLineItems_5fe3b43c-913b-4e80-8748-ff14b051a709" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_f7456860-657e-4b37-8eef-76ed0788689b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_0f0429ab-011c-401a-a079-1ebb1f788bc8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesLineItems_5fe3b43c-913b-4e80-8748-ff14b051a709" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_0f0429ab-011c-401a-a079-1ebb1f788bc8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsPremiumsAndOtherReceivables_7b3a6ae6-f3a2-4ebb-95e0-6f9e6aaa0853" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AllowanceForDoubtfulAccountsPremiumsAndOtherReceivables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesLineItems_5fe3b43c-913b-4e80-8748-ff14b051a709" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsPremiumsAndOtherReceivables_7b3a6ae6-f3a2-4ebb-95e0-6f9e6aaa0853" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivable_80432c02-e0ac-45c3-8d88-b5842d41f136" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesLineItems_5fe3b43c-913b-4e80-8748-ff14b051a709" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivable_80432c02-e0ac-45c3-8d88-b5842d41f136" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableWriteOffs_c1997925-ade6-4601-889d-f774ce393fbe" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableWriteOffs"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesLineItems_5fe3b43c-913b-4e80-8748-ff14b051a709" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableWriteOffs_c1997925-ade6-4601-889d-f774ce393fbe" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_a4a47055-1e66-42d6-a044-19165b863ae7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesLineItems_5fe3b43c-913b-4e80-8748-ff14b051a709" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_a4a47055-1e66-42d6-a044-19165b863ae7" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesChargedToCostAndExpense_acfb2aa0-8b99-4bcc-a6d6-8ff8f04a04bd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ValuationAllowancesAndReservesChargedToCostAndExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesLineItems_5fe3b43c-913b-4e80-8748-ff14b051a709" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesChargedToCostAndExpense_acfb2aa0-8b99-4bcc-a6d6-8ff8f04a04bd" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_8d7e91be-613c-49c5-be49-a1c295fe58a3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesLineItems_5fe3b43c-913b-4e80-8748-ff14b051a709" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_8d7e91be-613c-49c5-be49-a1c295fe58a3" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_ShareBasedCompensationArrangementByShareBasedPaymentAwardStockPlanOfferingPeriod_db108681-b6b2-4133-a6da-eba945dd1228" xlink:href="aadi-20230630.xsd#aadi_ShareBasedCompensationArrangementByShareBasedPaymentAwardStockPlanOfferingPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesLineItems_5fe3b43c-913b-4e80-8748-ff14b051a709" xlink:to="loc_aadi_ShareBasedCompensationArrangementByShareBasedPaymentAwardStockPlanOfferingPeriod_db108681-b6b2-4133-a6da-eba945dd1228" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_cba868b3-506e-4da3-bcd9-24f059aaeffd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesLineItems_5fe3b43c-913b-4e80-8748-ff14b051a709" xlink:to="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_cba868b3-506e-4da3-bcd9-24f059aaeffd" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_a441cdc2-e23d-4225-9999-f94c38a20c90" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesLineItems_5fe3b43c-913b-4e80-8748-ff14b051a709" xlink:to="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_a441cdc2-e23d-4225-9999-f94c38a20c90" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_SummaryOfSignificantAccountingPoliciesTable_1d5d613c-d4e2-4deb-93c2-225f7bbe9c21" xlink:href="aadi-20230630.xsd#aadi_SummaryOfSignificantAccountingPoliciesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesLineItems_5fe3b43c-913b-4e80-8748-ff14b051a709" xlink:to="loc_aadi_SummaryOfSignificantAccountingPoliciesTable_1d5d613c-d4e2-4deb-93c2-225f7bbe9c21" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MajorCustomersAxis_df0a96db-99e5-45a5-a2fa-71630ae6e9e9" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MajorCustomersAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesTable_1d5d613c-d4e2-4deb-93c2-225f7bbe9c21" xlink:to="loc_srt_MajorCustomersAxis_df0a96db-99e5-45a5-a2fa-71630ae6e9e9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NameOfMajorCustomerDomain_df0a96db-99e5-45a5-a2fa-71630ae6e9e9_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_NameOfMajorCustomerDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_MajorCustomersAxis_df0a96db-99e5-45a5-a2fa-71630ae6e9e9" xlink:to="loc_srt_NameOfMajorCustomerDomain_df0a96db-99e5-45a5-a2fa-71630ae6e9e9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NameOfMajorCustomerDomain_fcc56bb3-05e8-4eda-85c6-0d4e973d0308" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_NameOfMajorCustomerDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_MajorCustomersAxis_df0a96db-99e5-45a5-a2fa-71630ae6e9e9" xlink:to="loc_srt_NameOfMajorCustomerDomain_fcc56bb3-05e8-4eda-85c6-0d4e973d0308" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_CompanyOneMember_d9420d4c-89d2-44d5-994b-8a15cf75e713" xlink:href="aadi-20230630.xsd#aadi_CompanyOneMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_fcc56bb3-05e8-4eda-85c6-0d4e973d0308" xlink:to="loc_aadi_CompanyOneMember_d9420d4c-89d2-44d5-994b-8a15cf75e713" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_CompanyTwoMember_58a53c51-ab03-48d4-b092-0ecbc504316c" xlink:href="aadi-20230630.xsd#aadi_CompanyTwoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_fcc56bb3-05e8-4eda-85c6-0d4e973d0308" xlink:to="loc_aadi_CompanyTwoMember_58a53c51-ab03-48d4-b092-0ecbc504316c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_CustomerOneMember_4418295c-45b4-40f1-9693-9b300ed96855" xlink:href="aadi-20230630.xsd#aadi_CustomerOneMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_fcc56bb3-05e8-4eda-85c6-0d4e973d0308" xlink:to="loc_aadi_CustomerOneMember_4418295c-45b4-40f1-9693-9b300ed96855" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_CustomerTwoMember_9e1bd5c8-9b29-4ce4-923f-b629a820c38a" xlink:href="aadi-20230630.xsd#aadi_CustomerTwoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_fcc56bb3-05e8-4eda-85c6-0d4e973d0308" xlink:to="loc_aadi_CustomerTwoMember_9e1bd5c8-9b29-4ce4-923f-b629a820c38a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_a49bd932-4b65-449f-87f4-e095295db847" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesTable_1d5d613c-d4e2-4deb-93c2-225f7bbe9c21" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_a49bd932-4b65-449f-87f4-e095295db847" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_a49bd932-4b65-449f-87f4-e095295db847_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_a49bd932-4b65-449f-87f4-e095295db847" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_a49bd932-4b65-449f-87f4-e095295db847_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_bfe6ace9-5c41-4fb5-8bae-c05ca2df8134" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_a49bd932-4b65-449f-87f4-e095295db847" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_bfe6ace9-5c41-4fb5-8bae-c05ca2df8134" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesRevenueNetMember_637b5272-2e76-4365-b7b9-fe1721a02990" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SalesRevenueNetMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_bfe6ace9-5c41-4fb5-8bae-c05ca2df8134" xlink:to="loc_us-gaap_SalesRevenueNetMember_637b5272-2e76-4365-b7b9-fe1721a02990" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableMember_db446564-5474-4a13-afa2-4147deeddf02" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountsReceivableMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_bfe6ace9-5c41-4fb5-8bae-c05ca2df8134" xlink:to="loc_us-gaap_AccountsReceivableMember_db446564-5474-4a13-afa2-4147deeddf02" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_fed80e10-8c44-4348-a134-bc9283f56eec" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesTable_1d5d613c-d4e2-4deb-93c2-225f7bbe9c21" xlink:to="loc_us-gaap_ConcentrationRiskByTypeAxis_fed80e10-8c44-4348-a134-bc9283f56eec" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_fed80e10-8c44-4348-a134-bc9283f56eec_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_fed80e10-8c44-4348-a134-bc9283f56eec" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_fed80e10-8c44-4348-a134-bc9283f56eec_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_7cc3d68a-bc40-4050-b034-38b6e7a6a9aa" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_fed80e10-8c44-4348-a134-bc9283f56eec" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_7cc3d68a-bc40-4050-b034-38b6e7a6a9aa" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CustomerConcentrationRiskMember_d69a291a-79e3-4a4e-8e4a-5a05d815d839" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CustomerConcentrationRiskMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_7cc3d68a-bc40-4050-b034-38b6e7a6a9aa" xlink:to="loc_us-gaap_CustomerConcentrationRiskMember_d69a291a-79e3-4a4e-8e4a-5a05d815d839" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAxis_bb90e015-5c78-485a-9fbd-bb3de67c7fce" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashAndCashEquivalentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesTable_1d5d613c-d4e2-4deb-93c2-225f7bbe9c21" xlink:to="loc_us-gaap_CashAndCashEquivalentsAxis_bb90e015-5c78-485a-9fbd-bb3de67c7fce" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_bb90e015-5c78-485a-9fbd-bb3de67c7fce_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_bb90e015-5c78-485a-9fbd-bb3de67c7fce" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_bb90e015-5c78-485a-9fbd-bb3de67c7fce_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_b51b0a72-3e71-4f8e-9f8d-704b31a451ef" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_bb90e015-5c78-485a-9fbd-bb3de67c7fce" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_b51b0a72-3e71-4f8e-9f8d-704b31a451ef" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_0205d87c-8ac6-4813-9627-f4d05050381b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_b51b0a72-3e71-4f8e-9f8d-704b31a451ef" xlink:to="loc_us-gaap_MoneyMarketFundsMember_0205d87c-8ac6-4813-9627-f4d05050381b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_0457d78b-8849-47ef-9880-d93d475c7886" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesTable_1d5d613c-d4e2-4deb-93c2-225f7bbe9c21" xlink:to="loc_srt_RangeAxis_0457d78b-8849-47ef-9880-d93d475c7886" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_0457d78b-8849-47ef-9880-d93d475c7886_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_0457d78b-8849-47ef-9880-d93d475c7886" xlink:to="loc_srt_RangeMember_0457d78b-8849-47ef-9880-d93d475c7886_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_5711b9b3-1779-4933-a264-f54c16d79539" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_0457d78b-8849-47ef-9880-d93d475c7886" xlink:to="loc_srt_RangeMember_5711b9b3-1779-4933-a264-f54c16d79539" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_3ed912b8-e0f2-4ade-b3aa-3f2b2c3d4f5f" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_5711b9b3-1779-4933-a264-f54c16d79539" xlink:to="loc_srt_MinimumMember_3ed912b8-e0f2-4ade-b3aa-3f2b2c3d4f5f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_26844768-d296-449b-96c5-c4b389183fda" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_5711b9b3-1779-4933-a264-f54c16d79539" xlink:to="loc_srt_MaximumMember_26844768-d296-449b-96c5-c4b389183fda" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_68501670-923d-4551-b5c5-f2e92f2f7632" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ValuationAllowancesAndReservesTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesTable_1d5d613c-d4e2-4deb-93c2-225f7bbe9c21" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_68501670-923d-4551-b5c5-f2e92f2f7632" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesDomain_68501670-923d-4551-b5c5-f2e92f2f7632_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ValuationAllowancesAndReservesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_68501670-923d-4551-b5c5-f2e92f2f7632" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesDomain_68501670-923d-4551-b5c5-f2e92f2f7632_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesDomain_b1c23edc-80e9-45e2-99aa-9a70211bfef3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ValuationAllowancesAndReservesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_68501670-923d-4551-b5c5-f2e92f2f7632" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesDomain_b1c23edc-80e9-45e2-99aa-9a70211bfef3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_ProductSalesAllowanceMember_0984a5ee-98ce-4989-adff-1ad2ca4a6c0d" xlink:href="aadi-20230630.xsd#aadi_ProductSalesAllowanceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesDomain_b1c23edc-80e9-45e2-99aa-9a70211bfef3" xlink:to="loc_aadi_ProductSalesAllowanceMember_0984a5ee-98ce-4989-adff-1ad2ca4a6c0d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_139e348f-9933-4ae2-a4ed-550058a9a977" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesTable_1d5d613c-d4e2-4deb-93c2-225f7bbe9c21" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_139e348f-9933-4ae2-a4ed-550058a9a977" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_139e348f-9933-4ae2-a4ed-550058a9a977_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_139e348f-9933-4ae2-a4ed-550058a9a977" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_139e348f-9933-4ae2-a4ed-550058a9a977_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_c4e70377-0f86-4092-9700-ae7fb9eae71d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_139e348f-9933-4ae2-a4ed-550058a9a977" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_c4e70377-0f86-4092-9700-ae7fb9eae71d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_PrivatePlacementFinancingMember_88ab8bb4-c1d8-436a-aeb6-88b1680c8ec3" xlink:href="aadi-20230630.xsd#aadi_PrivatePlacementFinancingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_c4e70377-0f86-4092-9700-ae7fb9eae71d" xlink:to="loc_aadi_PrivatePlacementFinancingMember_88ab8bb4-c1d8-436a-aeb6-88b1680c8ec3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_c171edd1-fdff-43c4-a9c2-92462f478e42" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesTable_1d5d613c-d4e2-4deb-93c2-225f7bbe9c21" xlink:to="loc_us-gaap_TypeOfArrangementAxis_c171edd1-fdff-43c4-a9c2-92462f478e42" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_c171edd1-fdff-43c4-a9c2-92462f478e42_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_c171edd1-fdff-43c4-a9c2-92462f478e42" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_c171edd1-fdff-43c4-a9c2-92462f478e42_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_1ed85024-2ceb-47fe-a34a-3f40bd06efdf" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_c171edd1-fdff-43c4-a9c2-92462f478e42" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_1ed85024-2ceb-47fe-a34a-3f40bd06efdf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_PurchaseAgreementMember_55f57fd2-e302-4046-b760-c8452ff8f288" xlink:href="aadi-20230630.xsd#aadi_PurchaseAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_1ed85024-2ceb-47fe-a34a-3f40bd06efdf" xlink:to="loc_aadi_PurchaseAgreementMember_55f57fd2-e302-4046-b760-c8452ff8f288" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_c7446c6d-b881-4e98-9562-222c256d7c16" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ClassOfWarrantOrRightAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_aadi_SummaryOfSignificantAccountingPoliciesTable_1d5d613c-d4e2-4deb-93c2-225f7bbe9c21" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_c7446c6d-b881-4e98-9562-222c256d7c16" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_c7446c6d-b881-4e98-9562-222c256d7c16_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_c7446c6d-b881-4e98-9562-222c256d7c16" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_c7446c6d-b881-4e98-9562-222c256d7c16_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_179ea397-a22b-488a-9818-bfd23b6ba83d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_c7446c6d-b881-4e98-9562-222c256d7c16" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_179ea397-a22b-488a-9818-bfd23b6ba83d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_PreFundedWarrantMember_dec1b64f-f68f-4fde-8a71-b5069392eccd" xlink:href="aadi-20230630.xsd#aadi_PreFundedWarrantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_179ea397-a22b-488a-9818-bfd23b6ba83d" xlink:to="loc_aadi_PreFundedWarrantMember_dec1b64f-f68f-4fde-8a71-b5069392eccd" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.aadi.com/role/SummaryofSignificantAccountingPoliciesPropertyandEquipmentDetails" xlink:type="simple" xlink:href="aadi-20230630.xsd#SummaryofSignificantAccountingPoliciesPropertyandEquipmentDetails"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/SummaryofSignificantAccountingPoliciesPropertyandEquipmentDetails" xlink:type="extended" id="ib1898fbaf7804f1583428ecb44bf01ef_SummaryofSignificantAccountingPoliciesPropertyandEquipmentDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_cb62797b-64c9-49d9-9b37-68c168e3f809" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_eada48e8-4014-4f17-a235-bbae66f03349" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_cb62797b-64c9-49d9-9b37-68c168e3f809" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_eada48e8-4014-4f17-a235-bbae66f03349" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_e7d41869-8c99-443a-910d-e7e4e48ec481" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_cb62797b-64c9-49d9-9b37-68c168e3f809" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_e7d41869-8c99-443a-910d-e7e4e48ec481" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_3f71d027-f45a-48ae-bc92-71b14b160bcf" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_cb62797b-64c9-49d9-9b37-68c168e3f809" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_3f71d027-f45a-48ae-bc92-71b14b160bcf" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_dcb60f20-4e4b-4b8e-a91a-7721c61d99a6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_cb62797b-64c9-49d9-9b37-68c168e3f809" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_dcb60f20-4e4b-4b8e-a91a-7721c61d99a6" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_7b9f5da4-0d74-4df0-90dc-74d1eca9adda" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_dcb60f20-4e4b-4b8e-a91a-7721c61d99a6" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_7b9f5da4-0d74-4df0-90dc-74d1eca9adda" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_7b9f5da4-0d74-4df0-90dc-74d1eca9adda_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_7b9f5da4-0d74-4df0-90dc-74d1eca9adda" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_7b9f5da4-0d74-4df0-90dc-74d1eca9adda_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_6bf74283-2a7d-4dbb-b8dc-b7cd74302358" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_7b9f5da4-0d74-4df0-90dc-74d1eca9adda" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_6bf74283-2a7d-4dbb-b8dc-b7cd74302358" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_ComputerEquipmentAndSoftwareMember_1da6c954-6364-41db-b33e-55f5e952e968" xlink:href="aadi-20230630.xsd#aadi_ComputerEquipmentAndSoftwareMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_6bf74283-2a7d-4dbb-b8dc-b7cd74302358" xlink:to="loc_aadi_ComputerEquipmentAndSoftwareMember_1da6c954-6364-41db-b33e-55f5e952e968" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConstructionInProgressMember_01e2d3bf-8c2a-48ec-ade9-3b1c9c0adefd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConstructionInProgressMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_6bf74283-2a7d-4dbb-b8dc-b7cd74302358" xlink:to="loc_us-gaap_ConstructionInProgressMember_01e2d3bf-8c2a-48ec-ade9-3b1c9c0adefd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FurnitureAndFixturesMember_95da43dc-5368-49b9-810c-4af51adafcd3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FurnitureAndFixturesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_6bf74283-2a7d-4dbb-b8dc-b7cd74302358" xlink:to="loc_us-gaap_FurnitureAndFixturesMember_95da43dc-5368-49b9-810c-4af51adafcd3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseholdImprovementsMember_9801e780-fbda-4e07-87f1-021cbc0116d5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LeaseholdImprovementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_6bf74283-2a7d-4dbb-b8dc-b7cd74302358" xlink:to="loc_us-gaap_LeaseholdImprovementsMember_9801e780-fbda-4e07-87f1-021cbc0116d5" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.aadi.com/role/SummaryofSignificantAccountingPoliciesGrosstoNetSalesAdjustmentsDetails" xlink:type="simple" xlink:href="aadi-20230630.xsd#SummaryofSignificantAccountingPoliciesGrosstoNetSalesAdjustmentsDetails"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/SummaryofSignificantAccountingPoliciesGrosstoNetSalesAdjustmentsDetails" xlink:type="extended" id="ic8b24a8c3133489fad7bf53a6a5636ea_SummaryofSignificantAccountingPoliciesGrosstoNetSalesAdjustmentsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_srt_ValuationAndQualifyingAccountsDisclosureLineItems_20978c38-84a8-45e7-b111-807ac3211147" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ValuationAndQualifyingAccountsDisclosureLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_1ac896c6-3a31-42c5-bcb5-60998d95a094" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MovementInValuationAllowancesAndReservesRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureLineItems_20978c38-84a8-45e7-b111-807ac3211147" xlink:to="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_1ac896c6-3a31-42c5-bcb5-60998d95a094" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesBalance_ef330adf-0e97-4381-9524-2b6737a94eba" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ValuationAllowancesAndReservesBalance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_1ac896c6-3a31-42c5-bcb5-60998d95a094" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesBalance_ef330adf-0e97-4381-9524-2b6737a94eba" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesChargedToCostAndExpense_f6363713-dcef-4a22-9753-59e9e35cee1e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ValuationAllowancesAndReservesChargedToCostAndExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_1ac896c6-3a31-42c5-bcb5-60998d95a094" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesChargedToCostAndExpense_f6363713-dcef-4a22-9753-59e9e35cee1e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_SECSchedule1209ValuationAllowancesAndReservesPayments_28c60a2a-90bb-45b0-aa23-29f02af64cf0" xlink:href="aadi-20230630.xsd#aadi_SECSchedule1209ValuationAllowancesAndReservesPayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_1ac896c6-3a31-42c5-bcb5-60998d95a094" xlink:to="loc_aadi_SECSchedule1209ValuationAllowancesAndReservesPayments_28c60a2a-90bb-45b0-aa23-29f02af64cf0" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesBalance_eef9e02b-2f81-4b44-817c-b35d5f304e8f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ValuationAllowancesAndReservesBalance"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ValuationAndQualifyingAccountsDisclosureTable_cbf3207e-58c0-4672-8f0e-3f4c08dcfd74" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ValuationAndQualifyingAccountsDisclosureTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureLineItems_20978c38-84a8-45e7-b111-807ac3211147" xlink:to="loc_srt_ValuationAndQualifyingAccountsDisclosureTable_cbf3207e-58c0-4672-8f0e-3f4c08dcfd74" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_f60c2156-9555-4a8e-8efa-ea365c50fa29" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ValuationAllowancesAndReservesTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureTable_cbf3207e-58c0-4672-8f0e-3f4c08dcfd74" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_f60c2156-9555-4a8e-8efa-ea365c50fa29" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesDomain_f60c2156-9555-4a8e-8efa-ea365c50fa29_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ValuationAllowancesAndReservesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_f60c2156-9555-4a8e-8efa-ea365c50fa29" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesDomain_f60c2156-9555-4a8e-8efa-ea365c50fa29_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesDomain_c91a8bcc-61f3-4ff4-8643-e83343afd31a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ValuationAllowancesAndReservesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_f60c2156-9555-4a8e-8efa-ea365c50fa29" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesDomain_c91a8bcc-61f3-4ff4-8643-e83343afd31a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_ProductSalesAllowanceMember_40fb3114-d13f-4fb5-a686-821eeba18366" xlink:href="aadi-20230630.xsd#aadi_ProductSalesAllowanceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesDomain_c91a8bcc-61f3-4ff4-8643-e83343afd31a" xlink:to="loc_aadi_ProductSalesAllowanceMember_40fb3114-d13f-4fb5-a686-821eeba18366" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.aadi.com/role/SummaryofSignificantAccountingPoliciesScheduleofOutstandingPotentiallyDilutiveSecuritiesExcludedinCalculationofDilutedNetLossperShareDetail" xlink:type="simple" xlink:href="aadi-20230630.xsd#SummaryofSignificantAccountingPoliciesScheduleofOutstandingPotentiallyDilutiveSecuritiesExcludedinCalculationofDilutedNetLossperShareDetail"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/SummaryofSignificantAccountingPoliciesScheduleofOutstandingPotentiallyDilutiveSecuritiesExcludedinCalculationofDilutedNetLossperShareDetail" xlink:type="extended" id="i38e9726daaf9417db48a8866fc98485c_SummaryofSignificantAccountingPoliciesScheduleofOutstandingPotentiallyDilutiveSecuritiesExcludedinCalculationofDilutedNetLossperShareDetail">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_565d362f-6e2a-4db6-ba58-3951fc7c8bde" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_62a1e7a4-9cb3-4274-a27c-0a82896ed37d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_565d362f-6e2a-4db6-ba58-3951fc7c8bde" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_62a1e7a4-9cb3-4274-a27c-0a82896ed37d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_e0706198-6fe9-4cd4-8218-1e7e8543341f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_565d362f-6e2a-4db6-ba58-3951fc7c8bde" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_e0706198-6fe9-4cd4-8218-1e7e8543341f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_cddb9567-fe00-4631-95e9-8d3546b2e66d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_e0706198-6fe9-4cd4-8218-1e7e8543341f" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_cddb9567-fe00-4631-95e9-8d3546b2e66d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_cddb9567-fe00-4631-95e9-8d3546b2e66d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_cddb9567-fe00-4631-95e9-8d3546b2e66d" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_cddb9567-fe00-4631-95e9-8d3546b2e66d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_3ad20dd6-1d89-4730-aabf-aa8cc7937e09" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_cddb9567-fe00-4631-95e9-8d3546b2e66d" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_3ad20dd6-1d89-4730-aabf-aa8cc7937e09" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_2984cbbc-6292-47fc-8f88-ae4437c8fc72" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_3ad20dd6-1d89-4730-aabf-aa8cc7937e09" xlink:to="loc_us-gaap_EmployeeStockOptionMember_2984cbbc-6292-47fc-8f88-ae4437c8fc72" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantMember_c73a15e1-b486-49a4-9c53-737d1588fd45" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_WarrantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_3ad20dd6-1d89-4730-aabf-aa8cc7937e09" xlink:to="loc_us-gaap_WarrantMember_c73a15e1-b486-49a4-9c53-737d1588fd45" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.aadi.com/role/FairValueMeasurementDetails" xlink:type="simple" xlink:href="aadi-20230630.xsd#FairValueMeasurementDetails"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/FairValueMeasurementDetails" xlink:type="extended" id="i1ed05b6e2df74da395c669841057c143_FairValueMeasurementDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_070aae21-0631-403f-acf9-eef2a274c0a2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_24d505ef-cbcc-4203-ad81-3ebc15789ffe" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_070aae21-0631-403f-acf9-eef2a274c0a2" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_24d505ef-cbcc-4203-ad81-3ebc15789ffe" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedGainLossBeforeTax_41310328-4562-41c1-a034-5b5d79a87b69" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedGainLossBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_070aae21-0631-403f-acf9-eef2a274c0a2" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedGainLossBeforeTax_41310328-4562-41c1-a034-5b5d79a87b69" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_56b3ac35-6f8b-4c97-939a-2231f04eccb6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_070aae21-0631-403f-acf9-eef2a274c0a2" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_56b3ac35-6f8b-4c97-939a-2231f04eccb6" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_b64e6d5a-a79c-4cfa-9039-f59faf430c4a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueByMeasurementFrequencyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_56b3ac35-6f8b-4c97-939a-2231f04eccb6" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_b64e6d5a-a79c-4cfa-9039-f59faf430c4a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_b64e6d5a-a79c-4cfa-9039-f59faf430c4a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_b64e6d5a-a79c-4cfa-9039-f59faf430c4a" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_b64e6d5a-a79c-4cfa-9039-f59faf430c4a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_3b1cbc2a-8954-4845-9fd3-2c491c0dae36" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_b64e6d5a-a79c-4cfa-9039-f59faf430c4a" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_3b1cbc2a-8954-4845-9fd3-2c491c0dae36" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_153073dc-d061-45dd-9e18-dc960f8cde6b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueMeasurementsRecurringMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_3b1cbc2a-8954-4845-9fd3-2c491c0dae36" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_153073dc-d061-45dd-9e18-dc960f8cde6b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_af10d45c-7bd5-4502-be24-fcfd1b46abcb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_56b3ac35-6f8b-4c97-939a-2231f04eccb6" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_af10d45c-7bd5-4502-be24-fcfd1b46abcb" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_af10d45c-7bd5-4502-be24-fcfd1b46abcb_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_af10d45c-7bd5-4502-be24-fcfd1b46abcb" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_af10d45c-7bd5-4502-be24-fcfd1b46abcb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3fb3184a-c553-439b-b098-69a46b4d5f9e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_af10d45c-7bd5-4502-be24-fcfd1b46abcb" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3fb3184a-c553-439b-b098-69a46b4d5f9e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_2e4b5c98-81df-4393-8e66-81de8ee3cc17" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3fb3184a-c553-439b-b098-69a46b4d5f9e" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_2e4b5c98-81df-4393-8e66-81de8ee3cc17" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_f1c4185d-dff5-49b2-8c8e-7fe219a67c47" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3fb3184a-c553-439b-b098-69a46b4d5f9e" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_f1c4185d-dff5-49b2-8c8e-7fe219a67c47" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_ddf1d24a-19e7-4285-a9cf-3df803c8c17b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3fb3184a-c553-439b-b098-69a46b4d5f9e" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_ddf1d24a-19e7-4285-a9cf-3df803c8c17b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_4860efd9-8e4f-4fe3-b730-4a13b2f4fd04" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_56b3ac35-6f8b-4c97-939a-2231f04eccb6" xlink:to="loc_us-gaap_FinancialInstrumentAxis_4860efd9-8e4f-4fe3-b730-4a13b2f4fd04" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_4860efd9-8e4f-4fe3-b730-4a13b2f4fd04_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_4860efd9-8e4f-4fe3-b730-4a13b2f4fd04" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_4860efd9-8e4f-4fe3-b730-4a13b2f4fd04_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_8e7611bd-88bc-4d42-95f9-735c056111e0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_4860efd9-8e4f-4fe3-b730-4a13b2f4fd04" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_8e7611bd-88bc-4d42-95f9-735c056111e0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_306137d5-23ac-4f7e-8f8b-c895c7c81329" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_8e7611bd-88bc-4d42-95f9-735c056111e0" xlink:to="loc_us-gaap_MoneyMarketFundsMember_306137d5-23ac-4f7e-8f8b-c895c7c81329" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_7243f598-88e1-4f75-a489-a25c6cf4435c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_8e7611bd-88bc-4d42-95f9-735c056111e0" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_7243f598-88e1-4f75-a489-a25c6cf4435c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperMember_c36d931e-97b6-4de0-b156-b18bafb9f684" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommercialPaperMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_8e7611bd-88bc-4d42-95f9-735c056111e0" xlink:to="loc_us-gaap_CommercialPaperMember_c36d931e-97b6-4de0-b156-b18bafb9f684" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_c7b9f288-174c-49b7-b4ff-8f03a660980b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CorporateDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_8e7611bd-88bc-4d42-95f9-735c056111e0" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_c7b9f288-174c-49b7-b4ff-8f03a660980b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_6eb1d504-959d-4056-9f47-f107c63259a3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_8e7611bd-88bc-4d42-95f9-735c056111e0" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_6eb1d504-959d-4056-9f47-f107c63259a3" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.aadi.com/role/ShortTermInvestmentsandCashEquivalentsDetails" xlink:type="simple" xlink:href="aadi-20230630.xsd#ShortTermInvestmentsandCashEquivalentsDetails"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/ShortTermInvestmentsandCashEquivalentsDetails" xlink:type="extended" id="i40951184d455453d9e98a83b82a3880d_ShortTermInvestmentsandCashEquivalentsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_d8dfb9e6-1629-454b-aa2b-41cb616f07fb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_6cbee6fa-abd2-4c21-8769-800d3ebeddce" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_d8dfb9e6-1629-454b-aa2b-41cb616f07fb" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_6cbee6fa-abd2-4c21-8769-800d3ebeddce" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_7df48851-5616-4447-ba92-0a90ad0b07c5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_d8dfb9e6-1629-454b-aa2b-41cb616f07fb" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_7df48851-5616-4447-ba92-0a90ad0b07c5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_d2dc8a0b-f080-4515-9ef8-4d557e8c7cde" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_d8dfb9e6-1629-454b-aa2b-41cb616f07fb" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_d2dc8a0b-f080-4515-9ef8-4d557e8c7cde" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_230a13ff-0a3f-40f6-9088-53f07f440d11" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_d8dfb9e6-1629-454b-aa2b-41cb616f07fb" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_230a13ff-0a3f-40f6-9088-53f07f440d11" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_616db60c-58ea-4efe-8788-5de155f6d9e5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtSecuritiesAvailableForSaleTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_d8dfb9e6-1629-454b-aa2b-41cb616f07fb" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_616db60c-58ea-4efe-8788-5de155f6d9e5" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_773a11bb-5ccf-452d-ae0e-91d147ccfbbf" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_616db60c-58ea-4efe-8788-5de155f6d9e5" xlink:to="loc_us-gaap_FinancialInstrumentAxis_773a11bb-5ccf-452d-ae0e-91d147ccfbbf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_773a11bb-5ccf-452d-ae0e-91d147ccfbbf_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_773a11bb-5ccf-452d-ae0e-91d147ccfbbf" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_773a11bb-5ccf-452d-ae0e-91d147ccfbbf_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_f2a84f52-2110-45fd-a0c4-5d6d264ed3c1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_773a11bb-5ccf-452d-ae0e-91d147ccfbbf" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_f2a84f52-2110-45fd-a0c4-5d6d264ed3c1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_35565b48-e714-4a26-a1f9-aba2a53ee119" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_f2a84f52-2110-45fd-a0c4-5d6d264ed3c1" xlink:to="loc_us-gaap_MoneyMarketFundsMember_35565b48-e714-4a26-a1f9-aba2a53ee119" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_a12321d9-102e-4ff2-93f6-543b84b6a79d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_f2a84f52-2110-45fd-a0c4-5d6d264ed3c1" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_a12321d9-102e-4ff2-93f6-543b84b6a79d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperMember_ec1e77ef-a8d5-4d9f-a8ef-b733d4e4882c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommercialPaperMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_f2a84f52-2110-45fd-a0c4-5d6d264ed3c1" xlink:to="loc_us-gaap_CommercialPaperMember_ec1e77ef-a8d5-4d9f-a8ef-b733d4e4882c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_ac3e6384-3ccd-4839-be93-dd3b67e07702" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CorporateDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_f2a84f52-2110-45fd-a0c4-5d6d264ed3c1" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_ac3e6384-3ccd-4839-be93-dd3b67e07702" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_3d91934e-0766-4509-a3a6-84f1dcce9f86" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_f2a84f52-2110-45fd-a0c4-5d6d264ed3c1" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_3d91934e-0766-4509-a3a6-84f1dcce9f86" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.aadi.com/role/OperatingLeaseAdditionalInformationDetail" xlink:type="simple" xlink:href="aadi-20230630.xsd#OperatingLeaseAdditionalInformationDetail"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/OperatingLeaseAdditionalInformationDetail" xlink:type="extended" id="ia1dc924665eb4a9591165da6b28b5daf_OperatingLeaseAdditionalInformationDetail">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionLineItems_d01fef09-13e0-4517-94b4-e0e768e68230" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeLeaseDescriptionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseTermOfContract_ccd92653-d63f-4df3-b54c-cdb2a1428c12" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseTermOfContract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_d01fef09-13e0-4517-94b4-e0e768e68230" xlink:to="loc_us-gaap_LesseeOperatingLeaseTermOfContract_ccd92653-d63f-4df3-b54c-cdb2a1428c12" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_OperatingLeaseRentAbatementPeriod_09d03965-5aea-4b2f-a0aa-9ba90e144b09" xlink:href="aadi-20230630.xsd#aadi_OperatingLeaseRentAbatementPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_d01fef09-13e0-4517-94b4-e0e768e68230" xlink:to="loc_aadi_OperatingLeaseRentAbatementPeriod_09d03965-5aea-4b2f-a0aa-9ba90e144b09" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseRenewalTerm_909f23ec-69eb-4da5-bc7a-c2110a625731" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseRenewalTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_d01fef09-13e0-4517-94b4-e0e768e68230" xlink:to="loc_us-gaap_LesseeOperatingLeaseRenewalTerm_909f23ec-69eb-4da5-bc7a-c2110a625731" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_LesseeOperatingLeaseExtendTermForAdditionalPeriod_18286932-97e5-4a68-ac22-b11ad3a42783" xlink:href="aadi-20230630.xsd#aadi_LesseeOperatingLeaseExtendTermForAdditionalPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_d01fef09-13e0-4517-94b4-e0e768e68230" xlink:to="loc_aadi_LesseeOperatingLeaseExtendTermForAdditionalPeriod_18286932-97e5-4a68-ac22-b11ad3a42783" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_LesseeOperatingLeaseRentEscalationPercentage_c686f166-3979-45d4-bc1d-f9d290a9aec4" xlink:href="aadi-20230630.xsd#aadi_LesseeOperatingLeaseRentEscalationPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_d01fef09-13e0-4517-94b4-e0e768e68230" xlink:to="loc_aadi_LesseeOperatingLeaseRentEscalationPercentage_c686f166-3979-45d4-bc1d-f9d290a9aec4" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionTable_d088845c-c9b2-4cdb-a10b-32a904da3a84" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeLeaseDescriptionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_d01fef09-13e0-4517-94b4-e0e768e68230" xlink:to="loc_us-gaap_LesseeLeaseDescriptionTable_d088845c-c9b2-4cdb-a10b-32a904da3a84" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_e3fc6ce5-12c7-40a8-8e0c-6b1ea96836e4" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_d088845c-c9b2-4cdb-a10b-32a904da3a84" xlink:to="loc_srt_StatementGeographicalAxis_e3fc6ce5-12c7-40a8-8e0c-6b1ea96836e4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_e3fc6ce5-12c7-40a8-8e0c-6b1ea96836e4_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_e3fc6ce5-12c7-40a8-8e0c-6b1ea96836e4" xlink:to="loc_srt_SegmentGeographicalDomain_e3fc6ce5-12c7-40a8-8e0c-6b1ea96836e4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_b639aca1-f408-4794-8ff4-e4a271ed893f" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_e3fc6ce5-12c7-40a8-8e0c-6b1ea96836e4" xlink:to="loc_srt_SegmentGeographicalDomain_b639aca1-f408-4794-8ff4-e4a271ed893f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_stpr_CA_e9585a8f-6be1-47ac-acd5-a76c1f4fe0b4" xlink:href="https://xbrl.sec.gov/stpr/2023/stpr-2023.xsd#stpr_CA"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_b639aca1-f408-4794-8ff4-e4a271ed893f" xlink:to="loc_stpr_CA_e9585a8f-6be1-47ac-acd5-a76c1f4fe0b4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_stpr_NJ_ce1f9423-fb4f-4581-9a72-c0369f38400a" xlink:href="https://xbrl.sec.gov/stpr/2023/stpr-2023.xsd#stpr_NJ"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_b639aca1-f408-4794-8ff4-e4a271ed893f" xlink:to="loc_stpr_NJ_ce1f9423-fb4f-4581-9a72-c0369f38400a" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.aadi.com/role/LicenseAgreementsAdditionalInformationDetail" xlink:type="simple" xlink:href="aadi-20230630.xsd#LicenseAgreementsAdditionalInformationDetail"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/LicenseAgreementsAdditionalInformationDetail" xlink:type="extended" id="i0000d078f8df4e26931584118bcbba7b_LicenseAgreementsAdditionalInformationDetail">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CapitalizedContractCostLineItems_d3e3f9ef-e172-4b02-9c0c-a8a93f40e363" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CapitalizedContractCostLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_RoyaltiesWereAccruedOnProductSales_d1c27b6f-b950-4b5b-b35b-0f48edac6c81" xlink:href="aadi-20230630.xsd#aadi_RoyaltiesWereAccruedOnProductSales"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CapitalizedContractCostLineItems_d3e3f9ef-e172-4b02-9c0c-a8a93f40e363" xlink:to="loc_aadi_RoyaltiesWereAccruedOnProductSales_d1c27b6f-b950-4b5b-b35b-0f48edac6c81" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_PaymentsRelatedToMilestone_88e81db4-ad15-4214-ac5e-846d8d241be2" xlink:href="aadi-20230630.xsd#aadi_PaymentsRelatedToMilestone"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CapitalizedContractCostLineItems_d3e3f9ef-e172-4b02-9c0c-a8a93f40e363" xlink:to="loc_aadi_PaymentsRelatedToMilestone_88e81db4-ad15-4214-ac5e-846d8d241be2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_PaymentOfLicenseFees_b362066a-906e-4cfe-a5ce-89b8e46b1dac" xlink:href="aadi-20230630.xsd#aadi_PaymentOfLicenseFees"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CapitalizedContractCostLineItems_d3e3f9ef-e172-4b02-9c0c-a8a93f40e363" xlink:to="loc_aadi_PaymentOfLicenseFees_b362066a-906e-4cfe-a5ce-89b8e46b1dac" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_LicenseFeesIncludingPercentageOfOutstandingPaymentObligation_d8c0ea30-7731-43aa-baaa-c47e498b24ad" xlink:href="aadi-20230630.xsd#aadi_LicenseFeesIncludingPercentageOfOutstandingPaymentObligation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CapitalizedContractCostLineItems_d3e3f9ef-e172-4b02-9c0c-a8a93f40e363" xlink:to="loc_aadi_LicenseFeesIncludingPercentageOfOutstandingPaymentObligation_d8c0ea30-7731-43aa-baaa-c47e498b24ad" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_DueToLicensor_5b05fcc8-3652-41e9-97c6-e6315bb8dc79" xlink:href="aadi-20230630.xsd#aadi_DueToLicensor"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CapitalizedContractCostLineItems_d3e3f9ef-e172-4b02-9c0c-a8a93f40e363" xlink:to="loc_aadi_DueToLicensor_5b05fcc8-3652-41e9-97c6-e6315bb8dc79" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_RelatedPartyTransactionBalloonPaymentInterestRatePerAnnum_4a994024-eb55-4614-b9df-92303bc8397e" xlink:href="aadi-20230630.xsd#aadi_RelatedPartyTransactionBalloonPaymentInterestRatePerAnnum"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CapitalizedContractCostLineItems_d3e3f9ef-e172-4b02-9c0c-a8a93f40e363" xlink:to="loc_aadi_RelatedPartyTransactionBalloonPaymentInterestRatePerAnnum_4a994024-eb55-4614-b9df-92303bc8397e" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromLicenseFeesReceived_36cc1be0-6ae7-4a11-8543-2b409ef22670" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromLicenseFeesReceived"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CapitalizedContractCostLineItems_d3e3f9ef-e172-4b02-9c0c-a8a93f40e363" xlink:to="loc_us-gaap_ProceedsFromLicenseFeesReceived_36cc1be0-6ae7-4a11-8543-2b409ef22670" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_SublicenseFeesPercentage_c6ad0d8b-c9bb-47a7-aee2-d3d5372079df" xlink:href="aadi-20230630.xsd#aadi_SublicenseFeesPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CapitalizedContractCostLineItems_d3e3f9ef-e172-4b02-9c0c-a8a93f40e363" xlink:to="loc_aadi_SublicenseFeesPercentage_c6ad0d8b-c9bb-47a7-aee2-d3d5372079df" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_RightToTerminateLicenseAgreement_bba9ae31-873d-483e-bc12-aa023aa22a66" xlink:href="aadi-20230630.xsd#aadi_RightToTerminateLicenseAgreement"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CapitalizedContractCostLineItems_d3e3f9ef-e172-4b02-9c0c-a8a93f40e363" xlink:to="loc_aadi_RightToTerminateLicenseAgreement_bba9ae31-873d-483e-bc12-aa023aa22a66" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_UpfrontPaymentForLicenseAgreement_7496e3f8-3cb4-454a-8553-8a46e2c00388" xlink:href="aadi-20230630.xsd#aadi_UpfrontPaymentForLicenseAgreement"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CapitalizedContractCostLineItems_d3e3f9ef-e172-4b02-9c0c-a8a93f40e363" xlink:to="loc_aadi_UpfrontPaymentForLicenseAgreement_7496e3f8-3cb4-454a-8553-8a46e2c00388" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_5b6fd75c-d9ae-481c-b572-0cdef3c6e3e0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CapitalizedContractCostLineItems_d3e3f9ef-e172-4b02-9c0c-a8a93f40e363" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_5b6fd75c-d9ae-481c-b572-0cdef3c6e3e0" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_AmountOfCertainDevelopmentRegulatoryAndSalesMilestonesPaymentsEligibleToReceiveUnderLicenseAgreement_f1bde035-057f-4f74-a7db-968ab8cdc070" xlink:href="aadi-20230630.xsd#aadi_AmountOfCertainDevelopmentRegulatoryAndSalesMilestonesPaymentsEligibleToReceiveUnderLicenseAgreement"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CapitalizedContractCostLineItems_d3e3f9ef-e172-4b02-9c0c-a8a93f40e363" xlink:to="loc_aadi_AmountOfCertainDevelopmentRegulatoryAndSalesMilestonesPaymentsEligibleToReceiveUnderLicenseAgreement_f1bde035-057f-4f74-a7db-968ab8cdc070" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CapitalizedContractCostTable_0f22aecb-d4cb-4fad-be59-a07427af824f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CapitalizedContractCostTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_CapitalizedContractCostLineItems_d3e3f9ef-e172-4b02-9c0c-a8a93f40e363" xlink:to="loc_us-gaap_CapitalizedContractCostTable_0f22aecb-d4cb-4fad-be59-a07427af824f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_54651b27-9aae-44a9-b5c1-ea78eb13d209" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_CapitalizedContractCostTable_0f22aecb-d4cb-4fad-be59-a07427af824f" xlink:to="loc_us-gaap_TypeOfArrangementAxis_54651b27-9aae-44a9-b5c1-ea78eb13d209" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_54651b27-9aae-44a9-b5c1-ea78eb13d209_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_54651b27-9aae-44a9-b5c1-ea78eb13d209" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_54651b27-9aae-44a9-b5c1-ea78eb13d209_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_8256691e-5637-49c5-9a9a-426c97f9bb8c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_54651b27-9aae-44a9-b5c1-ea78eb13d209" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_8256691e-5637-49c5-9a9a-426c97f9bb8c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_CelgeneLicenseAgreementMember_45a82335-c99e-4ad3-bb76-21ec6f4a640e" xlink:href="aadi-20230630.xsd#aadi_CelgeneLicenseAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_8256691e-5637-49c5-9a9a-426c97f9bb8c" xlink:to="loc_aadi_CelgeneLicenseAgreementMember_45a82335-c99e-4ad3-bb76-21ec6f4a640e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_8182eb5d-0a1d-4a60-b1d8-490194d6cd7b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_CapitalizedContractCostTable_0f22aecb-d4cb-4fad-be59-a07427af824f" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_8182eb5d-0a1d-4a60-b1d8-490194d6cd7b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_8182eb5d-0a1d-4a60-b1d8-490194d6cd7b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_8182eb5d-0a1d-4a60-b1d8-490194d6cd7b" xlink:to="loc_us-gaap_RelatedPartyDomain_8182eb5d-0a1d-4a60-b1d8-490194d6cd7b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_2cd6bea2-d674-420f-810d-df1e8c800bc1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_8182eb5d-0a1d-4a60-b1d8-490194d6cd7b" xlink:to="loc_us-gaap_RelatedPartyDomain_2cd6bea2-d674-420f-810d-df1e8c800bc1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_CelgeneLicenseAgreementMember_a0e8623d-f8af-4a5d-93f1-4f61dde80dac" xlink:href="aadi-20230630.xsd#aadi_CelgeneLicenseAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_2cd6bea2-d674-420f-810d-df1e8c800bc1" xlink:to="loc_aadi_CelgeneLicenseAgreementMember_a0e8623d-f8af-4a5d-93f1-4f61dde80dac" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_f104ef6b-575d-4e80-994c-bd75fddb5bd9" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_CapitalizedContractCostTable_0f22aecb-d4cb-4fad-be59-a07427af824f" xlink:to="loc_dei_LegalEntityAxis_f104ef6b-575d-4e80-994c-bd75fddb5bd9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_f104ef6b-575d-4e80-994c-bd75fddb5bd9_default" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_f104ef6b-575d-4e80-994c-bd75fddb5bd9" xlink:to="loc_dei_EntityDomain_f104ef6b-575d-4e80-994c-bd75fddb5bd9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_c22c1d1d-75c9-46f2-b35b-4d0b0afcafe7" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_f104ef6b-575d-4e80-994c-bd75fddb5bd9" xlink:to="loc_dei_EntityDomain_c22c1d1d-75c9-46f2-b35b-4d0b0afcafe7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_EOCPharmaHongKongLimitedMember_67c7ad77-1ee3-4a5e-acc9-d5082101f1f3" xlink:href="aadi-20230630.xsd#aadi_EOCPharmaHongKongLimitedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_c22c1d1d-75c9-46f2-b35b-4d0b0afcafe7" xlink:to="loc_aadi_EOCPharmaHongKongLimitedMember_67c7ad77-1ee3-4a5e-acc9-d5082101f1f3" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.aadi.com/role/StockholdersEquityDeficitAdditionalInformationDetail" xlink:type="simple" xlink:href="aadi-20230630.xsd#StockholdersEquityDeficitAdditionalInformationDetail"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/StockholdersEquityDeficitAdditionalInformationDetail" xlink:type="extended" id="i4071bb82cd834ab5b00a4cc886e5444e_StockholdersEquityDeficitAdditionalInformationDetail">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_fee723ad-83ee-4f14-b6d0-c5c11f4deeff" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ClassOfStockLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_4b52cc12-a033-4741-b10a-c413ba201fea" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PreferredStockSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_fee723ad-83ee-4f14-b6d0-c5c11f4deeff" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_4b52cc12-a033-4741-b10a-c413ba201fea" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockParOrStatedValuePerShare_3483bd85-ba5e-4b09-9a89-7349f3dee73c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PreferredStockParOrStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_fee723ad-83ee-4f14-b6d0-c5c11f4deeff" xlink:to="loc_us-gaap_PreferredStockParOrStatedValuePerShare_3483bd85-ba5e-4b09-9a89-7349f3dee73c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesOutstanding_5c5c7311-9ff6-4b57-bdf8-ca715e5e9b2e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PreferredStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_fee723ad-83ee-4f14-b6d0-c5c11f4deeff" xlink:to="loc_us-gaap_PreferredStockSharesOutstanding_5c5c7311-9ff6-4b57-bdf8-ca715e5e9b2e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_9d684d90-8060-47f3-a068-9a778923fd6a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_fee723ad-83ee-4f14-b6d0-c5c11f4deeff" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_9d684d90-8060-47f3-a068-9a778923fd6a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_4c507ee7-c85a-408c-8744-6154444fb5e4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_fee723ad-83ee-4f14-b6d0-c5c11f4deeff" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_4c507ee7-c85a-408c-8744-6154444fb5e4" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_825b4736-db82-463f-8f3d-090fc835c235" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_fee723ad-83ee-4f14-b6d0-c5c11f4deeff" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_825b4736-db82-463f-8f3d-090fc835c235" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_ATMOfferingPrice_2d757158-6210-4450-bd2a-0c5d767a434e" xlink:href="aadi-20230630.xsd#aadi_ATMOfferingPrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_fee723ad-83ee-4f14-b6d0-c5c11f4deeff" xlink:to="loc_aadi_ATMOfferingPrice_2d757158-6210-4450-bd2a-0c5d767a434e" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_ATMOfferingGrossProceedsPaidPercentage_505fbfc3-ca14-4987-8575-026315ce98ad" xlink:href="aadi-20230630.xsd#aadi_ATMOfferingGrossProceedsPaidPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_fee723ad-83ee-4f14-b6d0-c5c11f4deeff" xlink:to="loc_aadi_ATMOfferingGrossProceedsPaidPercentage_505fbfc3-ca14-4987-8575-026315ce98ad" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_12496902-7018-48c0-9bcb-fe96ef30fd2a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_fee723ad-83ee-4f14-b6d0-c5c11f4deeff" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_12496902-7018-48c0-9bcb-fe96ef30fd2a" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_fa97895d-b363-4e7d-aeeb-c35a43770e3e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SaleOfStockPricePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_fee723ad-83ee-4f14-b6d0-c5c11f4deeff" xlink:to="loc_us-gaap_SaleOfStockPricePerShare_fa97895d-b363-4e7d-aeeb-c35a43770e3e" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_84b94106-f48d-4e24-bd37-ee88addafe7d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_fee723ad-83ee-4f14-b6d0-c5c11f4deeff" xlink:to="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_84b94106-f48d-4e24-bd37-ee88addafe7d" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_c0356783-f974-4f7c-a273-ddb536a5cad6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_fee723ad-83ee-4f14-b6d0-c5c11f4deeff" xlink:to="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_c0356783-f974-4f7c-a273-ddb536a5cad6" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfStockIssuanceCosts_ba72c7c7-939f-4d7d-b33f-b79c50af5e80" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsOfStockIssuanceCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_fee723ad-83ee-4f14-b6d0-c5c11f4deeff" xlink:to="loc_us-gaap_PaymentsOfStockIssuanceCosts_ba72c7c7-939f-4d7d-b33f-b79c50af5e80" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_ad37a8c0-30db-4bbd-8c80-12dfd21183cf" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_fee723ad-83ee-4f14-b6d0-c5c11f4deeff" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_ad37a8c0-30db-4bbd-8c80-12dfd21183cf" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsCommonStockCash_3d4d20f9-d069-4e33-ad7c-e60a2567163e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DividendsCommonStockCash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_fee723ad-83ee-4f14-b6d0-c5c11f4deeff" xlink:to="loc_us-gaap_DividendsCommonStockCash_3d4d20f9-d069-4e33-ad7c-e60a2567163e" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_CommonStockNumberOfVotesPerShare_302767b9-e620-41e8-99c2-0c381ea9991f" xlink:href="aadi-20230630.xsd#aadi_CommonStockNumberOfVotesPerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_fee723ad-83ee-4f14-b6d0-c5c11f4deeff" xlink:to="loc_aadi_CommonStockNumberOfVotesPerShare_302767b9-e620-41e8-99c2-0c381ea9991f" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_f4d3e076-6649-48ae-bf51-3c36aacc4281" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfStockByClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_fee723ad-83ee-4f14-b6d0-c5c11f4deeff" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_f4d3e076-6649-48ae-bf51-3c36aacc4281" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_65630093-52b9-45d5-bf70-d1744abe17ee" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_f4d3e076-6649-48ae-bf51-3c36aacc4281" xlink:to="loc_us-gaap_TypeOfArrangementAxis_65630093-52b9-45d5-bf70-d1744abe17ee" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_65630093-52b9-45d5-bf70-d1744abe17ee_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TypeOfArrangementAxis_65630093-52b9-45d5-bf70-d1744abe17ee" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_65630093-52b9-45d5-bf70-d1744abe17ee_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_75fca0bc-21fd-4842-81e4-82f894a126ad" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TypeOfArrangementAxis_65630093-52b9-45d5-bf70-d1744abe17ee" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_75fca0bc-21fd-4842-81e4-82f894a126ad" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_SalesAgreementMember_d8d89707-84ed-4367-939e-4f226710d1c7" xlink:href="aadi-20230630.xsd#aadi_SalesAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_75fca0bc-21fd-4842-81e4-82f894a126ad" xlink:to="loc_aadi_SalesAgreementMember_d8d89707-84ed-4367-939e-4f226710d1c7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_PurchaseAgreementMember_9df72121-d7db-4dc2-9704-eaabd3fa451c" xlink:href="aadi-20230630.xsd#aadi_PurchaseAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_75fca0bc-21fd-4842-81e4-82f894a126ad" xlink:to="loc_aadi_PurchaseAgreementMember_9df72121-d7db-4dc2-9704-eaabd3fa451c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_eb61abbe-5c33-49d6-b30a-8b19a9bdaabb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_f4d3e076-6649-48ae-bf51-3c36aacc4281" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_eb61abbe-5c33-49d6-b30a-8b19a9bdaabb" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_eb61abbe-5c33-49d6-b30a-8b19a9bdaabb_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_eb61abbe-5c33-49d6-b30a-8b19a9bdaabb" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_eb61abbe-5c33-49d6-b30a-8b19a9bdaabb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_495386cc-e1a8-45ce-9855-c4c377a02cd6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_eb61abbe-5c33-49d6-b30a-8b19a9bdaabb" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_495386cc-e1a8-45ce-9855-c4c377a02cd6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_PrivatePlacementFinancingMember_7d3f3b9f-29b9-41ea-9286-cd251e35e998" xlink:href="aadi-20230630.xsd#aadi_PrivatePlacementFinancingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_495386cc-e1a8-45ce-9855-c4c377a02cd6" xlink:to="loc_aadi_PrivatePlacementFinancingMember_7d3f3b9f-29b9-41ea-9286-cd251e35e998" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_266dc797-c06e-48b0-97fb-95e8f8454513" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ClassOfWarrantOrRightAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_f4d3e076-6649-48ae-bf51-3c36aacc4281" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_266dc797-c06e-48b0-97fb-95e8f8454513" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_266dc797-c06e-48b0-97fb-95e8f8454513_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_266dc797-c06e-48b0-97fb-95e8f8454513" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_266dc797-c06e-48b0-97fb-95e8f8454513_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_84019603-a486-434e-8652-619e52099594" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_266dc797-c06e-48b0-97fb-95e8f8454513" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_84019603-a486-434e-8652-619e52099594" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_PreFundedWarrantMember_2439ec40-f6af-4666-85fc-24d591a4190f" xlink:href="aadi-20230630.xsd#aadi_PreFundedWarrantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_84019603-a486-434e-8652-619e52099594" xlink:to="loc_aadi_PreFundedWarrantMember_2439ec40-f6af-4666-85fc-24d591a4190f" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.aadi.com/role/ShareBasedCompensationAdditionalInformationDetail" xlink:type="simple" xlink:href="aadi-20230630.xsd#ShareBasedCompensationAdditionalInformationDetail"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/ShareBasedCompensationAdditionalInformationDetail" xlink:type="extended" id="i4c0dd86f6c49412895bea8f738e042e2_ShareBasedCompensationAdditionalInformationDetail">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3d26ab7d-972d-4771-81ed-17eede6ac2a6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_69559ba9-6834-49d2-9182-4832851a2a31" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockCapitalSharesReservedForFutureIssuance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3d26ab7d-972d-4771-81ed-17eede6ac2a6" xlink:to="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_69559ba9-6834-49d2-9182-4832851a2a31" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_069901b1-19a9-464d-8fd6-f981e5404382" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3d26ab7d-972d-4771-81ed-17eede6ac2a6" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_069901b1-19a9-464d-8fd6-f981e5404382" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_44d72d75-ac74-4076-96ac-fffee0cb9c52" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3d26ab7d-972d-4771-81ed-17eede6ac2a6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_44d72d75-ac74-4076-96ac-fffee0cb9c52" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantedInPeriodAssumedThroughMerger_9e235bc1-2756-407b-a395-8f7f882c5d8a" xlink:href="aadi-20230630.xsd#aadi_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantedInPeriodAssumedThroughMerger"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3d26ab7d-972d-4771-81ed-17eede6ac2a6" xlink:to="loc_aadi_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantedInPeriodAssumedThroughMerger_9e235bc1-2756-407b-a395-8f7f882c5d8a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorizedAnnualPercentage_ae7506ef-3d4f-46e1-b7e7-e3bc913ad7ba" xlink:href="aadi-20230630.xsd#aadi_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorizedAnnualPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3d26ab7d-972d-4771-81ed-17eede6ac2a6" xlink:to="loc_aadi_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorizedAnnualPercentage_ae7506ef-3d4f-46e1-b7e7-e3bc913ad7ba" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_2961df9c-f617-4266-96a8-3a89afd34199" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3d26ab7d-972d-4771-81ed-17eede6ac2a6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_2961df9c-f617-4266-96a8-3a89afd34199" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_e76c33f4-10af-433f-bc87-c61cfd1cb437" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3d26ab7d-972d-4771-81ed-17eede6ac2a6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_e76c33f4-10af-433f-bc87-c61cfd1cb437" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_3e19cd7a-cf9a-4299-9d73-bb96fee62010" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3d26ab7d-972d-4771-81ed-17eede6ac2a6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_3e19cd7a-cf9a-4299-9d73-bb96fee62010" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_75f1f9a2-d66d-4abe-97c5-0b0422eace69" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3d26ab7d-972d-4771-81ed-17eede6ac2a6" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_75f1f9a2-d66d-4abe-97c5-0b0422eace69" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_a54f2c75-b2e2-4bbc-8f09-1234ba25b180" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3d26ab7d-972d-4771-81ed-17eede6ac2a6" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_a54f2c75-b2e2-4bbc-8f09-1234ba25b180" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_068ca651-cdbe-452c-98ed-c3eb3b7289cc" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3d26ab7d-972d-4771-81ed-17eede6ac2a6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_068ca651-cdbe-452c-98ed-c3eb3b7289cc" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightOutstanding_62ea51f6-3f0c-4173-b2cb-745b0a5a330b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ClassOfWarrantOrRightOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3d26ab7d-972d-4771-81ed-17eede6ac2a6" xlink:to="loc_us-gaap_ClassOfWarrantOrRightOutstanding_62ea51f6-3f0c-4173-b2cb-745b0a5a330b" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_decc432a-003b-491e-b6d1-29fba2018186" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3d26ab7d-972d-4771-81ed-17eede6ac2a6" xlink:to="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_decc432a-003b-491e-b6d1-29fba2018186" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityNoteStockSplitConversionRatio1_5044475f-e442-4b33-b3ca-7768a99b7c64" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquityNoteStockSplitConversionRatio1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3d26ab7d-972d-4771-81ed-17eede6ac2a6" xlink:to="loc_us-gaap_StockholdersEquityNoteStockSplitConversionRatio1_5044475f-e442-4b33-b3ca-7768a99b7c64" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_6474ce84-78b2-4730-8803-b4cc80cc49c9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3d26ab7d-972d-4771-81ed-17eede6ac2a6" xlink:to="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_6474ce84-78b2-4730-8803-b4cc80cc49c9" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_NumberOfClassOfWarrantsExercised_05530da0-b6a2-462c-81e7-c7f728befde6" xlink:href="aadi-20230630.xsd#aadi_NumberOfClassOfWarrantsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3d26ab7d-972d-4771-81ed-17eede6ac2a6" xlink:to="loc_aadi_NumberOfClassOfWarrantsExercised_05530da0-b6a2-462c-81e7-c7f728befde6" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_88b44886-26e7-4e42-8034-f38033658ed8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3d26ab7d-972d-4771-81ed-17eede6ac2a6" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_88b44886-26e7-4e42-8034-f38033658ed8" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_26ba8ce5-9b65-4116-adf4-098c8167e246" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PlanNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_88b44886-26e7-4e42-8034-f38033658ed8" xlink:to="loc_us-gaap_PlanNameAxis_26ba8ce5-9b65-4116-adf4-098c8167e246" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_26ba8ce5-9b65-4116-adf4-098c8167e246_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_26ba8ce5-9b65-4116-adf4-098c8167e246" xlink:to="loc_us-gaap_PlanNameDomain_26ba8ce5-9b65-4116-adf4-098c8167e246_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_b65f998d-0a73-495c-b05c-79bfeeb07398" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_26ba8ce5-9b65-4116-adf4-098c8167e246" xlink:to="loc_us-gaap_PlanNameDomain_b65f998d-0a73-495c-b05c-79bfeeb07398" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_PrivateAadiPlanMember_7061a2e1-2673-4560-8237-fb2b6176d76c" xlink:href="aadi-20230630.xsd#aadi_PrivateAadiPlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_b65f998d-0a73-495c-b05c-79bfeeb07398" xlink:to="loc_aadi_PrivateAadiPlanMember_7061a2e1-2673-4560-8237-fb2b6176d76c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_TwoThousandElevenPlanAndTwoThousandSeventeenPlanMember_a2d8b093-f0ab-43f8-891d-3dc7a3476709" xlink:href="aadi-20230630.xsd#aadi_TwoThousandElevenPlanAndTwoThousandSeventeenPlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_b65f998d-0a73-495c-b05c-79bfeeb07398" xlink:to="loc_aadi_TwoThousandElevenPlanAndTwoThousandSeventeenPlanMember_a2d8b093-f0ab-43f8-891d-3dc7a3476709" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_TwoThousandTwentyOneEquityIncentivePlanMember_57c754ea-2cc5-4fd2-83bd-0ded0f4d9fdb" xlink:href="aadi-20230630.xsd#aadi_TwoThousandTwentyOneEquityIncentivePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_b65f998d-0a73-495c-b05c-79bfeeb07398" xlink:to="loc_aadi_TwoThousandTwentyOneEquityIncentivePlanMember_57c754ea-2cc5-4fd2-83bd-0ded0f4d9fdb" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_AerpioTwoThousandElevenEquityIncentivePlanMember_99c16195-dd0b-4a5a-a166-c850d4f6caf7" xlink:href="aadi-20230630.xsd#aadi_AerpioTwoThousandElevenEquityIncentivePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_b65f998d-0a73-495c-b05c-79bfeeb07398" xlink:to="loc_aadi_AerpioTwoThousandElevenEquityIncentivePlanMember_99c16195-dd0b-4a5a-a166-c850d4f6caf7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_AerpioTwoThousandSeventeenStockOptionAndIncentivePlanMember_13b3c149-c088-4f1f-8ba1-6790b431b666" xlink:href="aadi-20230630.xsd#aadi_AerpioTwoThousandSeventeenStockOptionAndIncentivePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_b65f998d-0a73-495c-b05c-79bfeeb07398" xlink:to="loc_aadi_AerpioTwoThousandSeventeenStockOptionAndIncentivePlanMember_13b3c149-c088-4f1f-8ba1-6790b431b666" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_e4e76aa1-476d-48d1-be3b-5e0393869c3c" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_88b44886-26e7-4e42-8034-f38033658ed8" xlink:to="loc_srt_RangeAxis_e4e76aa1-476d-48d1-be3b-5e0393869c3c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_e4e76aa1-476d-48d1-be3b-5e0393869c3c_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_e4e76aa1-476d-48d1-be3b-5e0393869c3c" xlink:to="loc_srt_RangeMember_e4e76aa1-476d-48d1-be3b-5e0393869c3c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_2b115808-9a97-43e4-93d6-920d49c4b4c6" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_e4e76aa1-476d-48d1-be3b-5e0393869c3c" xlink:to="loc_srt_RangeMember_2b115808-9a97-43e4-93d6-920d49c4b4c6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_18f677ea-5b87-494d-b367-623642f5760e" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_2b115808-9a97-43e4-93d6-920d49c4b4c6" xlink:to="loc_srt_MaximumMember_18f677ea-5b87-494d-b367-623642f5760e" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.aadi.com/role/ShareBasedCompensationSummaryofRecognizedCompensationCostRelatedtoEmployeeandNonemployeeStockBasedCompensationActivityDetail" xlink:type="simple" xlink:href="aadi-20230630.xsd#ShareBasedCompensationSummaryofRecognizedCompensationCostRelatedtoEmployeeandNonemployeeStockBasedCompensationActivityDetail"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/ShareBasedCompensationSummaryofRecognizedCompensationCostRelatedtoEmployeeandNonemployeeStockBasedCompensationActivityDetail" xlink:type="extended" id="id2072a591d624ebf9d8d5f8ffaad1805_ShareBasedCompensationSummaryofRecognizedCompensationCostRelatedtoEmployeeandNonemployeeStockBasedCompensationActivityDetail">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_5632d78a-b4b4-427c-99e9-7b92744ab273" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_0ad8fe37-3d92-4d19-9633-d7f310f17ef0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_5632d78a-b4b4-427c-99e9-7b92744ab273" xlink:to="loc_us-gaap_ShareBasedCompensation_0ad8fe37-3d92-4d19-9633-d7f310f17ef0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_23cccc06-3f37-490c-ab82-8eecf0743884" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_5632d78a-b4b4-427c-99e9-7b92744ab273" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_23cccc06-3f37-490c-ab82-8eecf0743884" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_3236741b-7c54-48ff-8d19-9c3f2a0bd90a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_23cccc06-3f37-490c-ab82-8eecf0743884" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_3236741b-7c54-48ff-8d19-9c3f2a0bd90a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_3236741b-7c54-48ff-8d19-9c3f2a0bd90a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_3236741b-7c54-48ff-8d19-9c3f2a0bd90a" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_3236741b-7c54-48ff-8d19-9c3f2a0bd90a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_dc470c4f-37e2-4ca8-a90a-ee5b1b808a03" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_3236741b-7c54-48ff-8d19-9c3f2a0bd90a" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_dc470c4f-37e2-4ca8-a90a-ee5b1b808a03" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpenseMember_eba015fc-1167-4f45-9f92-83c90799e61c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GeneralAndAdministrativeExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_dc470c4f-37e2-4ca8-a90a-ee5b1b808a03" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpenseMember_eba015fc-1167-4f45-9f92-83c90799e61c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_9a9cd184-4552-43ee-a055-96d651a21b8d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ResearchAndDevelopmentExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_dc470c4f-37e2-4ca8-a90a-ee5b1b808a03" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_9a9cd184-4552-43ee-a055-96d651a21b8d" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.aadi.com/role/ShareBasedCompensationStockOptionsValuationAssumptionsDetail" xlink:type="simple" xlink:href="aadi-20230630.xsd#ShareBasedCompensationStockOptionsValuationAssumptionsDetail"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/ShareBasedCompensationStockOptionsValuationAssumptionsDetail" xlink:type="extended" id="i932b172b9b664563873387af77c8066e_ShareBasedCompensationStockOptionsValuationAssumptionsDetail">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_112d8b72-147e-43bc-8c4b-d4158fb316cd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_0ae0244e-c24e-49b6-8eb0-8c7d7dfb18b1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_112d8b72-147e-43bc-8c4b-d4158fb316cd" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_0ae0244e-c24e-49b6-8eb0-8c7d7dfb18b1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_55b890f2-7f04-48fe-8aa6-0ba1957f3a8a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_112d8b72-147e-43bc-8c4b-d4158fb316cd" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_55b890f2-7f04-48fe-8aa6-0ba1957f3a8a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_db4f2229-edc1-4a94-9306-f57e7560a08e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_112d8b72-147e-43bc-8c4b-d4158fb316cd" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_db4f2229-edc1-4a94-9306-f57e7560a08e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_3b5d3a26-a0d8-4c81-b322-dedb48801f40" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_112d8b72-147e-43bc-8c4b-d4158fb316cd" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_3b5d3a26-a0d8-4c81-b322-dedb48801f40" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_3e7305db-5946-4473-b7de-17736d335e07" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_112d8b72-147e-43bc-8c4b-d4158fb316cd" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_3e7305db-5946-4473-b7de-17736d335e07" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_5289764c-7946-4ed4-ae3e-63437ef18471" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_112d8b72-147e-43bc-8c4b-d4158fb316cd" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_5289764c-7946-4ed4-ae3e-63437ef18471" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_6d6d8205-1321-4b42-9df2-b4bb882a06a0" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_5289764c-7946-4ed4-ae3e-63437ef18471" xlink:to="loc_srt_RangeAxis_6d6d8205-1321-4b42-9df2-b4bb882a06a0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_6d6d8205-1321-4b42-9df2-b4bb882a06a0_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_6d6d8205-1321-4b42-9df2-b4bb882a06a0" xlink:to="loc_srt_RangeMember_6d6d8205-1321-4b42-9df2-b4bb882a06a0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_7135ba7b-1f0b-41a3-8d11-e53e4f9092da" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_6d6d8205-1321-4b42-9df2-b4bb882a06a0" xlink:to="loc_srt_RangeMember_7135ba7b-1f0b-41a3-8d11-e53e4f9092da" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_ee32c003-7094-492d-90c9-ecf6f4a496f1" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_7135ba7b-1f0b-41a3-8d11-e53e4f9092da" xlink:to="loc_srt_MinimumMember_ee32c003-7094-492d-90c9-ecf6f4a496f1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_da97d1bf-c63a-4a28-96f9-cdf1715f8ee0" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_7135ba7b-1f0b-41a3-8d11-e53e4f9092da" xlink:to="loc_srt_MaximumMember_da97d1bf-c63a-4a28-96f9-cdf1715f8ee0" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.aadi.com/role/EmployeeStockPurchasePlanAdditionalInformationDetail" xlink:type="simple" xlink:href="aadi-20230630.xsd#EmployeeStockPurchasePlanAdditionalInformationDetail"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/EmployeeStockPurchasePlanAdditionalInformationDetail" xlink:type="extended" id="i47e6fab258544298a765a834d6029573_EmployeeStockPurchasePlanAdditionalInformationDetail">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7b8af5c8-2734-4102-8c3b-3c528391f092" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumEmployeeSubscriptionRate_db262f4c-8904-4b9f-a0b4-2b2bc38482de" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumEmployeeSubscriptionRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7b8af5c8-2734-4102-8c3b-3c528391f092" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumEmployeeSubscriptionRate_db262f4c-8904-4b9f-a0b4-2b2bc38482de" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardOfferingPeriod_457f9c06-364c-4389-9382-cef69cb21dd7" xlink:href="aadi-20230630.xsd#aadi_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardOfferingPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7b8af5c8-2734-4102-8c3b-3c528391f092" xlink:to="loc_aadi_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardOfferingPeriod_457f9c06-364c-4389-9382-cef69cb21dd7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent_152f895e-901d-4a9f-82d8-5ae6faff1bfd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7b8af5c8-2734-4102-8c3b-3c528391f092" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent_152f895e-901d-4a9f-82d8-5ae6faff1bfd" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_f40333a8-44d2-44be-96ec-a1a53c32b427" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockCapitalSharesReservedForFutureIssuance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7b8af5c8-2734-4102-8c3b-3c528391f092" xlink:to="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_f40333a8-44d2-44be-96ec-a1a53c32b427" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_0b856d6a-835f-4e88-94df-b748f36eded1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7b8af5c8-2734-4102-8c3b-3c528391f092" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_0b856d6a-835f-4e88-94df-b748f36eded1" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_NumberOfSharesReservedForIssuanceAnnualIncreasedPercentage_39cda88d-4e44-44da-812e-3a757634b2f8" xlink:href="aadi-20230630.xsd#aadi_NumberOfSharesReservedForIssuanceAnnualIncreasedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7b8af5c8-2734-4102-8c3b-3c528391f092" xlink:to="loc_aadi_NumberOfSharesReservedForIssuanceAnnualIncreasedPercentage_39cda88d-4e44-44da-812e-3a757634b2f8" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_8ded9495-2f0f-4351-a4d3-a550934f3f3f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7b8af5c8-2734-4102-8c3b-3c528391f092" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_8ded9495-2f0f-4351-a4d3-a550934f3f3f" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_ShareBasePaymentArrangementEmployeeStockPurchasePlanLiability_812c4bd3-75fc-4edd-a8be-cd75b4e261f9" xlink:href="aadi-20230630.xsd#aadi_ShareBasePaymentArrangementEmployeeStockPurchasePlanLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7b8af5c8-2734-4102-8c3b-3c528391f092" xlink:to="loc_aadi_ShareBasePaymentArrangementEmployeeStockPurchasePlanLiability_812c4bd3-75fc-4edd-a8be-cd75b4e261f9" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_aadi_ShareBasedCompensationArrangementByShareBasedPaymentAwardStockPlanOfferingPeriod_fa52f929-d0dd-4b64-aad2-3ebed7be8950" xlink:href="aadi-20230630.xsd#aadi_ShareBasedCompensationArrangementByShareBasedPaymentAwardStockPlanOfferingPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7b8af5c8-2734-4102-8c3b-3c528391f092" xlink:to="loc_aadi_ShareBasedCompensationArrangementByShareBasedPaymentAwardStockPlanOfferingPeriod_fa52f929-d0dd-4b64-aad2-3ebed7be8950" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_cd03db1f-38b3-48c6-aba9-a5a28db60ac9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7b8af5c8-2734-4102-8c3b-3c528391f092" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_cd03db1f-38b3-48c6-aba9-a5a28db60ac9" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8276d8dc-4693-41cb-a5b3-bee65dbdce25" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_7b8af5c8-2734-4102-8c3b-3c528391f092" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8276d8dc-4693-41cb-a5b3-bee65dbdce25" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_5f9b26f0-7cdc-4c5c-9139-62a1f04ca99e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8276d8dc-4693-41cb-a5b3-bee65dbdce25" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_5f9b26f0-7cdc-4c5c-9139-62a1f04ca99e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_5f9b26f0-7cdc-4c5c-9139-62a1f04ca99e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_5f9b26f0-7cdc-4c5c-9139-62a1f04ca99e" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_5f9b26f0-7cdc-4c5c-9139-62a1f04ca99e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_7ebce958-2693-48d8-9811-bfe89b3584fd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_5f9b26f0-7cdc-4c5c-9139-62a1f04ca99e" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_7ebce958-2693-48d8-9811-bfe89b3584fd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockMember_31346c74-bd9a-42f6-8021-3202e576da54" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmployeeStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_7ebce958-2693-48d8-9811-bfe89b3584fd" xlink:to="loc_us-gaap_EmployeeStockMember_31346c74-bd9a-42f6-8021-3202e576da54" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_318ef414-5f89-4e06-a251-2482a211354e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8276d8dc-4693-41cb-a5b3-bee65dbdce25" xlink:to="loc_us-gaap_AwardTypeAxis_318ef414-5f89-4e06-a251-2482a211354e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_318ef414-5f89-4e06-a251-2482a211354e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_318ef414-5f89-4e06-a251-2482a211354e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_318ef414-5f89-4e06-a251-2482a211354e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_25039038-349a-45fd-b40b-ae62e7abadfc" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_318ef414-5f89-4e06-a251-2482a211354e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_25039038-349a-45fd-b40b-ae62e7abadfc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockMember_b887398f-bcc1-4fc3-b80f-6ce62ec69b7a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmployeeStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_25039038-349a-45fd-b40b-ae62e7abadfc" xlink:to="loc_us-gaap_EmployeeStockMember_b887398f-bcc1-4fc3-b80f-6ce62ec69b7a" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.aadi.com/role/EmployeeStockPurchasePlanCalculationAssumptionsDetails" xlink:type="simple" xlink:href="aadi-20230630.xsd#EmployeeStockPurchasePlanCalculationAssumptionsDetails"/>
  <link:definitionLink xlink:role="http://www.aadi.com/role/EmployeeStockPurchasePlanCalculationAssumptionsDetails" xlink:type="extended" id="i3ca95e50d4ba49dfa385f3713aa4ac08_EmployeeStockPurchasePlanCalculationAssumptionsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_195d588d-1f98-4c8c-9636-5415bd3dfb64" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExercisePrice_0c844877-4684-4776-a435-9876cf3952c9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_195d588d-1f98-4c8c-9636-5415bd3dfb64" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExercisePrice_0c844877-4684-4776-a435-9876cf3952c9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_34c0e259-d915-4695-9af1-351b00b4aeba" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_195d588d-1f98-4c8c-9636-5415bd3dfb64" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_34c0e259-d915-4695-9af1-351b00b4aeba" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum_4d443ffd-d795-463d-96fe-7a6c450441dc" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_195d588d-1f98-4c8c-9636-5415bd3dfb64" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum_4d443ffd-d795-463d-96fe-7a6c450441dc" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum_f107e3fd-5b9f-4ea3-8aa9-11b704c875ac" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_195d588d-1f98-4c8c-9636-5415bd3dfb64" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum_f107e3fd-5b9f-4ea3-8aa9-11b704c875ac" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_aa5dd46c-941d-4a1f-8d22-a23199cec46d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_195d588d-1f98-4c8c-9636-5415bd3dfb64" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_aa5dd46c-941d-4a1f-8d22-a23199cec46d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum_a04e2c1a-1601-4377-b28e-c3d5929df373" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_195d588d-1f98-4c8c-9636-5415bd3dfb64" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum_a04e2c1a-1601-4377-b28e-c3d5929df373" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum_6cf00f09-65b1-4327-894b-ab43d6a47394" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_195d588d-1f98-4c8c-9636-5415bd3dfb64" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum_6cf00f09-65b1-4327-894b-ab43d6a47394" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_dbb72b71-917e-4f75-8ce7-36a839c3c92e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_195d588d-1f98-4c8c-9636-5415bd3dfb64" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_dbb72b71-917e-4f75-8ce7-36a839c3c92e" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_63d8cd9f-3dfc-4ad2-835d-497411d13f61" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_195d588d-1f98-4c8c-9636-5415bd3dfb64" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_63d8cd9f-3dfc-4ad2-835d-497411d13f61" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_85a8c3ed-b947-477c-9aa7-82ab3009ced6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_195d588d-1f98-4c8c-9636-5415bd3dfb64" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_85a8c3ed-b947-477c-9aa7-82ab3009ced6" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_0268677d-b5b1-4380-8af6-0096aab79321" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_85a8c3ed-b947-477c-9aa7-82ab3009ced6" xlink:to="loc_us-gaap_AwardTypeAxis_0268677d-b5b1-4380-8af6-0096aab79321" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_0268677d-b5b1-4380-8af6-0096aab79321_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_0268677d-b5b1-4380-8af6-0096aab79321" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_0268677d-b5b1-4380-8af6-0096aab79321_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_0e5c5421-40c3-45b7-bd8d-0be3b9c28e29" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_0268677d-b5b1-4380-8af6-0096aab79321" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_0e5c5421-40c3-45b7-bd8d-0be3b9c28e29" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockMember_4fc66b91-b0ca-4ede-8d36-0a48fbe1432c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmployeeStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_0e5c5421-40c3-45b7-bd8d-0be3b9c28e29" xlink:to="loc_us-gaap_EmployeeStockMember_4fc66b91-b0ca-4ede-8d36-0a48fbe1432c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_e251ad06-f590-4ef6-bc86-92715225c11d" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_85a8c3ed-b947-477c-9aa7-82ab3009ced6" xlink:to="loc_srt_RangeAxis_e251ad06-f590-4ef6-bc86-92715225c11d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_e251ad06-f590-4ef6-bc86-92715225c11d_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_e251ad06-f590-4ef6-bc86-92715225c11d" xlink:to="loc_srt_RangeMember_e251ad06-f590-4ef6-bc86-92715225c11d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_5e3e4a3a-552d-43e4-820f-c674de484fcb" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_e251ad06-f590-4ef6-bc86-92715225c11d" xlink:to="loc_srt_RangeMember_5e3e4a3a-552d-43e4-820f-c674de484fcb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_d7ad0b0e-f4fc-44f6-a4ad-6332425ca05f" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_5e3e4a3a-552d-43e4-820f-c674de484fcb" xlink:to="loc_srt_MinimumMember_d7ad0b0e-f4fc-44f6-a4ad-6332425ca05f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_7e3217bf-d51a-4c1b-89fc-a21a48488df8" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_5e3e4a3a-552d-43e4-820f-c674de484fcb" xlink:to="loc_srt_MaximumMember_7e3217bf-d51a-4c1b-89fc-a21a48488df8" xlink:type="arc" order="1"/>
  </link:definitionLink>
</link:linkbase>
